Results 271 to 280 of about 165,229 (327)

Do Dual-Action Neurotransmitter Agents Offer an Advantage in Psychiatric Treatment?

CNS Spectrums, 2001
ABSTRACTAntidepressant treatments have evolved over the last 20 years, and many new drugs with complex mechanisms of action are available. It has become apparent that mechanism of action is significant in terms of treatment impact. We may have some capacity to predict the potential outcomes of treatment based on what drugs we use. Depression management
Richard C. Shelton, Dennis S. Charney, Madhukar H. Trivedi   +2 more
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Neurotoxic and Neurotrophic Effects of GABAergic Agents on Developing Neurotransmitter Systems

, 1998
Jean M. Lauder, Jiangping Liu
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Calcium channel types involved in intrinsic amino acid neurotransmitters release evoked by depolarizing agents in cortical neurons

Neurochemistry International, 2001
Although numerous biochemical and electrophysiological studies have already established many of the properties of the putative Ca2+ receptor for exocytosis at the synapse, the molecular mechanism that involves the influx of Ca2+ and the release of neurotransmitters has remained elusive.
Edith López, María Jesús Oset‐Gasque, S. Figueroa, J.J Albarrán, M.P. González   +4 more
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Endogenous neurotransmitters as anti-amigdaloidic agents: a density functional investigation of the interaction between melatonin and histidine

Journal of Molecular Structure: THEOCHEM, 2003
Abstract Recent insight has implicated the formation of β-amyloid fibril formation as a culpable process for the progression of Alzheimer's disease. Amyloid-β (Aβ) is a peptide naturally secreted by neurons in a random coil structure. It has been deduced that a conformational transition from a random coil to a β-pleated sheet is responsible for Aβ's ...
Luca F. Pisterzi, David R.P. Almeida, Donna M. Gasparro, Jason R. Juhasz, Botond Penke, Gyula Tasi, Imre G. Csizmadia   +6 more
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Multi-Faceted Aspects ofGamma-Hydroxybutyric Acid: A Neurotransmitter, Therapeutic Agent and Drug of Abuse

Mini-Reviews in Medicinal Chemistry, 2008
Gamma hydroxybutyric acid (GHB), an endogenous constituent of the mammalian brain, acts as i) a neurotransmitter or neuromodulator, ii) a medicine used for the treatment of narcolepsy and alcoholism, and iii) a drug illicitly used for its psychotropic effects. GHB is thought to act as a specific GHB receptor agonist as well as a weak gamma-aminobutyric
M. Paola Castelli
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Using the neurotransmitter serotonin to target imaging agents to glioblastoma cells

Investigational New Drugs, 2012
The neurotransmitter serotonin is involved in numerous bodily functions via seven different serotonin receptor subfamilies. Serotonin plays a role in gastrointestinal functions like intestinal secretion or peristalsis and neuropsychiatric events like depression or migraine.
Sturzu, Alexander, Sheikh, Sumbla, Klose, Uwe, Echner, Hartmut, Kalbacher, Hubert, Deeg, Martin, Horger, Marius, Ernemann, Ulrike, Heckl, Stefan, Nägele, Thomas   +9 more
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A catecholamine neurotransmitter: epinephrine as a CO₂ wet scrubbing agent

Chemical Communications, 2019
Adrenaline can be used to capture CO2 when dissolved in DMSO.
Ala'a F. Eftaiha, Farah M. Mustafa, Fatima Alsoubani, Khaleel I. Assaf, Abdussalam K. Qaroush   +4 more
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Modification of the anticonvulsant activity of 2-amino-5-phosphonovalerate by agents affecting different neurotransmitter systems

Neuropharmacology, 1985
The effects of atropine (5 mg/kg), baclofen (10 mg/kg), gamma-hydroxybutyrate (300 mg/kg), gamma-butyrolactone (100 mg/kg) and muscimol (1 mg/kg) upon the action of 2-amino-5-phosphonovalerate (APV; an antagonist at receptors for N-methyl-D-aspartate) on the threshold current for seizures induced by electroshock, were studied in mice.
Stanisław J. Czuczwar, L. Turski, Barbara Chmielewska, Waldemar A. Turski, Z Kleinrok   +4 more
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Effect of antidepressant agents on β-adrenergic receptor and neurotransmitter regulatory systems

Pharmacology Biochemistry and Behavior, 1980
Abstract The effects of established and several novel antidepressant agents on brain monoamine oxidase A and B; high affinity synaptosomal uptake of norepinephrine, dopamine and serotonin; and β-adrenergic receptor kinetics evaluated by (3H)-dihydroalprenolol binding to cortical membranes are described.
Laurence R. Meyerson, Lawrence L. Martin, Helen H. Ong, Daniel B. Ellis   +3 more
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Development of anti-obesity agents: drugs that target neuropeptide and neurotransmitter systems

Expert Opinion on Investigational Drugs, 2008
Obesity results from an imbalance of energy intake and energy expenditure. While the prevalence of obesity is increasing and the negative impact on public health is being recognized, highly effective and safe therapy for obesity is not yet available.This review summarizes the current state of the art in the late-stage development area of anti-obesity ...
Tung M. Fong
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