Results 181 to 190 of about 26,374 (300)

From Gut to Systemic Circulation: Molecular Strategies of Botulinum Neurotoxin Complexes. [PDF]

Toxins (Basel)
Mondy J, Lemichez E.
europepmc   +1 more source

TIPS in Older Adults: Reserve-Based Risk Stratification and Practical Approach. [PDF]

J Clin Med
He Y, Li Y, Gao L, Wang X.
europepmc   +1 more source

Ranking of antiseizure medications in a panel of focal seizure models predicts their comparative efficacy in clinical add‐on trials in drug‐resistant focal epilepsy

Epilepsia, EarlyView.
Abstract Objective Most antiseizure medications (ASMs) have been discovered by testing in animal models, which are generally thought to predict antiseizure activity in patients. However, it is not known whether any of these models (or a combination of models) can predict whether a novel ASM exhibits higher clinical efficacy in focal drug‐resistant ...
Wolfgang Löscher, Pavel Klein
wiley   +1 more source

Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall, Abbas I. Hussain, Michelle Cho, Patrick A. Forcelli   +3 more
wiley   +1 more source

Distinct pathophysiological mechanisms of <i>Heterometrus laoticus</i> and <i>Lychas mucronatus</i> scorpion venoms on cardiovascular and renal functions. [PDF]

J Venom Anim Toxins Incl Trop Dis
Chaiyabutr N, Chanhome L, Laoungbua P, Vasaruchapong T, Khow O, Reamtong O, Leelahavanichkul A, Sitprija V.   +7 more
europepmc   +1 more source

Glymphatic dysfunction couples with cortical excitation–inhibition imbalance in epilepsy: Evidence from Rasmussen encephalitis

Epilepsia, EarlyView.
Cong Fu et al. demonstrate that glymphatic system dysfunction is linked to enhanced inhibitory cortical activity using diffusion MRI and EEG. These findings highlight a mechanistic link between perivascular fluid dynamics and neuronal activity, suggesting a role for glymphatic function in maintaining cortical stability in epilepsy.
Cong Fu, Yujiao Yang, Pan Gong, Kun Lv, Yilin Liu, Chongyang Tang, Xiongfei Wang, Lixin Cai, Qingzhu Liu, Yuwu Jiang, Taoyun Ji, Guoming Luan   +11 more
wiley   +1 more source

Immunogenicity of two representative American consensus scorpion neurotoxins from the genera Tityus and Centruroides. [PDF]

PLoS Negl Trop Dis
Cardoso-Arenas S, Mejia-Sanchez MA, Miranda-Blancas R, Clement H, Corrales-García L, Arenas I, Espino-Solís GP, Acosta H, Salazar MH, Corzo G.   +9 more
europepmc   +1 more source

Modeling temporal lobe epilepsy with hippocampal sclerosis in rats using the selective neurotoxin stable substance P‐saporin

Epilepsia, EarlyView.
On day 0 adult male and female rats were injected with Stable Substance P‐Saporin (SSP‐SAP) at 4 unilateral sites along the longitudinal axis of the dentate gyrus. Rats exhibited spontaneous electrographic and behavioral reactive seizures between days 4‐6. There was a progressive loss of CA1 and CA3 neurons and a progressive increase in astrocytes over
Srijal Gupta, Mitchell T. Kesler, Morris H. Scantlebury, Robert S. Sloviter, G. Campbell Teskey   +4 more
wiley   +1 more source

Scorpion Venom Neurotoxins: Molecular Diversity, Mechanisms, and Drug Scaffolds. [PDF]

Toxins (Basel)
Huang Y, Kamau PM, Wang J, Gao M, Li B.
europepmc   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source