Results 1 to 10 of about 229,968 (342)

Fundamental Neurochemistry Review: GABAA receptor neurotransmission and epilepsy: Principles, disease mechanisms and pharmacotherapy

Journal of Neurochemistry, 2023
Epilepsy is a common neurological disorder associated with alterations of excitation‐inhibition balance within brain neuronal networks. GABAA receptor neurotransmission is the most prevalent form of inhibitory neurotransmission and is strongly implicated
Alexander Bryson, C. Reid, S. Petrou
semanticscholar   +1 more source

The Role of Serotonin Neurotransmission in Gastrointestinal Tract and Pharmacotherapy

Molecules, 2022
5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in both the central nervous system and peripheral structures, acting also as a hormone in platelets.
Tomasz Guzel, D. Mirowska-Guzel
semanticscholar   +1 more source

Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain

Frontiers in Molecular Neuroscience, 2022
Opioids mediate their effects via opioid receptors: mu, delta, and kappa. At the neuronal level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter release and postsynaptically hyperpolarizing neurons.
Kaitlin C. Reeves, Nikhil P. Shah, B. Muñoz, Brady K. Atwood   +3 more
semanticscholar   +1 more source

Complex opioid-driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward, and addiction. [PDF]

Elife
Chittajallu R, Vlachos A, Caccavano AP, Yuan X, Hunt S, Abebe D, London E, Pelkey KA, McBain CJ.   +8 more
europepmc   +3 more sources

Autism Spectrum Disorder: Focus on Glutamatergic Neurotransmission

International Journal of Molecular Sciences, 2022
Disturbances in the glutamatergic system have been increasingly documented in several neuropsychiatric disorders, including autism spectrum disorder (ASD).
M. Montanari, G. Martella, P. Bonsi, Maria Meringolo   +3 more
semanticscholar   +1 more source

Memory Enhancement with Kynurenic Acid and Its Mechanisms in Neurotransmission

Biomedicines, 2022
Kynurenic acid (KYNA) is an endogenous tryptophan (Trp) metabolite known to possess neuroprotective property. KYNA plays critical roles in nociception, neurodegeneration, and neuroinflammation.
Diána Martos, Bernadett Tuka, Masaru Tanaka, L. Vécsei, G. Telegdy   +4 more
semanticscholar   +1 more source

Adenosine Receptors in Neuropsychiatric Disorders: Fine Regulators of Neurotransmission and Potential Therapeutic Targets

International Journal of Molecular Sciences, 2022
Adenosine exerts an important role in the modulation of central nervous system (CNS) activity. Through the interaction with four G-protein coupled receptor (GPCR) subtypes, adenosine subtly regulates neurotransmission, interfering with the dopaminergic ...
Silvia Pasquini, Chiara Contri, S. Merighi, S. Gessi, P. Borea, K. Varani, F. Vincenzi   +6 more
semanticscholar   +1 more source

Role of the UNC13 family in human diseases: A literature review

AIMS Neuroscience, 2023
This literature review explores the pivotal roles of the Uncoordinated-13 (UNC13) protein family, encompassing UNC13A, UNC13B, UNC13C, and UNC13D, in the pathogenesis of various human diseases.
Ubaid Ansari, Vincent Chen , Romteen Sedighi, Burhaan Syed, Zohaer Muttalib, Khadija Ansari, Fatima Ansari, Denise Nadora, Daniel Razick , Forshing Lui   +9 more
doaj   +1 more source

Dynamic control of the dopamine transporter in neurotransmission and homeostasis

npj Parkinson's Disease, 2021
The dopamine transporter (DAT) transports extracellular dopamine into the intracellular space contributing to the regulation of dopamine neurotransmission.
Mengfei Bu, M. Farrer, Habibeh Khoshbouei   +2 more
semanticscholar   +1 more source

Roles of Selenoproteins in Brain Function and the Potential Mechanism of Selenium in Alzheimer’s Disease

Frontiers in Neuroscience, 2021
Selenium (Se) and its compounds have been reported to have great potential in the prevention and treatment of Alzheimer’s disease (AD). However, little is known about the functional mechanism of Se in these processes, limiting its further clinical ...
Zhong-Hao Zhang, Zhong-Hao Zhang, Guo-Li Song, Guo-Li Song, Guo-Li Song   +4 more
doaj   +1 more source