Results 151 to 160 of about 3,509,514 (361)

Centrally Acting Agents for Obesity: Past, Present, and Future

Drugs, 2018
Ann Coulter, Candida J. Rebello, F. Greenway   +2 more
semanticscholar   +1 more source

Harnessing Nonidealities in Analog In‐Memory Computing Circuits: A Physical Modeling Approach for Neuromorphic Systems

Advanced Intelligent Systems, EarlyView.
This work harnesses nonidealities in analog in‐memory computing (IMC) by training physical neural networks modeled with ordinary differential equations. A differentiable spike‐time discretization accelerates training by 20× and reduces memory usage by 100×, enabling large IMC‐equivalent models to learn the CIFAR‐10 dataset.
Yusuke Sakemi, Yuji Okamoto, Takashi Morie, Sou Nobukawa, Takeo Hosomi, Kazuyuki Aihara   +5 more
wiley   +1 more source

Serotonin (5‐Hydroxytryptamine): Metabolism, Signaling, Biological Functions, Diseases, and Emerging Therapeutic Opportunities

MedComm
Serotonin (5‐hydroxytryptamine; 5‐HT) is an evolutionarily conserved monoamine neurotransmitter that plays critical roles in various physiological systems, functioning as a neurotransmitter, hormone, and paracrine signaling molecule.
Yuxin Zhang, Nan Wang, Louqian Zhang, Yan Zhuang, Qilei Xin, Xiaosong Gu, Chunping Jiang, Junhua Wu   +7 more
doaj   +1 more source

Spinal Cord Trauma: An Overview of Normal Structure and Function, Primary and Secondary Mechanisms of Injury, and Emerging Treatment Modalities [PDF]

, 2018
The structures of the spinal cord and vertebral column are designed to provide flexibility, while still providing ample protection for the spinal cord deep within.
Morin, Daniel
core   +1 more source

Bioinspired Engineering beyond Homeostasis

Advanced Intelligent Systems, EarlyView.
This perspective article introduces systems biology as the unifying theoretical framework behind bioinspired engineering. As an example, it explores how disruptions in multiscale biological systems, associated with pathological states, can be viewed as localized failure modes of biological cooperation showing emergent advantages that can inspire ...
Rosalia Moreddu
wiley   +1 more source

Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons

, 2016
Sherry K. Pittman, Neilia G. Gracias, Jill C. Fehrenbacher   +2 more
openalex   +3 more sources

Cryogenic Neuromorphic Synaptic Behavior in 180 nm Silicon Transistors for Emerging Computing Systems

Advanced Intelligent Systems, EarlyView.
This study investigates the neuromorphic plasticity behavior of 180 nm bulk complementary metal oxide semiconductor (CMOS) transistors at cryogenic temperatures. The observed hysteresis data reveal a signature of synaptic behavior in CMOS transistors at 4 K.
Fiheon Imroze, Bhavani Yalagala, Naveen Kumar, Mostafa Elsayed, Meraj Ahmad, Robert Graham, Vihar Georgiev, Hadi Heidari, Martin Weides   +8 more
wiley   +1 more source

Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT In Attention Deficit Hyperactivity Disorder (ADHD), methylphenidate is one of the most widely used drugs, in which patient response significantly impacts prognosis. This study aimed to characterize the molecular profile of 10 genes associated with methylphenidate therapy.
Aline Pasquini Santos, Tatiane Carinta de Souza, Kaio Evandro Cardoso Aguiar, Ana Caroline Alves da Costa, Natasha Monte, Juliana Carla Gomes Rodrigues, Giovanna Gilioli da Costa Nunes, Rita de Cássia Calderaro Coelho, Ândrea Ribeiro‐dos‐Santos, André Maurício Ribeiro dos Santos, Sandro José de Souza, Sidney Emanuel Batista dos Santos, Rommel Mario Rodriguez Burbano, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +14 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Neurophysiological responses to stressful motion and anti-motion sickness drugs as mediated by the limbic system [PDF]

Performance is characterized in terms of attention and memory, categorizing extrinsic mechanism mediated by ACTH, norepinephrine and dopamine, and intrinsic mechanisms as cholinergic.
Kohl, R. L., Odell, S.
core   +1 more source