Results 211 to 220 of about 1,639,688 (287)

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Plant extracellular vesicles as emerging neuroprotective agents for central nervous system disorders. [PDF]

J Adv Res
Yu Y, Xu Z, Xu L, Lu D, Tang Y, Mai H.
europepmc   +1 more source

Mesenchymal stem cells as cellular factories for targeted P2X7 blockade after traumatic brain injury

Neuroprotection, EarlyView.
This manuscript presents a novel therapeutic strategy using mesenchymal stem cells (MSCs) engineered as living drug factories to deliver a P2X7‐blocking nanobody for treatment of ischemic stroke. By combining targeted cellular delivery with sustained local immunomodulation, the approach aims to overcome key limitations of systemic biologic ...
Lucia Fadon‐Padilla, Chengyan Chu, Lorissa McDougall, Yajie Liang, Chinmoy Sarkar, Marta Lipinski, Tim Magnus, Miroslaw Janowski, Piotr Walczak   +8 more
wiley   +1 more source

Functional characterization of Shadoo, a PrP-like protein with neuroprotective activity [PDF]

, 2012
Sakthivelu, Vignesh
core   +1 more source

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

Selective COX-2 Inhibitors as Neuroprotective Agents in Traumatic Brain Injury. [PDF]

Biomedicines
Hiskens MI, Schneiders AG, Fenning AS.
europepmc   +1 more source

Burden of ischemic stroke in China from 1990 to 2050: A systematic review and analysis of Global Burden of Disease Study 2021

Neuroprotection, EarlyView.
Based on GBD 2021, the study analyzed the temporal trends of ischemic stroke (IS) burden in China from 1990 to 2021 and forecasted incidence and mortality through 2050. The absolute burden of IS in China will continue to rise by 2050, driven mainly by population aging, with faster age‐standardized incidence rate growth in females than males.
Yijun Zhang, Jinqiao Zhu, Xue Xia, Meng Gao, Yunyi Hao, Anxin Wang   +5 more
wiley   +1 more source

Synthesis, characterization and biological evaluation of aurones as potential neuroprotective agents. [PDF]

Future Med Chem
Ayaz M, Ali Shah SW, Shoaib M, Shah FA, Ahmed F.   +4 more
europepmc   +1 more source

Stem cell–mediated neuroplasticity and psychological recovery in cancer survivors: Mechanisms, evidence, and translational challenges

Precision Medical Sciences, EarlyView.
Cancer therapies can trigger neuroinflammation and disrupted neuroplasticity, contributing to cognitive impairment and psychological distress in survivors. Stem cells (NSCs/MSCs) and their extracellular vesicles may restore neural niches via trophic support, immunomodulation, synaptic remodeling, and vascular repair, but require rigorous safety, dosing,
Xinyi Yang
wiley   +1 more source