Results 71 to 80 of about 189,557 (259)

Acute ketoprofen neurotoxicity in spinal cord of rats [PDF]

Einstein (São Paulo), 2008
Objective: To evaluate possible spinal cord injury in rats followingdifferent doses of intrathecal ketoprofen. Methods: Animalswere divided into four groups of five rats each; 10 μl of anintrathecal solution were injected into the L6-S1 ...
Eric Roger Wroclawski, Maria Tereza Gianotti Galupo, Irimar de Paula Posso, Desiré Carlos Callegari   +3 more
doaj  

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Optimizing the safety of chimeric antigen receptor T cell therapy — current strategies and future direction

Nowotwory
Chimeric antigen receptor T cell (CAR-T) therapy represents a significant advancement in the treatment of hematologicmalignancies, allowing for targeted recognition and elimination of tumor cells. This review summarizes currentknowledge on immunoeffector
Anna E. Szymkiewicz, Filip M. Walczak, Sylwia Trzpiot, Stanisław S. Góźdź, Paweł Steckiewicz, Artur Kowalik   +5 more
doaj   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Central Nervous System Complications in Children Receiving Chemotherapy or Hematopoietic Stem Cell Transplantation

Frontiers in Pediatrics, 2017
Therapy-related neurotoxicity greatly affects possibility of survival and quality of life of pediatric patients treated for cancer. Central nervous system (CNS) involvement is heterogeneous, varying from very mild and transient symptoms to extremely ...
Duccio Maria Cordelli, Riccardo Masetti, Daniele Zama, Francesco Toni, Ilaria Castelli, Emilia Ricci, Emilio Franzoni, Andrea Pession   +7 more
doaj   +1 more source

Integrated Profiling of DEHP-Induced Hippocampal Neurotoxicity in Adult Female Rats Based on Transcriptomic and Neurobiological Analyses

Di-2-ethylhexyl phthalate (DEHP) is a widely used plasticizer with recognized sex-dependent neurotoxicity. However, research on adult neurotoxicity is scarce, especially in females.
Zhang, Xin, Tang, Lei, Ruimin Wang, Xin Zhang, Rui Bian, Gao, Fujia, Wang, Ruimin, Sun, Wuxiang, Fujia Gao, Lei Tang, Li, Jiayu, Wuxiang Sun, Bian, Rui, Jiayu Li, Bai, Jing, Jing Bai   +15 more
core   +1 more source

Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity [PDF]

, 2003
A reduction in microglial activation and subsequent neurotoxicity may prove critical for neuroprotection in neurodegenerative diseases. We examined the expression and functionality of group III metabotropic glutamate (mGlu) receptors on microglia.
Taylor, D.L., Pocock, J.M., Diemel, L.T.
core  

Megalencephaly syndromes: exome pipeline strategies for detecting low-level mosaic mutations [PDF]

, 2014
Two megalencephaly (MEG) syndromes, megalencephaly-capillary malformation (MCAP) and megalencephaly-polymicrogyriapolydactyly?-hydrocephalus(MPPH), have recently been defined on the basis of physical and neuroimaging features.
Cross, Nicholas C. P., Hidalgo-Curtis, Claire, Claire Hidalgo-Curtis (518402), Score, Joannah, Gibson, Jane, Sarah Ennis, Jane Gibson, I Karen Temple, Andrew Collins, Andrew Collins (63814), Nicola Foulds, Paula Aranaz (518400), Foulds, Nicola, Claire Hidalgo-Curtis, I. Karen Temple (518404), Sarah Ennis (435142), David O. Robinson (518403), Temple, I. Karen, William J Tapper, Paula Aranaz, Collins, Andrew, Joannah Score, Nicola Foulds (518399), Joannah Score (518401), Tapper, William J., Robinson, David O., William J. Tapper (518398), Ennis, Sarah, David O Robinson, Aranaz, Paula, Nicholas C P Cross, Jane Gibson (497328), Nicholas C. P. Cross (185184)   +32 more
core   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, EarlyView.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source