Results 241 to 250 of about 1,639,688 (287)
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Neuroprotection with anaesthetic agents
Current Opinion in Anaesthesiology, 2001The term 'neuroprotection' is used to refer to any prophylactic measure that is initiated during the peri-ischaemic period in order to improve neuronal survival. Cell death after ischaemia has an immediate, necrotic and a delayed, apoptotic origin. The major biochemical mechanisms that are involved in this process include transmembrane ionic fluxes and
Hans, Pol, BONHOMME, Vincent
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Is Lithium a Neuroprotective Agent?
Annals of Clinical Psychiatry, 2015Background Lithium was the first clinically effective mood stabilizer marketed worldwide. However, the medical literature suggests that lithium may have an indication as a neuroprotective agent. Methods This review discusses the pharmacologic activity and potential effectiveness of ...
Thuy M, Vo +3 more
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Neuroprotective agents: Cannabinoids
Clinical Immunology, 2012Chronic inflammation and neurodegeneration are the main pathological traits of multiple sclerosis that coexist in all stages of the disease course, with complex and still nonclarified relationships. Currently licensed medications have efficacy to control aspects related to inflammation, but have been unable to modify pure progression. Experimental work
A J, Sánchez, A, García-Merino
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Minocycline as a Neuroprotective Agent
The Neuroscientist, 2005Several studies have shown that minocycline, a semisynthetic, second-generation tetracycline derivative, is neuroprotective in animal models of central nervous system trauma and several neurodegenerative diseases. Common to all these reports are the beneficial effects of minocycline in reducing neural inflammation and preventing cell death.
David P, Stirling +3 more
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2,5-Diketopiperazines as Neuroprotective Agents
Mini-Reviews in Medicinal Chemistry, 20122,5-diketopiperazines are the simplest cyclic peptides found in nature, commonly biosynthesized from amino acids by different organisms, and represent a promising class of biologically active natural products. Their peculiar heterocyclic structure confers high stability against the proteolysis and constitutes a structural requirement for the active ...
CORNACCHIA, CATIA +5 more
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Physical Medicine and Rehabilitation Clinics of North America, 1999
Although basic research has revealed many mechanisms involved in the repair or elimination of damaged neurons, turning these mechanisms into clinically useful neuroprotective interventions is a slow process. Numerous neurotrophic factors seem to mediate neuronal repair and viability, but because the neurotrophic factors are proteins or polypeptides ...
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Although basic research has revealed many mechanisms involved in the repair or elimination of damaged neurons, turning these mechanisms into clinically useful neuroprotective interventions is a slow process. Numerous neurotrophic factors seem to mediate neuronal repair and viability, but because the neurotrophic factors are proteins or polypeptides ...
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Leptin as a neuroprotective agent
Biochemical and Biophysical Research Communications, 2008Leptin is a hormone produced by adipocytes that regulates satiety (food uptake) and energy homeostasis by activating receptors expressed in neurons of the hypothalamus. Leptin receptors are also found in other brain regions such as the hippocampus and cerebral cortex, and have known roles in regulating neural development and neuroendocrine functions ...
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Caspase inhibitors as neuroprotective agents
Emerging Drugs, 2001Apoptotic neuronal cell death has been demonstrated to occur in the central nervous system (CNS), following both acute injury and during chronic neurodegenerative conditions. Currently, the majority of experimental evidence for a role of caspases in CNS damage has been established following acute neuronal insults, including ischaemic stroke, traumatic ...
J J, Legos, D, Lee, J A, Erhardt
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Neuroprotective effects of anesthetic agents
Journal of Anesthesia, 2005Ischemic neuronal injury is characterized by early death mediated by excitotoxicity and by delayed death caused by apoptosis. Current evidence indicates that volatile agents, barbiturates, and propofol can protect neurons against ischemic injury caused by excitotoxicity.
Masahiko, Kawaguchi +2 more
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