Results 181 to 190 of about 7,882 (239)
Clinical Anatomy, EarlyView.ABSTRACT Myofascial pain syndrome (MFPS) causes chronic shoulder pain. Supraspinatus and infraspinatus, rotator cuff muscles innervated by the suprascapular nerve, are commonly affected. Intramuscular botulinum neurotoxin (BoNT) injections near motor points (i.e., visible nerve branch entry sites used as a proxy for motor endplates) are an effective ...
Dave Osinachukwu Duru +5 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt +3 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi +6 more
wiley +1 more source
Opsoclonus in Pediatric Patients: Differential Diagnosis and a Practical Approach to Evaluation
Annals of the Child Neurology Society, EarlyView.ABSTRACT Opsoclonus is an ocular dyskinesia characterized by involuntary, arrhythmic, multidirectional saccades. In pediatrics, opsoclonus is most commonly attributed to the rare neuroinflammatory disorder opsoclonus‐myoclonus‐ataxia syndrome (OMAS), typically considered a paraneoplastic syndrome associated with neural crest tumors. However, opsoclonus
Aubrey C. Reed +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor +12 more
wiley +1 more source
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Toxicon, 2013
α-Neurotoxins have been isolated from hydrophid, elapid and, more recently, colubrid snake venoms. Also referred to as postsynaptic neurotoxins or 'curare mimetic' neurotoxins, they play an important role in the capture and/or killing of prey by binding to the nicotinic acetylcholine receptor on the skeletal muscle disrupting neurotransmission.
Wayne Hodgson, Geoffrey Isbister
exaly +3 more sources
α-Neurotoxins have been isolated from hydrophid, elapid and, more recently, colubrid snake venoms. Also referred to as postsynaptic neurotoxins or 'curare mimetic' neurotoxins, they play an important role in the capture and/or killing of prey by binding to the nicotinic acetylcholine receptor on the skeletal muscle disrupting neurotransmission.
Wayne Hodgson, Geoffrey Isbister
exaly +3 more sources
Facial Plastic Surgery, 2019
AbstractBotulinum toxin is integral to the practice of facial plastic surgery. Since it was approved by the U.S. Food and Drug Administration for the temporary improvement of glabellar rhytids in 2002, botulinum toxin has achieved a growing number of off-label clinical applications. These include the management of facial rhytids, brow ptosis, excessive
Adrian A. Ong, David A. Sherris
openaire +2 more sources
AbstractBotulinum toxin is integral to the practice of facial plastic surgery. Since it was approved by the U.S. Food and Drug Administration for the temporary improvement of glabellar rhytids in 2002, botulinum toxin has achieved a growing number of off-label clinical applications. These include the management of facial rhytids, brow ptosis, excessive
Adrian A. Ong, David A. Sherris
openaire +2 more sources
2022
The cycads are a group of relict Mesozoic plants of which 10 genera now exist in the mainly tropical to warm temperate regions of the world. An additional toxicity which affects cattle after weeks of consumption of cycad leaves is a posterior ataxia known locally as “zamia staggers”. A toxin responsible for this condition has not so far been discovered.
Seawright, Alan A. +3 more
openaire +2 more sources
The cycads are a group of relict Mesozoic plants of which 10 genera now exist in the mainly tropical to warm temperate regions of the world. An additional toxicity which affects cattle after weeks of consumption of cycad leaves is a posterior ataxia known locally as “zamia staggers”. A toxin responsible for this condition has not so far been discovered.
Seawright, Alan A. +3 more
openaire +2 more sources
Clinical Toxicology, 1981
Nonprotein neurotoxins are continuing to play a major role as molecular probes in studying nervous processes. They also have clinical importance as some of them, such as saxitoxin and its analogues, are the source of public health problems, or have potential use in therapy.
D J, Bower +3 more
openaire +2 more sources
Nonprotein neurotoxins are continuing to play a major role as molecular probes in studying nervous processes. They also have clinical importance as some of them, such as saxitoxin and its analogues, are the source of public health problems, or have potential use in therapy.
D J, Bower +3 more
openaire +2 more sources