Results 171 to 180 of about 43,184 (300)

Post CAR‐T Measurable Residual Disease Monitoring in Mantle Cell Lymphoma Enables Early Detection of Disease Relapse

American Journal of Hematology, EarlyView.
ABSTRACT CD19‐directed chimeric antigen receptor (CAR) T‐cell therapy has transformed outcomes for patients with relapsed or refractory (r/r) mantle cell lymphoma (MCL), yet more than 40% relapse within one year. Early identification of patients at risk for progression could inform post CAR‐T surveillance and consolidation strategies.
Snegha Ananth, Neha Agarwal, Bita Sahaf, Allison Jacob, Lik Wee Lee, Heidi Simmons, Ilan Kirsch, Sushma Bharadwaj, Wen‐kai Weng, Melody Smith, Saurabh Dahiya, David Miklos, Matthew J. Frank   +12 more
wiley   +1 more source

Scorpion Venom Neurotoxins: Molecular Diversity, Mechanisms, and Drug Scaffolds. [PDF]

Toxins (Basel)
Huang Y, Kamau PM, Wang J, Gao M, Li B.
europepmc   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising V_HHs discovered using a consensus antigen. [PDF]

Commun Chem
Damsbo A, Burlet NJ, Fernández-Quintero ML, Benard-Valle M, Overath MD, Guadarrama-Martínez A, Vlamynck A, Bisbo I, Villalobos C, Tulika T, Alagón A, Loeffler JR, Ward AB, Boddum K, Morth JP, Rivera-de-Torre E, Laustsen AH.   +16 more
europepmc   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Discovery of broadly neutralizing V_HHs against short-chain α-neurotoxins using a consensus toxin as an antigen. [PDF]

MAbs
Damsbo A, Benard-Valle M, Jansen T, Burlet NJ, Overath MD, Guadarrama-Martínez A, Boddum K, Alagon A, Rivera-de-Torre E, Laustsen AH.   +9 more
europepmc   +1 more source

Permeabilized cells [PDF]

, 1991
Gratzl, Manfred, Wilschut, J.
core  

A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis

Animal Models and Experimental Medicine, EarlyView.
A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu, Yafei Yang, Chunxi Liu, Danting Wen, Tingyu Zhao, Ping Xie, Jing Xiao   +6 more
wiley   +1 more source

Wound Botulism Complicating a Snake Bite Wound Following Traditional Application of Raw Goat Skin Successfully Treated with Botulinum Antitoxin: A Case Report. [PDF]

Int Med Case Rep J
Rasikh AS, Aram MM, Noory AT, Sarwary A.
europepmc   +1 more source

Neurotoxins [PDF]

, 2011
openaire   +1 more source