Results 111 to 120 of about 87,298 (292)

The Prophylactic Capacity of Nepeta Menthoides (Ostokhodus) in Prevention of Spinal Motoneuron Injury [PDF]

Journal of Kerman University of Medical Sciences, 2012
Background & Aims: Since apoptotic cell death plays a crucial role in many neurodegenerative diseases, control of apoptosis can be taken into account as a putative neuroprotective strategy.
A.R Azizzadeh delshad, A Forozan
doaj  

Glaucoma: role of neuroprotective agents

, 2017
Glaucoma is an optic neuropathy, considered as the second leading cause of blindness worldwide. Glaucoma is characterized by selective death of retinal ganglion cells (RGC) and a progressive loss of vision.
Singh, Parul, Kaul, Ameeta, Pandey, Achyut N., Sharma, P. D.   +3 more
core  

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Comparative Investigation of the Effects of Adenosine Triphosphate, Melatonin, and Thiamine Pyrophosphate on Amiodarone-Induced Neuropathy and Neuropathic Pain in Male Rats

Biomedicines
Background: Amiodarone is a widely used class III antiarrhythmic agent, but its use can lead to peripheral neuropathy mediated by mitochondrial dysfunction, oxidative stress, and neuroinflammatory injury, while effective preventive options remain limited.
Agah Abdullah Kahramanlar, Habip Burak Ozgodek, Ramazan Ince, Bulent Yavuzer, Ozlem Admis, Ali Sefa Mendil, Bilge Ekinci, Halis Suleyman   +7 more
doaj   +1 more source

Novel 2-Alkylamino-1,4-benzoxazine Derivatives as Potent Neuroprotective Agents: Structure−Activity Relationship Studies

, 2005
International audience2-Alkylamino-substituted-1,4-benzoxazine derivatives, a new class of potential neuroprotective agents, were synthesized and examined for their intrinsic cytotoxicity and their capacity to inhibit oxidative stress-mediated neuronal ...
Lockhart, Brian, Largeron, Martine, Fleury, Maurice-Bernard, Lestage, Pierre, Blattes, Estelle, Gressens, Pierre, Schwendimann, Leslie   +6 more
core   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Potential of naringin, hesperidin and rutin: Phytochemical and biological benefits [PDF]

Scripta Medica
This review provides an overview of the recent biological and phytochemical advancements of the compounds such as naringin, hesperidin and rutin, which are bioactive flavonoids mainly present in citrus fruits with substantial therapeutic potential ...
Kaur Loveleen, Arora Athrv, Gupta Shifali, Kumari Sapna, Garg Madhukar, Chopra Hitesh   +5 more
doaj   +1 more source

Novel 2-Alkylamino-1,4-benzoxazine Derivatives as Potent Neuroprotective Agents:  Structure−Activity Relationship Studies

, 2016
2-Alkylamino-substituted-1,4-benzoxazine derivatives, a new class of potential neuroprotective agents, were synthesized and examined for their intrinsic cytotoxicity and their capacity to inhibit oxidative stress-mediated neuronal degeneration in vitro ...
Estelle Blattes (2692069), Martine Largeron (1662745), Leslie Schwendimann (2692072), Maurice-Bernard Fleury (2391661), Pierre Gressens (104878), Pierre Lestage (305904), Brian Lockhart (229504)   +6 more
core   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source