Results 251 to 260 of about 129,703 (302)

Development of Pleiotropic TrkB and 5-HT₄ Receptor Ligands as Neuroprotective Agents. [PDF]

Molecules
Antonijevic M, Charou D, Davis A, Curel T, Valcarcel M, Ramos I, Villacé P, Claeysen S, Dallemagne P, Gravanis A, Charalampopoulos I, Rochais C.   +11 more
europepmc   +1 more source

Nuclear Alpha‐Synuclein: Mechanisms and Implications for Synucleinopathies

Movement Disorders, EarlyView.
Abstract Alpha‐synuclein (aSyn), historically studied for its synaptic functions and central role in Lewy body pathology, is emerging as a protein with significant nuclear activities relevant to Parkinson's disease (PD) and related synucleinopathies. Recent advances reveal that aSyn dynamically localizes to neuronal nuclei in both health and disease ...
Tiago Fleming Outeiro, David J. Koss
wiley   +1 more source

Anorexigenic neuropeptides as anti-obesity and neuroprotective agents: exploring the neuroprotective effects of anorexigenic neuropeptides. [PDF]

Biosci Rep
Strnadová V, Pačesová A, Charvát V, Šmotková Z, Železná B, Kuneš J, Maletínská L.   +6 more
europepmc   +1 more source

Glaucomatous optic neuropathy management: the role of neuroprotective agents.

, 2013
Marianne L. Shahsuvaryan
openalex   +1 more source

Curcumin as a neuroprotective agent: mechanisms and therapeutic potential in neurodegenerative diseases, acute brain injuries, and neuroinflammation. A review of the literature [PDF]

Żanna Gawrysz, Zofia Cholewa, Stanisław Derewjanko, Joanna Gaik, Julia Woźniak, Karolina Capar   +5 more
openalex   +1 more source

Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids

Movement Disorders, EarlyView.
Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

A role for lipids as agents to alleviate stroke damage: the neuroprotective effect of 2-hydroxy arachidonic acid

, 2017
Arsenio Fernández‐López, Irene F. Ugidos, Diego Pérez‐Rodríguez   +2 more
openalex   +1 more source

Underlying Mechanisms of the Treatment Efficacy of (R, S)‐Ketamine for Post‐Traumatic Stress Disorder and Depression: A Review

Medicine Advances, EarlyView.
Research shows that (R, S)‐ketamine and its stereoisomers effectively reduce symptoms of post‐traumatic stress disorder (PTSD) and treatment‐resistant depression, with (R)‐ketamine offering similar benefits with fewer side effects. Evidence highlights specific neural circuits and regions, including the dentate gyrus, prefrontal cortex, vCA3, dorsal ...
Thomas Edward Cutting, Richard Evans Hartman   +1 more
wiley   +1 more source

Computational and Experimental Evaluation of Plant-Derived Compounds as Multi-Target Neuroprotective Agents in Neurodegenerative Diseases

Sofia, Dimitrova
openalex   +1 more source