G protein-coupled receptor signalling in astrocytes in health and disease: A focus on metabotropic glutamate receptors [PDF]
, 2012 Work published over the past 10–15 years has caused the neuroscience community to engage in a process of constant re-evaluation of the roles of glial cells in the mammalian central nervous system.
Bradley, Sophie J., Challiss, R.A. John
core +1 more source
Activity-dependent stochastic resonance in recurrent neuronal networks [PDF]
, 2008 We use a biophysical model of a local neuronal circuit to study the implications of synaptic plasticity for the detection of weak sensory stimuli. Networks with fast plastic coupling show behavior consistent with stochastic resonance. Addition of an additional slow coupling that accounts for the asynchronous release of neurotransmitter results in ...
arxiv +1 more source
The distribution of inhibitory neurons in the C. elegans connectome facilitates self-optimization of coordinated neural activity [PDF]
arXiv, 2020 The nervous system of the nematode soil worm Caenorhabditis elegans exhibits remarkable complexity despite the worm's small size. A general challenge is to better understand the relationship between neural organization and neural activity at the system level, including the functional roles of inhibitory connections.
arxiv
Liver Disease and Central Nervous System Dysfunction: Linking the Two - A Narrative Review
Journal of Education, Health and SportIntroduction: Liver dysfunction can significantly impact the central nervous system (CNS), leading to neuropsychiatric complications such as hepatic encephalopathy (HE).
Maciej Tenderenda +9 more
doaj +1 more source
Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016–2019)
Biomolecules, 2020 Acetylcholinesterase (AChE) is the key enzyme responsible for deactivating the ACh neurotransmitter. Irreversible or prolonged inhibition of AChE, therefore, elevates synaptic ACh leading to serious central and peripheral adverse effects which fall under
Alexandre A. de Castro +6 more
doaj +1 more source
Asymptotic and numerical analysis of a stochastic PDE model of volume transmission [PDF]
arXiv, 2018 Volume transmission is an important neural communication pathway in which neurons in one brain region influence the neurotransmitter concentration in the extracellular space of a distant brain region. In this paper, we apply asymptotic analysis to a stochastic partial differential equation model of volume transmission to calculate the neurotransmitter ...
arxiv
Sedative-like effect of intraperitoneal GABA administration in the open field test [PDF]
, 2016 Gamma-Amino Butyric Acid (GABA) is the main inhibitor neurotransmitter of the Central Nervous System (CNS). Its peripheral administration has been matter of discussion. On the one hand, it has been reported that it does not cross the Blood-Brain Barrier (
Gargiulo, Augusto Pascual Ítalo +7 more
core +1 more source
Pharmacotherapeutic aspects of dementia care in Malta [PDF]
, 2010 Dementia is the most common neurodegenerative disorder of old age affecting one percent of the local general population. It is a major predictor of morbidity and mortality in the elderly, adding a significant burden on health and social care systems ...
Abela, Stephen +2 more
core
Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice [PDF]
, 2005 BACKGROUND: Lantana camara L. (Verbenaceae), a widely growing shrub which is toxic to some animal species, has been used in the traditional medicine for treating many ailments.
Ojha, Sudarshan +2 more
core +2 more sources
arXiv, 2016 We consider the application of approximate Bayesian Computation (ABC) in the context of medical imaging data. We consider the parameter estimation of compartmental models in PET imaging analysis, and provide a simple ABC algorithm for its estimation. We demonstrate the utility of the proposed estimation methods on a neurotransmitter response model, and
arxiv