Results 141 to 150 of about 171,196 (309)
, 2017 Iwao Nakamura, Eiji Ichimura, Rika Goda, Hitomi Hayashi, Hiroko Mashiba, Daichi Nagai, Hirofumi Yokoyama, Takeshi Onda, Akira Masuda Nanomedicine Group, Pharmaceutical Research Laboratories, Nippon Kayaku Co., Ltd., Tokyo, Japan Abstract: In our ...
Ichimura E +8 more
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Proteomics Reveals Mechanisms of Metabolic Dysregulation in Soman Neurotoxicity
Soman, an organophosphorus nerve agent, induces neurotoxicity primarily by inhibiting acetylcholinesterase, triggering a series of pathological events including cholinergic crisis, seizures, calcium overload, oxidative stress, mitochondrial dysfunction ...
Shi, Jingjing +13 more
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Anandamide and noladin ether prevent neurotoxicity of the human amyloid-ß peptide
, 2002 Cannabinoid receptor agonists including anandamide and noladin either have recently been suggested to exhibit neuroprotective properties. The amyloid-β (Aβ) peptide is thought to be responsible for the neurodegenerative changes associated with Alzheimer ...
Milton, N.G.N.
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Advanced Science, EarlyView.Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu +16 more
wiley +1 more source
Cerebral Vascular Toxicity after Developmental Exposure to Arsenic (As) and Lead (Pb) Mixtures
Arsenic (As) and lead (Pb) are environmental pollutants found in common sites linked to similar adverse health effects. This study determined driving factors of neurotoxicity on the developing cerebral vasculature with As and Pb mixture exposures ...
Chongli Yuan +6 more
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Advanced Science, EarlyView.How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Yu Lu +14 more
wiley +1 more source
Advanced Science, EarlyView.In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao +12 more
wiley +1 more source
Neurotoxicity of Metals [electronic resource] /
In this book, international authorities address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of
Aschner, Michael.editor.edthttp://id.loc.gov/vocabulary/relators/edt +2 more
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Advanced Science, EarlyView.Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu +20 more
wiley +1 more source
A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control
Advanced Science, EarlyView.Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias +23 more
wiley +1 more source