Results 141 to 150 of about 57,926 (263)

Proneurogenic and microglial modulatory properties of botulinum neurotoxin in the hippocampus of aging experimental mice. [PDF]

World J Exp Med
Joseph JHM, Babu Deva Irakkam MP, Kandasamy M.   +2 more
europepmc   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Reply to: Is the role of eosinophils in refractory chronic cough truly dismissed? Mepolizumab reduced blood and sputum eosinophils, but not eosinophil-derived neurotoxin. [PDF]

Eur Respir J
Whetstone C, Diab N, Brister D, Kum E, Wahab M, Hassan W, Beaudin S, Obminski C, Wattie J, Wiltshire L, Howie K, Killian K, Holt K, Sehmi R, Smith JA, O'Byrne PM, Satia I, Gauvreau GM.   +17 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Neurofilament light chain as in vitro and clinical biomarker of vincristine‐induced peripheral neuropathy

British Journal of Clinical Pharmacology, EarlyView.
Aims Vincristine‐induced peripheral neuropathy (VIPN) is a common side effect in children and adolescents treated with vincristine. Assessing VIPN, especially in young children, is challenging due to a lack of sensitive tools. This limits our understanding of the nature and risk factors of VIPN. This study aimed to investigate neurofilament light chain
Peter Erik Lotko Pontoppidan, Christian Bach Vase, Christina Mortensen, Liv Andres‐Jensen, Dorte Aalund Olsen, Jonna Skov Madsen, Kjeld Schmiegelow, Rene Mathiasen, Tore Bjerregaard Stage   +8 more
wiley   +1 more source

Intramuscular neural distribution of the soleus for botulinum neurotoxin injection: application to spasticity. [PDF]

Sci Rep
Yi KH, Hu H, Hwang SO, Lee JH, Lee HJ.
europepmc   +1 more source

Ceftriaxone‐induced liver injury: Incidence, phenotypic characterization and predictive factors

British Journal of Clinical Pharmacology, EarlyView.
Introduction Ceftriaxone is a widely used third‐generation cephalosporin in hospitalized patients. Although generally considered safe, it has been associated with hepatobiliary complications and emerging reports of drug‐induced liver injury (DILI). However, data on its true incidence, phenotypic patterns, and predictors remain limited. This study aimed
Mohamed Hatem, Mohannad N. AbuHaweeleh, Humam Emad Rajha, Mhd Osama Rahhal, Ahmad Hamdan, Lina Naseralallah   +5 more
wiley   +1 more source

Distinct pathophysiological mechanisms of <i>Heterometrus laoticus</i> and <i>Lychas mucronatus</i> scorpion venoms on cardiovascular and renal functions. [PDF]

J Venom Anim Toxins Incl Trop Dis
Chaiyabutr N, Chanhome L, Laoungbua P, Vasaruchapong T, Khow O, Reamtong O, Leelahavanichkul A, Sitprija V.   +7 more
europepmc   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, EarlyView.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Cholera Toxin-Mediated Targeting of Botulinum Neurotoxin Activity to Pain-Associated Sensory Neurons. [PDF]

Toxins (Basel)
Corrie E, Bresnahan R, Doran C, Leese C, Balmforth MR, Andreou A, Zhantleuova A, Seward EP, Webb ME, Turnbull WB, Davletov B.   +10 more
europepmc   +1 more source