Results 41 to 50 of about 218,364 (416)
Increased accuracy of ligand sensing by receptor diffusion on cell surface [PDF]
Physical Review E 82, 041902 (2010), 2010 The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration.
arxiv +1 more source
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica +6 more
wiley +1 more source
The GABA-Withdrawal Syndrome: A Model of Local Status Epilepticus
Neural Plasticity, 2000 The GABA-withdrawal syndrome (GWS) is a model of local status epilepticus following the interruption of a chronic GABA infusion into the rat somatomotor cortex.
Carmen Silva-Barrat +2 more
doaj +1 more source
Activity-dependent modulation of neural circuit synaptic connectivity
Frontiers in Molecular Neuroscience, 2009 In many nervous systems, the establishment of neural circuits is known to proceed via a two-stage process; 1) early, activity-independent wiring to produce a rough map characterized by excessive synaptic connections, and 2) subsequent, use-dependent
Charles R Tessier, Kendal Broadie
doaj +1 more source
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Erwin A. van Vliet +9 more
wiley +1 more source
The role of neurosteroids in the pathogenesis of hepatic encephalopathy [PDF]
Medicinski Podmladak, 2016 Hepatic Encephalopathy (HE) represents a neuropsychiatric syndrome caused by acute or chronic liver failure. Hyperammonemia plays a pivotal role in the development of HE through modulation of neurotransmission, oxidative stress, neuroinflammation ...
Mladenović Dušan +2 more
doaj +1 more source
Relationships between Mitochondrial Dysfunction and Neurotransmission Failure in Alzheimer’s Disease
Aging and Disease, 2020 Besides extracellular deposition of amyloid beta and formation of phosphorylated tau in the brains of patients with Alzheimer’s disease (AD), the pathogenesis of AD is also thought to involve mitochondrial dysfunctions and altered neurotransmission ...
Kan Yin Wong +5 more
semanticscholar +1 more source
EMBO Molecular Medicine, 2018 Normal hearing and synaptic transmission at afferent auditory inner hair cell (IHC) synapses require otoferlin. Deafness DFNB9, caused by mutations in the OTOF gene encoding otoferlin, might be treated by transferring wild‐type otoferlin cDNA into IHCs ...
Hanan Al‐Moyed +5 more
doaj +1 more source
Neurexin directs partner-specific synaptic connectivity in C. elegans
eLife, 2018 In neural circuits, individual neurons often make projections onto multiple postsynaptic partners. Here, we investigate molecular mechanisms by which these divergent connections are generated, using dyadic synapses in C. elegans as a model.
Alison Philbrook +7 more
doaj +1 more source
Overexpressing temperature-sensitive dynamin decelerates phototransduction and bundles microtubules in drosophila photoreceptors [PDF]
, 2009 shibire(ts1), a temperature-sensitive mutation of the Drosophila gene encoding a Dynamin orthologue, blocks vesicle endocytosis and thus synaptic transmission, at elevated, or restrictive temperatures.
Gonzalez-Bellido, P.T. +4 more
core +1 more source