Results 271 to 280 of about 77,752 (388)

Neuroprotective effects of melanins and melanin derivatives from Calvatia Craniiformis and Xylaria plebeja against Parkinsonian toxins. [PDF]

Sci Rep
Nguyen DT, Nguyen Vo LP, Mangelings D, Van Eeckhaut A, Vander Heyden Y, Tran HTM.   +5 more
europepmc   +1 more source

EPR kinetic studies of superoxide radicals generated during the autoxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium, a bioactivated intermediate of parkinsonian-inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

, 1992
Lun‐Yi Zang, H. P. Misra
openalex   +1 more source

Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation

ChemMedChem, EarlyView.
Ubiquitin‐specific protease 7 (USP‐7) is a novel target for anticancer therapy. To further extend the structure–activity relationships of the previously USP‐7 inhibitor STIRUR‐41, a library of 5‐aminopyrazoles is reported. 1d shows a potency comparable to lead compound STIRUR‐41 and promising in silico and in vitro pharmacokinetic properties ...
Matteo Lusardi, Elva Morretta, Andrea Spallarossa, Maria Chiara Monti, Camillo Rosano, Erika Iervasi, Marco Ponassi, Matteo Mori, Fiorella Meneghetti, Chiara Brullo   +9 more
wiley   +1 more source

Molecular Insights into the Low Complexity Secreted Venom of Calliactis polypus. [PDF]

Genome Biol Evol
Smith HL, Broszczak DA, Bryan SE, Norton RS, Prentis PJ.   +4 more
europepmc   +1 more source

Genetic diversity within the botulinum neurotoxin-producing bacteria and their neurotoxins.

Toxicon, 2015
K. Hill, Gary Xie, Brian T. Foley, Theresa J. Smith   +3 more
semanticscholar   +1 more source

Manganese Neurotoxicity and Familial Disorders of Manganese Transport

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley   +1 more source

Purification and Molecular Characterization of a Mammalian Neurotoxin as a Pharmaceutical Tool from the Venom of Iranian Scorpion <i>Androctonus crassicauda</i>. [PDF]

J Arthropod Borne Dis
Rabiei H, Zare-Mirakabadi A, Mohtat B, Mirza B.   +3 more
europepmc   +1 more source

Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions

Cancer Nexus, EarlyView.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley   +1 more source

How to Overcome a Snail? Identification of Putative Neurotoxins of Snail-Feeding Firefly Larvae (Coleoptera: Lampyridae, <i>Lampyris noctiluca</i>). [PDF]

Toxins (Basel)
Krämer J, Hölker P, Predel R.
europepmc   +1 more source