Results 131 to 140 of about 270,958 (352)

“Δ133p53α Protects Human Astrocytes from Amyloid-Beta Induced Senescence and Neurotoxicity” [PDF]

, 2021
Kyra Ungerleider, Delphine Lissa, Jessica A. Beck, Izumi Horikawa, Curtis C. Harris   +4 more
openalex   +1 more source

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

Assessing the Consistency of Two Models of Benzene Neurotoxicity Risk Assessment to Create and Validate a Health Risk Screening Guideline Among Fuel Service Workers

International Journal of Occupational Safety and Health
Introduction: This research and development study aimed to (1) evaluate the consistency of two models of benzene neurotoxicity risk assessment (NRA) and (2) create and validate a neurotoxicity risk screening manual among fuel service workers (FSW). Data
Anamai Thetkathuek, Chan Pattama Polyong
doaj   +1 more source

Targeting of the prion protein to the cytosol: mechanisms and consequences

, 2010
Prion diseases are characterized by the conformational transition of the cellular prion protein (PrPC) into an aberrant protein conformer, designated scrapie-prion protein (PrPSc).
Miesbauer, M., Rambold, A., Tatzelt, J., Winkelhofer, K.   +3 more
core  

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

The Incidence of acute Neurotoxicity among some Iraqi colorectal cancer patients treated with oxaliplatin-based chemotherapy

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Oxaliplatin serves as the primary treatment option for colorectal cancer (CRC) at all stages. It induces acute cold-triggered neurotoxicity and chronic cumulative neurotoxicity, leading to potential dose adjustments and influencing patient quality of ...
Rehab AM. Jawad, Bahir Abdul-Razzaq Mshimesh, Qasim S. Al-Mayah, Fawaz Al-Alloosh   +3 more
doaj   +1 more source

Tenofovir disoproxil fumarate induces peripheral neuropathy and alters inflammation and mitochondrial biogenesis in the brains of mice. [PDF]

, 2019
Mounting evidence suggests that antiretroviral therapy (ART) drugs may contribute to the prevalence of HIV-associated neurological dysfunction. The HIV envelope glycoprotein (gp120) is neurotoxic and has been linked to alterations in mitochondrial ...
Achim, Cristian L, Calcutt, Nigel A, Carson, Aliyah, Ellis, Ronald J, Fields, Jerel Adam, Frizzi, Katie, Han, May Madi, Lindsay, Charmaine, Murphy, Anne, Sambhwani, Shrey, Soontornniyomkij, Benchawanna, Swinton, Mary K   +11 more
core  

Deriving Points-of-Departure for Developmental Neurotoxicity New Approach Methodologies

, 2021
Katie Paul Friedman
openalex   +2 more sources

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Author response for "A plausible involvement of plasmalemmal voltage‐dependent anion channel 1 in the neurotoxicity of 15‐deoxy‐Δ ^12,14 ‐prostaglandin J ₂"

, 2020
Hiromi Koma, Y. Yamamoto, Noboru Okamura, Tatsurou Yagami   +3 more
openalex   +1 more source