Results 251 to 260 of about 1,668,634 (294)
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Do Dual-Action Neurotransmitter Agents Offer an Advantage in Psychiatric Treatment?
CNS Spectrums, 2001ABSTRACTAntidepressant treatments have evolved over the last 20 years, and many new drugs with complex mechanisms of action are available. It has become apparent that mechanism of action is significant in terms of treatment impact. We may have some capacity to predict the potential outcomes of treatment based on what drugs we use. Depression management
Richard C. Shelton +2 more
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Journal of Neurochemistry, 1976
Abstract— The effects of 121 mm‐K+, 10 mm‐glutamate, 5 mm‐GABA, 1 mm‐glycine, 0.1 mm‐NE, and 1–10 μmACh on cyclic GMP levels in tissue slices prepared from cerebral cortex and cerebellum of mouse, rabbit, guinea‐pig, cat, and rat were studied. Basal levels of cyclic GMP in the cerebella of mice, guinea‐pigs and cats were 4–15 and 70 pmol/mg prot in rat,
D A, Kinscherf +4 more
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Abstract— The effects of 121 mm‐K+, 10 mm‐glutamate, 5 mm‐GABA, 1 mm‐glycine, 0.1 mm‐NE, and 1–10 μmACh on cyclic GMP levels in tissue slices prepared from cerebral cortex and cerebellum of mouse, rabbit, guinea‐pig, cat, and rat were studied. Basal levels of cyclic GMP in the cerebella of mice, guinea‐pigs and cats were 4–15 and 70 pmol/mg prot in rat,
D A, Kinscherf +4 more
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Arzneimittel-Forschung, 1976
One of the phasic phenomena of REM (rapid eye movement) sleep, the ponto-geniculo-occipital (PGO) waves, are induced in cats by either depleting brain monoamines with the benzoquinolizine derivative Ro 4-1284 or inhibiting the synthesis of 5-hydroxy-tryptamine (5-HT) by p-chlorophenylalanine (PCPA). The effects of the most important psychotropic agents
W, Haefely +3 more
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One of the phasic phenomena of REM (rapid eye movement) sleep, the ponto-geniculo-occipital (PGO) waves, are induced in cats by either depleting brain monoamines with the benzoquinolizine derivative Ro 4-1284 or inhibiting the synthesis of 5-hydroxy-tryptamine (5-HT) by p-chlorophenylalanine (PCPA). The effects of the most important psychotropic agents
W, Haefely +3 more
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Journal of Neurochemistry, 1999
Abstract : GABA, which is present in the brain in large amounts, is distributed among distinctly different cellular pools, possibly reflecting its multiple functions as metabolite, neurotransmitter, and neurotrophin. Its metabolic enzymes also exhibit heterogeneity, because glutamate decarboxylase exists in two isoforms with different subcellular ...
H S, Waagepetersen +2 more
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Abstract : GABA, which is present in the brain in large amounts, is distributed among distinctly different cellular pools, possibly reflecting its multiple functions as metabolite, neurotransmitter, and neurotrophin. Its metabolic enzymes also exhibit heterogeneity, because glutamate decarboxylase exists in two isoforms with different subcellular ...
H S, Waagepetersen +2 more
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The Journal of Pharmacology and Experimental Therapeutics, 1998
Isolated monkey cerebral arteries denuded of the endothelium responded to transmural electrical stimulation (5 Hz for 40 sec) with relaxations that are mediated by nitric oxide (NO) synthesized from L-arginine. The relaxant response was slightly inhibited by duroquinone, a superoxide anion-generating agent.
T, Okamura +3 more
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Isolated monkey cerebral arteries denuded of the endothelium responded to transmural electrical stimulation (5 Hz for 40 sec) with relaxations that are mediated by nitric oxide (NO) synthesized from L-arginine. The relaxant response was slightly inhibited by duroquinone, a superoxide anion-generating agent.
T, Okamura +3 more
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Neuropharmacology, 1985
The effects of atropine (5 mg/kg), baclofen (10 mg/kg), gamma-hydroxybutyrate (300 mg/kg), gamma-butyrolactone (100 mg/kg) and muscimol (1 mg/kg) upon the action of 2-amino-5-phosphonovalerate (APV; an antagonist at receptors for N-methyl-D-aspartate) on the threshold current for seizures induced by electroshock, were studied in mice.
S J, Czuczwar +4 more
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The effects of atropine (5 mg/kg), baclofen (10 mg/kg), gamma-hydroxybutyrate (300 mg/kg), gamma-butyrolactone (100 mg/kg) and muscimol (1 mg/kg) upon the action of 2-amino-5-phosphonovalerate (APV; an antagonist at receptors for N-methyl-D-aspartate) on the threshold current for seizures induced by electroshock, were studied in mice.
S J, Czuczwar +4 more
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Neuroscience & Biobehavioral Reviews, 1994
Gamma-hydroxybutyrate (GHB) is a catabolite in brain of gamma-aminobutyrate (GABA) and is also found in nonneuronal tissues. It is present in the brain at about one thousandth of the concentration of its parent compound. High affinity and specific uptake, and energy dependent transport systems for GHB have been described in brain in addition to a class
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Gamma-hydroxybutyrate (GHB) is a catabolite in brain of gamma-aminobutyrate (GABA) and is also found in nonneuronal tissues. It is present in the brain at about one thousandth of the concentration of its parent compound. High affinity and specific uptake, and energy dependent transport systems for GHB have been described in brain in addition to a class
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Neurochemistry International, 1998
The purpose of this study is to determine whether differences in membrane potential and/or intracellular Ca2+ increments are implicated in a programmed release of amino acid neurotransmitters (aspartate, glutamate, glycine and GABA) in cortical neurons in culture.
M T, Herrero +4 more
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The purpose of this study is to determine whether differences in membrane potential and/or intracellular Ca2+ increments are implicated in a programmed release of amino acid neurotransmitters (aspartate, glutamate, glycine and GABA) in cortical neurons in culture.
M T, Herrero +4 more
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Mini-Reviews in Medicinal Chemistry, 2008
Gamma hydroxybutyric acid (GHB), an endogenous constituent of the mammalian brain, acts as i) a neurotransmitter or neuromodulator, ii) a medicine used for the treatment of narcolepsy and alcoholism, and iii) a drug illicitly used for its psychotropic effects. GHB is thought to act as a specific GHB receptor agonist as well as a weak gamma-aminobutyric
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Gamma hydroxybutyric acid (GHB), an endogenous constituent of the mammalian brain, acts as i) a neurotransmitter or neuromodulator, ii) a medicine used for the treatment of narcolepsy and alcoholism, and iii) a drug illicitly used for its psychotropic effects. GHB is thought to act as a specific GHB receptor agonist as well as a weak gamma-aminobutyric
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Journal of Molecular Structure: THEOCHEM, 2003
Abstract Recent insight has implicated the formation of β-amyloid fibril formation as a culpable process for the progression of Alzheimer's disease. Amyloid-β (Aβ) is a peptide naturally secreted by neurons in a random coil structure. It has been deduced that a conformational transition from a random coil to a β-pleated sheet is responsible for Aβ's ...
Luca F. Pisterzi +6 more
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Abstract Recent insight has implicated the formation of β-amyloid fibril formation as a culpable process for the progression of Alzheimer's disease. Amyloid-β (Aβ) is a peptide naturally secreted by neurons in a random coil structure. It has been deduced that a conformational transition from a random coil to a β-pleated sheet is responsible for Aβ's ...
Luca F. Pisterzi +6 more
openaire +1 more source