Results 301 to 310 of about 77,752 (388)

Does the Diffusion Profile Differ Between Botulinum Toxin Type a Formulations? Implications for the Management of Post-Stroke Spasticity. [PDF]

Toxins (Basel)
Picelli A, Tamburin S, Di Censo R, Smania N, Filippetti M.   +4 more
europepmc   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

Inherent fast inactivation particle of Nav channels as a new binding site for a neurotoxin. [PDF]

EMBO J
Zhou X, Chen H, Peng S, Si Y, Wang G, Yang L, Zhou Q, Lu M, Xie Q, He X, Wu M, Xiao X, Luo X, Feng X, Wang W, Luo S, Li Y, Qin J, Chen M, Zhang Q, Hu W, Liang S, Hou T, Liu Z.   +23 more
europepmc   +1 more source

Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials

Exploration, EarlyView.
Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment, has been emerging as a key participant and driving factor in cancer. This article reviews the latest progress in this field, including the microbial community within tumors and its pro‐cancer mechanisms, as well as the anti‐tumor strategies targeting intra‐tumoral ...
Yanan Niu, Junya Feng, Jie Ma, Tixian Xiao, Wei Yuan   +4 more
wiley   +1 more source

Case Report: Palmaris Brevis Syndrome Resulting From Acute Wrist Hyperextension. [PDF]

Plast Surg (Oakv)
McGrath AEG, Robb JL.
europepmc   +1 more source

Enhanced Blood‐Brain Barrier Penetrability of BACE1 SiRNA‐Loaded Prussian Blue Nanocomplexes for Alzheimer's Disease Synergy Therapy

Exploration, EarlyView.
BACE1 interfering RNA, metallothionein and ruthenium complexes ([Ru(bpy)2dppz]2+) were all loaded in prussian blue nanoparticles (PRM‐siRNA). PRM‐siRNA under near‐infrared light irradiation showed good photothermal effect and triggered instantaneous opening of blood‐brain barrier for enhanced drug delivery.
Xiaoyuan Ding, Yanyu Hu, Xiaotong Feng, Zekun Wang, Qile Song, Chunxue Dai, Bangjia Yang, Xiaoyan Fu, Dongdong Sun, Cundong Fan   +9 more
wiley   +1 more source

A High-Throughput Biosensing Approach for Rapid Screening of Compounds Targeting the hNav1.1 Channel: Marine Toxins as a Case Study. [PDF]

Mar Drugs
Shen H, Cui Y, Liang S, Zhou S, Li Y, Wu Y, Song J.   +6 more
europepmc   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Expression of Recombinant Clostridial Neurotoxin by C. tetani. [PDF]

Microorganisms
Gregg BM, Gupta S, Tepp WH, Pellett S.
europepmc   +1 more source

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source