Results 151 to 160 of about 3,321,798 (216)

Modification of the anticonvulsant activity of 2-amino-5-phosphonovalerate by agents affecting different neurotransmitter systems

open access: closedNeuropharmacology, 1985
The effects of atropine (5 mg/kg), baclofen (10 mg/kg), gamma-hydroxybutyrate (300 mg/kg), gamma-butyrolactone (100 mg/kg) and muscimol (1 mg/kg) upon the action of 2-amino-5-phosphonovalerate (APV; an antagonist at receptors for N-methyl-D-aspartate) on the threshold current for seizures induced by electroshock, were studied in mice.
StanisÅ‚aw J. Czuczwar   +4 more
openalex   +4 more sources

Development of anti-obesity agents: drugs that target neuropeptide and neurotransmitter systems

open access: closedExpert Opinion on Investigational Drugs, 2008
Obesity results from an imbalance of energy intake and energy expenditure. While the prevalence of obesity is increasing and the negative impact on public health is being recognized, highly effective and safe therapy for obesity is not yet available.This review summarizes the current state of the art in the late-stage development area of anti-obesity ...
Tung M. Fong
openalex   +4 more sources

Cholinergic and Adrenergic Release Mechanism for Vasopressin in the Male Rat: A Study with Injections of Neurotransmitters and Blocking Agents into the Third Ventricle

open access: closedNeuroendocrinology, 1974
The injection into the 3rd ventricle of betha-nechol, carbachol and noradrenaline provoked the release of antidiuretic hormone (ADH) in the hydrated male rat, as indicated by a decrease in urine flow and free-water clearance, with an increased urinary electrolyte concentration, osmolality and conductivity.
E.R. K uuml hn
openalex   +4 more sources

CENTRAL NEUROTRANSMITTERS AND ANAESTHETIC AGENTS

open access: closedProceedings of the Association of Veterinary Anaesthetists, 1980
David Lodge
openalex   +3 more sources

Comparative effects of verapamil and D-600 on the contractile responses produced by neurotransmitters and depolarizing agents in the rat isolated seminal vesicle

open access: closedGeneral Pharmacology: The Vascular System, 1989
1. The comparative effects of verapamil and D-600, on isometric contractions produced by noradrenaline, acetylcholine, phenylephrine, clonidine, carbachol and high potassium, were studied in rat isolated seminal vesicle. 2. The aim was to see if verapamil and D-600 differed, in their selectivity, of blocking calcium, channels, and hence inhibition of ...
F. A. WALI, E. GREENIDGE
openalex   +4 more sources

Non-steroidal anti-inflammatory agents, tolmetin and sulindac, inhibit liver tryptophan 2,3-dioxygenase activity and alter brain neurotransmitter levels

open access: closedLife Sciences, 2006
Hepatic tryptophan 2,3-dioxygenase (TDO) is one of the rate-limiting enzymes in tryptophan catabolism and plays an important role in regulating the physiological flux of tryptophan into relevant metabolic pathways. In this study, we determined the effect of the non-steroidal anti-inflammatory agents, tolmetin and sulindac, on rat liver TDO activity and
Amichand Dairam   +3 more
openalex   +5 more sources

Interaction of psychotropic agents with central neurotransmitters as revealed by their effects on PGO waves in the cat.

open access: closedArzneimittel-Forschung, 1976
One of the phasic phenomena of REM (rapid eye movement) sleep, the ponto-geniculo-occipital (PGO) waves, are induced in cats by either depleting brain monoamines with the benzoquinolizine derivative Ro 4-1284 or inhibiting the synthesis of 5-hydroxy-tryptamine (5-HT) by p-chlorophenylalanine (PCPA). The effects of the most important psychotropic agents
W Haefely   +3 more
openalex   +3 more sources

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