Results 201 to 210 of about 415,134 (313)

Molecular Pathogenesis of Memory Impairment in Parkinson's Disease: An Exploration of Underlying Mechanisms. [PDF]

Health Sci Rep
Pourfridoni M, Hakemi Z, Mashayekhi-Sardoo H, Baghcheghi Y.   +3 more
europepmc   +1 more source

Cardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing

Annals of Neurology, EarlyView.
Objective Spinocerebellar ataxia 1 (SCA1) is a fatal hereditary neurodegenerative disorder with no approved therapies, and gene‐targeting strategies have thus far failed in clinical trials. Exercise remains the only intervention shown to provide clinical benefit in patients with spinocerebellar ataxias (SCAs), yet the underlying mechanisms remain ...
Isabel Soto, Michael Bonomo, Brianna S. Nelthrope, Benjamin D. Carr, Emma Palmer, Mariana Sierra, Ilkim Erturk, David Peppercorn, Eleonor Cox, Tiare K. Vasconcellos, Henry L. Paulson, Hannah K. Shorrock, Sharan R. Srinivasan   +12 more
wiley   +1 more source

Intrinsic regional brain activity differences and its relationship with neurotransmitter and gene expression in postpartum depression: a voxel-based meta-analysis. [PDF]

Psychol Med
Chen G, Tang X, Chen P, Chen R, Chen C, Zhang Y, Wang Z, Li F, Fei J, Lu D, Wang X, Xiao X, Wang Y, Huang X.   +13 more
europepmc   +1 more source

Gut–Brain Axis Modulation by Short‐Chain Fatty Acids Exerts Disease‐Modifying Effects in a Murine Model of Drug‐Resistant Epilepsy

Annals of Neurology, EarlyView.
Objective Drug‐resistant epilepsy (DRE) remains a clinical challenge, as therapies modifying disease trajectory are lacking. Increasing evidence implicates gut microbiota dysbiosis in epilepsy pathophysiology, with short‐chain fatty acids (SCFAs) emerging as key microbial metabolites with neuroprotective and anti‐inflammatory properties.
Akash A. Bera, Rossella Di Sapia, Greta Volpedo, Sneha Anand, Eray Sahin, Pasquale Baldassarre, Francesca Buffelli, Andrea Petretto, Chiara Lavarello, James D. Mills, Gabriele Cattaneo, Ilaria Craparotta, Eleonora Aronica, Antonella Riva, Pasquale Striano, Annamaria Vezzani, Teresa Ravizza   +16 more
wiley   +1 more source

Distinct Effects of Nonselective Rho-Kinase Inhibitor Fasudil and Selective Rho-Kinase 2 Inhibitor KD025 on Serotonin and Dopamine Release in the Nucleus Accumbens of Mice. [PDF]

Neuropsychopharmacol Rep
Tanaka R, Zhu W, Nagai T, Nabeshima T, Kaibuchi K, Ozaki N, Ikesue H, Mizoguchi H, Yamada K.   +8 more
europepmc   +1 more source

Serum neurotransmitter imbalances in benign paroxysmal positional vertigo: correlations with anxiety, depression, and sleep quality. [PDF]

Front Neurol
Zhang Q, She R, Zhou H, Guo J, Hu Z.
europepmc   +1 more source

Interdigitale Aptamer‐Sensoren mit komplementären Messkanälen zur schnellen Detektion kleiner Moleküle in Biofluiden

Angewandte Chemie, EarlyView.
Ein elektrochemischer Aptamer‐Sensorchip nutzt Interdigitalelektroden mit selektiver Monoschicht‐Funktionalisierung, um Dopamin und Cortisol mittels robuster komplementärer „Signal‐Off/On“‐Antworten zu detektieren. Diese Dual‐Channel‐Signalumwandlung ermöglicht eine schnelle Detektion innerhalb von 5–30 min bei geringen Probenvolumina in künstlicher ...
Senyao Wang, Ali Elmorsy, Defne Tüzün, Lilly Schmidt, Sebastian Freko, Lukas Hiendlmeier, Chen Wang, Alonso Ingar Romero, George Al Boustani, Hu Peng, Berna Özkale, Nako Nakatsuka, Bernhard Wolfrum   +12 more
wiley   +1 more source

The Role of the Ketogenic Diet in Modulating Biochemical Pathophysiology in Psychiatric and Neurodegenerative Disorders. [PDF]

Int J Mol Sci
Chang YB, Baleja JD.
europepmc   +1 more source

Gastrointestinal dysfunction in patients with Mowat-Wilson syndrome is associated with feeding difficulties and altered plasma neurotransmitters. [PDF]

Front Pediatr
Liu L, Wu L, Zhou R, Zhang Z, Xiao P, Li B, Li Q, Jiang Q, Wu J.   +8 more
europepmc   +1 more source

Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges

Angewandte Chemie International Edition, EarlyView.
Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley   +1 more source