Results 131 to 140 of about 119,386 (177)

Discoveries of Neurotransmitter Agents and Modulators of Neuronal Functions

open access: closed, 1992
At a dinner speech in Atlantic City in 1950, Otto Loewi commented on some facets of his work that had led to the discovery of neurochemical transmission. He mentioned that Sir Walter Fletcher, years after the discovery, reminded him that as far back as 1903 Loewi had pointed out to him the possibility of a neurochemical transmission.
Ulf von Euler
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Multi-Faceted Aspects ofGamma-Hydroxybutyric Acid: A Neurotransmitter, Therapeutic Agent and Drug of Abuse

open access: closedMini-Reviews in Medicinal Chemistry, 2008
Gamma hydroxybutyric acid (GHB), an endogenous constituent of the mammalian brain, acts as i) a neurotransmitter or neuromodulator, ii) a medicine used for the treatment of narcolepsy and alcoholism, and iii) a drug illicitly used for its psychotropic effects. GHB is thought to act as a specific GHB receptor agonist as well as a weak gamma-aminobutyric
M. Paola Castelli
openalex   +4 more sources

Do Dual-Action Neurotransmitter Agents Offer an Advantage in Psychiatric Treatment?

open access: closedCNS Spectrums, 2001
ABSTRACTAntidepressant treatments have evolved over the last 20 years, and many new drugs with complex mechanisms of action are available. It has become apparent that mechanism of action is significant in terms of treatment impact. We may have some capacity to predict the potential outcomes of treatment based on what drugs we use. Depression management
Richard C. Shelton   +2 more
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Comparative effects of verapamil and D-600 on the contractile responses produced by neurotransmitters and depolarizing agents in the rat isolated seminal vesicle

open access: closedGeneral Pharmacology: The Vascular System, 1989
1. The comparative effects of verapamil and D-600, on isometric contractions produced by noradrenaline, acetylcholine, phenylephrine, clonidine, carbachol and high potassium, were studied in rat isolated seminal vesicle. 2. The aim was to see if verapamil and D-600 differed, in their selectivity, of blocking calcium, channels, and hence inhibition of ...
F. A. WALI, E. GREENIDGE
openalex   +3 more sources

Effects of Neurotransmitters and Neuropharmacological Agents on Phospholipid Metabolism in the Rabbit Iris Muscle

open access: closed, 1976
Since the original discovery of Hokin and Hokin1 that the application of acetyIcholine in the presence of eserine to cerebral cortex slices of guinea pigs greatly stimulated their incorporation of 32pi into certain phospholipids, which were later shown to be chiefly Phla and PhA, several investigators have confirmed this observation in a wide variety ...
Ata A. Abdel‐Latif
openalex   +3 more sources

Effect of various depolarizing agents on endogenous amino acid neurotransmitter release in rat cortical neurons in culture

open access: closedNeurochemistry International, 1998
The purpose of this study is to determine whether differences in membrane potential and/or intracellular Ca2+ increments are implicated in a programmed release of amino acid neurotransmitters (aspartate, glutamate, glycine and GABA) in cortical neurons in culture.
Miguel Herrero   +4 more
openalex   +3 more sources

Interaction of psychotropic agents with central neurotransmitters as revealed by their effects on PGO waves in the cat.

open access: closedArzneimittel-Forschung, 1976
One of the phasic phenomena of REM (rapid eye movement) sleep, the ponto-geniculo-occipital (PGO) waves, are induced in cats by either depleting brain monoamines with the benzoquinolizine derivative Ro 4-1284 or inhibiting the synthesis of 5-hydroxy-tryptamine (5-HT) by p-chlorophenylalanine (PCPA). The effects of the most important psychotropic agents
W Haefely   +3 more
openalex   +3 more sources

Neurotransmitters as Communicative Agents in Aquatic Ecosystems

open access: closedMoscow University Biological Sciences Bulletin, 2022
Alexander V. Oleskin, Andrey L. Postnov
openalex   +2 more sources

CENTRAL NEUROTRANSMITTERS AND ANAESTHETIC AGENTS

open access: closedProceedings of the Association of Veterinary Anaesthetists, 1980
David Lodge
openalex   +2 more sources

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