Results 161 to 170 of about 96,331 (301)

A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis

Animal Models and Experimental Medicine, EarlyView.
A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu, Yafei Yang, Chunxi Liu, Danting Wen, Tingyu Zhao, Ping Xie, Jing Xiao   +6 more
wiley   +1 more source

HUWE1 regulates mitophagy to protect dopaminergic neurons from 6-OHDA- and MPP⁺-induced neurotoxicity. [PDF]

Cell Biol Toxicol
Lee C, Kim DY, Kim SM, Han IO.
europepmc   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

The Patient Voice in Aesthetic Medicine: Findings From a Global Survey of Cosmetic Neurotoxin Patients. [PDF]

Aesthet Surg J Open Forum
Garcia JK, Bennett ME, Lipko-Godlewska S, Keaney TC, Hogue SL, Musumeci M.   +5 more
europepmc   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Observational Evaluation of Muscle Echointensity and EMG Insertional Activity in Poststroke Spasticity. [PDF]

Muscle Nerve
Reebye R, Boissonnault È, Jeon A, Filippetti M, McKernan G, Adenaiye OO, Picelli A, Munin MC.   +7 more
europepmc   +1 more source

Cancer therapy‐induced ototoxicity: Current challenges and emerging management strategies

Animal Models and Experimental Medicine, EarlyView.
This review comprehensively examines the key risk factors for cancer therapy‐induced ototoxicity, including cumulative drug dose, genetic susceptibility, and combined treatment regimens. It highlights current challenges in ototoxicity monitoring, such as insufficient timeliness and limited clinical adoption, and advocates for standardized auditory ...
Yuqi Huang, Baoying Xu, Xinru Chen, Yu Chen, Dehong Yu   +4 more
wiley   +1 more source

Aggregation‐State Dynamics Drive Double Cooperativity Between Antimicrobial Peptides LL‐37 and HNP1

Angewandte Chemie, EarlyView.
The double cooperative effect between LL‐37 and HNP1 arises from dynamic changes in their aggregation state. These LL‐37/HNP1 assemblies reorganize in a target‐dependent manner, suppressing activity toward mammalian cells while enabling potent antibacterial action.
Yuge Hou, Jing Zhang, Koh Takeuchi, Hideo Higuchi, Motoshi Kaya, Rui Li, Jianlu Zheng, Jiali Chen, Go Watanabe, Kaori Sugihara   +9 more
wiley   +2 more sources

Why, When, and How to Treat Dynamic Forehead Lines with Botulinum Toxin Type A. [PDF]

Toxins (Basel)
de Sanctis Pecora C, Kerscher M, Muniz M, Trindade de Almeida A.   +3 more
europepmc   +1 more source

Novel Monoclonal Antibody Detects Small Aβ Oligomers More Sensitively Than Lecanemab in Alzheimer's Disease CSF, Serum and Culture Media

Annals of Neurology, EarlyView.
Objective Aqueously diffusible oligomers of the amyloid β‐protein (oAβ) are neurotoxic and play a role in neuronal dysfunction in Alzheimer's disease (AD). Accurate quantification of oAβ in brains and biofluids could be valuable for understanding and monitoring AD.
Yi Ran Xu, Youqi Tao, Alexandra M. Lish, Shaomin Li, Beth L. Ostaszewski, Amirah K. Anderson, Tracy Young‐Pearse, Trebor L. Lawton, Hyun‐Sik Yang, Dominic M. Walsh, Ting Yang, Dennis J. Selkoe   +11 more
wiley   +1 more source