Results 1 to 10 of about 10,948 (148)
Presynaptic Autophagy and the Connection With Neurotransmission
Frontiers in Cell and Developmental Biology, 2021 Autophagy is an evolutionary conserved catabolic pathway essential for the maintenance of cellular homeostasis. Defective proteins and organelles are engulfed by autophagosomal membranes which fuse with lysosomes for cargo degradation.
Marianna Decet +3 more
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Frontiers in Cellular Neuroscience, 2021 Neurotransmitter dynamics within neuronal synapses can be controlled by astrocytes and reflect key contributors to neuronal activity. In particular, Glutamate (Glu) released by activated neurons is predominantly removed from the synaptic space by ...
Bronac Flanagan +5 more
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Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis
eLife, 2020 Calcium (Ca2+)-evoked release of neurotransmitters from synaptic vesicles requires mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion following Ca2+-influx. The principal components involved in these processes are
Sathish Ramakrishnan +4 more
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Frontiers in Neuroscience, 2021 Selenium (Se) and its compounds have been reported to have great potential in the prevention and treatment of Alzheimer’s disease (AD). However, little is known about the functional mechanism of Se in these processes, limiting its further clinical ...
Zhong-Hao Zhang +4 more
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Food-derived Acetylcholinesterase Inhibitors as Potential Agents against Alzheimer’s Disease
eFood, 2021 Acetylcholinesterase (AChE) is a critical enzyme involved in nerve functions and signal transmission within the brain. However, during aging, excessive AChE activity often leads to rapid and progressive depletion of acetylcholine (ACh), the major ...
Rotimi E. Aluko
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Cell Reports, 2013 Expression of the human Parkinson-disease-associated protein α-synuclein in all Drosophila neurons induces progressive locomotor deficits. Here, we identify a group of 15 dopaminergic neurons per hemisphere in the anterior medial region of the brain ...
Thomas Riemensperger +8 more
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Phosphatidylserine, inflammation, and central nervous system diseases
Frontiers in Aging Neuroscience, 2022 Phosphatidylserine (PS) is an anionic phospholipid in the eukaryotic membrane and is abundant in the brain. Accumulated studies have revealed that PS is involved in the multiple functions of the brain, such as activation of membrane signaling pathways ...
Xiaohua Ma +7 more
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Targeted Sensors for Glutamatergic Neurotransmission [PDF]
Biophysical Journal, 2021 AbstractOptical report of neurotransmitter release allows visualization of excitatory synaptic transmission. Sensitive genetically-encoded glutamate reporters operating with a range of affinities and emission wavelengths are available. However, without targeting to synapses, the specificity of the fluorescent signal is uncertain, compared to sensors ...
Christian Rosenmund +6 more
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Phosphatidic acid and neurotransmission [PDF]
Advances in Biological Regulation, 2017 Lipids play a vital role in the health and functioning of neurons and interest in the physiological role of neuronal lipids is certainly increasing. One neuronal function in which neuronal lipids appears to play key roles in neurotransmission. Our understanding of the role of lipids in the synaptic vesicle cycle and neurotransmitter release is becoming
Casey N. Barber, Daniel M. Raben
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