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Caspase inhibitors as neuroprotective agents
Emerging Drugs, 2001Apoptotic neuronal cell death has been demonstrated to occur in the central nervous system (CNS), following both acute injury and during chronic neurodegenerative conditions. Currently, the majority of experimental evidence for a role of caspases in CNS damage has been established following acute neuronal insults, including ischaemic stroke, traumatic ...
Jeffrey J. Legos +2 more
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GV150526: A Neuroprotective Agent
CNS Drug Reviews, 2000ABSTRACTThromboembolic stroke is a severe, disabling disease characterized by an abrupt reduction of cerebral blood flow, which leads to deprivation of oxygen and nutrients to neuronal tissue, followed by permanent brain damage. Evidence has been accumulated to implicate excitotoxicity in the pathogenesis of ischemic brain injury.
Andrea Terron +4 more
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Neuroprotective effects of anesthetic agents
Journal of Anesthesia, 2005Ischemic neuronal injury is characterized by early death mediated by excitotoxicity and by delayed death caused by apoptosis. Current evidence indicates that volatile agents, barbiturates, and propofol can protect neurons against ischemic injury caused by excitotoxicity.
Piyush M. Patel +2 more
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Leptin as a neuroprotective agent in glaucoma
Medical Hypotheses, 2013Glaucoma is a disease characterized by progressive optic nerve degeneration and is the leading cause of irreversible blindness worldwide. More than 60 million people globally are affected by glaucoma, of which 8 million people suffer from bilateral blindness, making glaucoma the second leading cause of bilateral blindness worldwide.
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Neuroprotective agents in traumatic brain injury [PDF]
Expert Opinion on Investigational Drugs, 2001 The role of neuroprotection in traumatic brain injury (TBI) is reviewed. Basic research and experimental investigations have identified many different compounds with potential neuroprotective effect. However, none of the Phase III trials performed in TBI have been successful in convincingly demonstrating efficacy in the overall population.
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2016
Variations in the physicochemical properties of substituents at the different positions of the coumarin ring were broadly examined under the neurodegenerative disorders, and the results were added to our knowledge for the improvement of compounds that control receptor function.
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Variations in the physicochemical properties of substituents at the different positions of the coumarin ring were broadly examined under the neurodegenerative disorders, and the results were added to our knowledge for the improvement of compounds that control receptor function.
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Introduction: Immunosuppressants as Neuroprotective Agents
2003The discovery that the two most powerful immunosuppressants, cyclosporin A and FK506, are also the most effective neuroprotectants known is profoundly important to neurology. Two drugs that revolutionized the field of organ transplantation as immunosuppressants are beginning to have an even greater impact on medicine in their new role as ...
Eskil Elmér +2 more
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A Review of Agents Patented for their Neuroprotective Properties
Recent Patents on CNS Drug Discovery, 2006The brain continues to remain an area where little corrective surgery can be performed. Recently, the ability to reverse some brain damage and perhaps prevent further damage has moved closer to hospitals and clinics. Several agents demonstrating neuroprotective properties and even neural regeneration have been developed to the extent that they have ...
Margaret A. Brimble, Mark S. Levi
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Risk Assessment Strategies for Neuroprotective Agents
Annals of the New York Academy of Sciences, 1995Neurotoxicity may be defined as any adverse effect on the structure or function of the central and/or peripheral nervous system by a biological, chemical, or physical agent. Neurotoxic effects may be permanent or reversible, produced by neuropharmacological or neurodegenerative properties of a neurotoxicant, or the result of direct or indirect actions ...
William Slikker, David W. Gaylor
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Experimental Neuroprotective Agents
Dimensions Of Critical Care Nursing, 1995Neuroprotective agents are investigational drugs that can potentially suppress the development of secondary brain injury following cerebral traumatic injury. Currently, critical care nurses in research centers are challenged to care for these patients during the clinical trial phase of these drugs.
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