Results 41 to 50 of about 224,377 (390)

Metabolic flux and compartmentation analysis in the brain in vivo

Frontiers in Endocrinology, 2013
Through significant developments and progresses in the last two decades, in vivo localized nuclear magnetic resonance spectroscopy (MRS) became a method of choice to probe brain metabolic pathways in a non-invasive way.
Bernard eLanz, Rolf eGruetter, Rolf eGruetter, Rolf eGruetter, João M.N. Duarte, João M.N. Duarte   +5 more
doaj   +1 more source

Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis

eLife, 2020
Calcium (Ca2+)-evoked release of neurotransmitters from synaptic vesicles requires mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion following Ca2+-influx. The principal components involved in these processes are
Sathish Ramakrishnan, Manindra Bera, Jeff Coleman, James E Rothman, Shyam S Krishnakumar   +4 more
doaj   +1 more source

An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity

eLife, 2023
We still face fundamental gaps in understanding how molecular plastic changes of synapses intersect with circuit operation to define behavioral states. Here, we show that an antagonism between two conserved regulatory proteins, Spinophilin (Spn) and Syd ...
Niraja Ramesh, Marc Escher, Oriane Turrel, Janine Lützkendorf, Tanja Matkovic, Fan Liu, Stephan J Sigrist   +6 more
doaj   +1 more source

Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures [PDF]

, 2019
The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABAARs) at the appropriate synaptic sites.
Andrews, Peter M., Brandon, Nicholas J., Davies, Paul A., Hines, Rochelle M., Moore, Yvonne E., Moss, Stephen J., Nathanson, Anna J., Ollerhead, Thomas A., Rodriguez Santos, Miguel A., Smalley, Joshua L., Wobst, Heike J., Zhang, Yihui   +11 more
core   +2 more sources

Neuronal Dysfunction and Behavioral Abnormalities Are Evoked by Neural Cells and Aggravated by Inflammatory Microglia in Peroxisomal β-Oxidation Deficiency

Frontiers in Cellular Neuroscience, 2018
It is becoming evident that microglia, the resident immune cells of the central nervous system (CNS), are active contributors in neurological disorders.
Lien Beckers, Stijn Stroobants, Rudi D’Hooge, Myriam Baes   +3 more
doaj   +1 more source

Differential Myosin 5a splice variants in innervation of pelvic organs

Frontiers in Physiology, 2023
Introduction: Myosin proteins interact with filamentous actin and translate the chemical energy generated by ATP hydrolysis into a wide variety of mechanical functions in all cell types. The classic function of conventional myosins is mediation of muscle
Josephine A. Carew, Josephine A. Carew, Josephine A. Carew, Vivian Cristofaro, Vivian Cristofaro, Vivian Cristofaro, Raj K. Goyal, Raj K. Goyal, Maryrose P. Sullivan, Maryrose P. Sullivan, Maryrose P. Sullivan   +10 more
doaj   +1 more source

Involvement of Noradrenergic Neurotransmission in the Stress- but not Cocaine-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Role for β-2 Adrenergic Receptors [PDF]

, 2010
The responsiveness of central noradrenergic systems to stressors and cocaine poses norepinephrine as a potential common mechanism through which drug re-exposure and stressful stimuli promote relapse.
A Dzung Lê, AD Le, AH Tiong, AM Snoddy, AN Fricks-Gleason, Andy Weyer, AR Davis, AS Kreibich, B Lee, B Ribeiro Do Couto, B Wang, C Drouin, C Lanteri, C Orsini, CA Jiménez-Rivera, CA Rudoy, Chad E Beyer, CJ McDougle, D Highfield, D Weinshenker, David A Baker, DJ Macey, DJ Sanger, DM Platt, ED Abercrombie, F Leri, FH Gawin, G Bricca, GC Harris, GC Harris, HD Schmidt, Holly Caretta, J Stewart, JC Winter, JM Dwyer, JM Finlay, John R Mantsch, JR Schank, KM Kampman, KM Kampman, L Cervo, L Lu, LJ Vanderschuren, M Sofuoglu, M Sofuoglu, M Sofuoglu, ME Reith, MH Baumann, MJ Millan, MK Horne, MS Kleven, MW Feltenstein, MY Li, OA Tjurmina, Oliver Vranjkovic, PJ Fletcher, R Sinha, R Sinha, R Sinha, RD Spealman, RE Bernardi, RE Bernardi, RJ Smith, RM Eglen, S Deyama, S Erb, S Erb, S Erb, S Wee, SM Florin, T Belej, T Tanaka, T Watanabe, TC Rainbow, TJ Beveridge, TM Tzschentke, VA Redila, WL Woolverton, X Wang, XY Zhang, XY Zhang, Y Itzhak, Y Shaham, Y Shaham, Y Shaham, Y Shaham, ZJ Brown   +86 more
core   +3 more sources

Toxoplasma-Induced Hypermigration of Primary Cortical Microglia Implicates GABAergic Signaling

Frontiers in Cellular and Infection Microbiology, 2019
Toxoplasma gondii is a widespread obligate intracellular parasite that causes chronic infection and life-threatening acute infection in the central nervous system.
Amol K. Bhandage, Sachie Kanatani, Antonio Barragan   +2 more
doaj   +1 more source

A Role for the V0 Sector of the V-ATPase in Neuroexocytosis: Exogenous V0d Blocks Complexin and SNARE Interactions with V0c

Cells, 2023
V-ATPase is an important factor in synaptic vesicle acidification and is implicated in synaptic transmission. Rotation in the extra-membranous V1 sector drives proton transfer through the membrane-embedded multi-subunit V0 sector of the V-ATPase.
Christian Lévêque, Yves Maulet, Qili Wang, Marion Rame, Léa Rodriguez, Sumiko Mochida, Marion Sangiardi, Fahamoe Youssouf, Cécile Iborra, Michael Seagar, Nicolas Vitale, Oussama El Far   +11 more
doaj   +1 more source

Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray [PDF]

, 2017
The ventrolateral periaqueductal gray (vlPAG) constitutes a major descending pain modulatory system and is a crucial site for opioid-induced analgesia. A number of previous studies have demonstrated that glutamate and GABA play critical opposing roles in
Bruchas, Michael R, Copits, Bryan A, Gereau, Robert W, IV, Gomez, Adrian M, Grajales-Reyes, Jose G, O\u27Brien, Daniel E, Samineni, Vijay K, Trigg, Sarah L   +7 more
core   +2 more sources