Results 131 to 140 of about 119,386 (177)
Discoveries of Neurotransmitter Agents and Modulators of Neuronal Functions
At a dinner speech in Atlantic City in 1950, Otto Loewi commented on some facets of his work that had led to the discovery of neurochemical transmission. He mentioned that Sir Walter Fletcher, years after the discovery, reminded him that as far back as 1903 Loewi had pointed out to him the possibility of a neurochemical transmission.
Ulf von Euler
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Gamma hydroxybutyric acid (GHB), an endogenous constituent of the mammalian brain, acts as i) a neurotransmitter or neuromodulator, ii) a medicine used for the treatment of narcolepsy and alcoholism, and iii) a drug illicitly used for its psychotropic effects. GHB is thought to act as a specific GHB receptor agonist as well as a weak gamma-aminobutyric
M. Paola Castelli
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Do Dual-Action Neurotransmitter Agents Offer an Advantage in Psychiatric Treatment?
ABSTRACTAntidepressant treatments have evolved over the last 20 years, and many new drugs with complex mechanisms of action are available. It has become apparent that mechanism of action is significant in terms of treatment impact. We may have some capacity to predict the potential outcomes of treatment based on what drugs we use. Depression management
Richard C. Shelton +2 more
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1. The comparative effects of verapamil and D-600, on isometric contractions produced by noradrenaline, acetylcholine, phenylephrine, clonidine, carbachol and high potassium, were studied in rat isolated seminal vesicle. 2. The aim was to see if verapamil and D-600 differed, in their selectivity, of blocking calcium, channels, and hence inhibition of ...
F. A. WALI, E. GREENIDGE
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Since the original discovery of Hokin and Hokin1 that the application of acetyIcholine in the presence of eserine to cerebral cortex slices of guinea pigs greatly stimulated their incorporation of 32pi into certain phospholipids, which were later shown to be chiefly Phla and PhA, several investigators have confirmed this observation in a wide variety ...
Ata A. Abdel‐Latif
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The purpose of this study is to determine whether differences in membrane potential and/or intracellular Ca2+ increments are implicated in a programmed release of amino acid neurotransmitters (aspartate, glutamate, glycine and GABA) in cortical neurons in culture.
Miguel Herrero +4 more
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One of the phasic phenomena of REM (rapid eye movement) sleep, the ponto-geniculo-occipital (PGO) waves, are induced in cats by either depleting brain monoamines with the benzoquinolizine derivative Ro 4-1284 or inhibiting the synthesis of 5-hydroxy-tryptamine (5-HT) by p-chlorophenylalanine (PCPA). The effects of the most important psychotropic agents
W Haefely +3 more
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Neurotransmitters as Communicative Agents in Aquatic Ecosystems
Alexander V. Oleskin, Andrey L. Postnov
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CENTRAL NEUROTRANSMITTERS AND ANAESTHETIC AGENTS
David Lodge
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