Results 81 to 90 of about 12,549 (250)

DEHYDROEPIANDROSTERONE BIOSYNTHESIS, ROLE AND MECHANISM OF ACTION IN THE DEVELOPING NEURAL TUBE.

Frontiers in Endocrinology, 2012
Dehydroepiandrosterone (DHEA) is synthesized from cholesterol by activity of P450scc and P450c17, enzymes that we previously characterized in the developing nervous system.
mark eGaldo, Christelle S Fiore, Jennifer eGregonis, Nathalie A Compagnone, Nathalie A Compagnone   +4 more
doaj   +1 more source

Pineal Neurosteroids: Biosynthesis and Physiological Functions

Frontiers in Endocrinology, 2020
Similar to the adrenal glands, gonads, and placenta, vertebrate brains also produce various steroids, which are known as “neurosteroids.” Neurosteroids are mainly synthesized in the hippocampus, hypothalamus, and cerebellum; however, it has recently been
Shogo Haraguchi, Kazuyoshi Tsutsui
doaj   +1 more source

Neurosteroids and neurological disorders. [PDF]

Korean J Physiol Pharmacol
Neurosteroids play an important role as endogenous neuromodulators that are locally produced in the central nervous system and rapidly change the excitability of neurons and the activation of microglial cells and astrocytes. Here we review the mechanisms of synthesis, metabolism, and actions of neurosteroids in the central nervous system. Neurosteroids
Park GW, Kim H, Won SH, Kim NH, Choi SR.
europepmc   +3 more sources

The effects of diazepam on the elevated T-maze are dependent on the estrous cycle of rats [PDF]

, 2009
In order to determine the modulation of anxiolytic and panicolytic-like effects of diazepam by the hormonal cycle of female rats, male and female rats - the latter divided per estrous cycle phase (estrus, diestrus, metaestrus and proestrus) - were tested
ANTUNES, Gabriela, GOUVEIA JR, Amauri, MAXIMINO, Caio, MORATO, Silvio   +3 more
core   +1 more source

Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Single‐cell transcriptomics reveals that the human retina expresses a broad repertoire of steroid hormone biosynthesis and estrogen signalling genes. Functional validation in retinal explants shows that local estrogen synthesis is neuroprotective, preventing photoreceptor death and limiting microglial activation. Abstract Steroid hormones, particularly
Antolin Canto, Javier Valero‐Ochando, Rosa López‐Pedrajas, Teresa Olivar, Vicente Hernández‐Rabaza, Inmaculada Almansa, María Miranda   +6 more
wiley   +1 more source

Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential [PDF]

, 2008
Background Factors that regulate intracellular calcium concentration are known to play a critical role in brain function and neural development, including neural plasticity and neurogenesis.
Jun Ming Wang, Roberta Diaz Brinton, EE Baulieu, NA Compagnone, E Plassart-Schiess, KW Gee, KW Gee, D Belelli, D Belelli, D Belelli, MB Herd, AM Hosie, JJ Lambert, E Cherubini, YF Wang, TS Perrot-Sinal, Y Ben-Ari, AN van den Pol, RD Brinton, MC Son, L Zhao, B Berninger, R Gniadecki, AR Means, KP Lu, M van Lookeren Campagne, K Yoshikawa, M Whitaker, R Ashworth, DF Owens, JM Wang, RD Brinton, JM Wang, JM Wang, JM Wang, J Nilsen, TW Wu, PD Henry, D Raeburn, M Son, KW Gee, KW Gee, AC Grobin, QY Liu, G Dayanithi, JJ Lambert, R Rupprecht, LD Sanford, ED Pakarinen, F Impagnatiello, ME Chavez, K Teshima, G Chapouthier, LA Blair, DF Owens, K Obrietan, K Obrietan, K Obrietan, Y Ben-Ari, R Tyzio, Y Ikeda, Y Ikeda, K Obata, E Delpire, KW Sung, AR Brooks-Kayal, KA Behringer, P Montpied, MO Poulter, IE Holopainen, F Didelon, JJ Lambert, M Rahman, R Maitra, D Maric   +74 more
core   +2 more sources

Maternal Milk Allopregnanolone May Buffer Negative Associations Between Maternal Postpartum Psychological Distress and Infant Regulatory Capacity

Developmental Psychobiology, Volume 68, Issue 2, March 2026.
ABSTRACT Maternal psychological distress during pregnancy and the early postpartum period is a risk factor for dysregulated affective and regulatory function in young infants. Animal models suggest that perinatal stress may alter offspring development via allopregnanolone (ALLO) exposure.
Denise M. Werchan, Bradley Susskind, Rebecca Carpio, Brittany R. Howell, Natalie H. Brito, Moriah E. Thomason   +5 more
wiley   +1 more source

Nongenomic effects of neurosteroids

Gynecological Endocrinology, 1998
This review summarizes the current knowledge about the synthesis, the mechanism of action, and the effects of neurosteroids in the central nervous system. Particular attention is paid to the nongenomic actions of neurosteroids, which are discussed in relation to their clinical relevance for physiological and pathological states.
REVELLI, Alberto, TESARIK J., MASSOBRIO, Marco   +2 more
openaire   +3 more sources

Allopregnanolone and Neuroinflammation: a Focus on Multiple Sclerosis

Frontiers in Cellular Neuroscience, 2014
The progesterone derivative, allopregnanolone (ALLO), is one of the most widely studied compounds among neurosteroids. Through interactions with GABA-A receptors expressed by neurons and glial cells, ALLO has been shown to affect diverse aspects of ...
Farshid eNoorbakhsh, Glen B Baker, Christopher ePower   +2 more
doaj   +1 more source

Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons [PDF]

, 2006
Aminoglutethimide is a clinically available drug that suppresses steroid biosynthesis by inhibiting enzymes such as cytochrome P450scc and aromatase. Because several members of neurosteroids regulate glutamate receptors, we investigated the effect of ...
Hisashi Shirakawa, Hiroshi Katsuki, Toshiaki Kume, Shuji Kaneko, Akinori Akaike, ALSHOWAIER, BASTIDA, COIRINI, DI SALLE, FOSTER, FUJIMOTO, GUARNERI, HOLMES, IRWIN, KATSUKI, KIMONIDES, KURATA, MARAGAKIS, MATTSON, MELDRUM, MELLON, MILLER, MILLER, NEDERGAARD, NISHIZAWA, PARK-CHUNG, REDDY, ROBEL, SALHANICK, SHIRAKAWA, SHIRAKAWA, UNGER, VEIGA, WEAVER, WEAVER, WEAVER, WU, YAGHOUBI, ZWAIN   +38 more
core   +2 more sources