Results 181 to 190 of about 90,679 (311)

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Internal Jugular Vein Entrapment: An Underrecognized Cause of Facial Pain. [PDF]

Eur J Neurol
Chan K, Gharib M, Karam J, Won S, Cha YH.   +4 more
europepmc   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

The Patient Voice in Aesthetic Medicine: Findings From a Global Survey of Cosmetic Neurotoxin Patients. [PDF]

Aesthet Surg J Open Forum
Garcia JK, Bennett ME, Lipko-Godlewska S, Keaney TC, Hogue SL, Musumeci M.   +5 more
europepmc   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

AI-Based Quantification of Botulinum Neurotoxin-Induced Facial Changes: Wrinkle Reduction, Region-Specific Effects, and Functional Correlates of Facial Muscle Activity. [PDF]

Toxins (Basel)
Güler I, Kraus A, Grieb G, Stelling H.
europepmc   +1 more source

Molecular characterization of a novel botulinum neurotoxin type H gene.

Journal of Infectious Diseases, 2014
N. Dover, J. R. Barash, K. Hill, G. Xie, S. Arnon   +4 more
semanticscholar   +1 more source

Why, When, and How to Treat Dynamic Forehead Lines with Botulinum Toxin Type A. [PDF]

Toxins (Basel)
de Sanctis Pecora C, Kerscher M, Muniz M, Trindade de Almeida A.   +3 more
europepmc   +1 more source

Evolution of the European Medicines Agency clinical guidelines for epilepsy drug development between 2010 and 2025: A comparative analysis by the ILAE Task Force on Regulatory Affairs

Epilepsia, EarlyView.
Abstract Objective The latest European Medicines Agency (EMA) guideline on the clinical investigation of medicines to treat epileptic disorders was adopted by the EMA Committee for Medicinal Products for Human Use in 2025. We compared this guideline with the previous version (2010), highlighting areas where significant revisions were introduced ...
Stéphane Auvin, Alexis Arzimanoglou, Jacqueline French, Kelly G. Knupp, Lieven Lagae, Eugen Trinka, Dennis Dlugos, Emilio Perucca   +7 more
wiley   +1 more source

Neurotoxins [PDF]

, 2011
openaire   +1 more source