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Discoveries of Neurotransmitter Agents and Modulators of Neuronal Functions
, 1992 At a dinner speech in Atlantic City in 1950, Otto Loewi commented on some facets of his work that had led to the discovery of neurochemical transmission. He mentioned that Sir Walter Fletcher, years after the discovery, reminded him that as far back as 1903 Loewi had pointed out to him the possibility of a neurochemical transmission.
Ulf von Euler
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Do Dual-Action Neurotransmitter Agents Offer an Advantage in Psychiatric Treatment?
CNS Spectrums, 2001 ABSTRACTAntidepressant treatments have evolved over the last 20 years, and many new drugs with complex mechanisms of action are available. It has become apparent that mechanism of action is significant in terms of treatment impact. We may have some capacity to predict the potential outcomes of treatment based on what drugs we use. Depression management
Richard C. Shelton +2 more
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Chemotherapeutic agents do not interact with neurotransmitter receptors
Cancer Chemotherapy and Pharmacology, 2004The interactions of cisplatin, 5-fluorouracil, doxorubicin, mitomycin, carmustine (BCNU), cyclophosphamide, methotrexate and thio-TEPA were assessed at three neurotransmitter receptor binding sites. Each drug was inactive at concentrations as high as 10(-4) M in displacing the specific binding of 3H-spiperone to dopamine D2, 3H-pyrilamine to histamine ...
S. Peroutka
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Species variation in the cerebrovascular response to neurotransmitters and related vasoactive agents
General Pharmacology: The Vascular System, 1983 Constrictory and dilatory responses of pial arteries to various receptor stimulants and modulators were evaluated in vitro and compared in rat, rabbit, cat and man. For the constrictory response, differences were noted especially in the rabbit, which responded strongly to histamine but poorly to noradrenaline and prostaglandin F2 alpha. Histamine was a
Jan Erik Hardebo, John Hanko, Ch. Owman
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Effect of antidepressant agents on β-adrenergic receptor and neurotransmitter regulatory systems
Pharmacology Biochemistry and Behavior, 1980 Abstract The effects of established and several novel antidepressant agents on brain monoamine oxidase A and B; high affinity synaptosomal uptake of norepinephrine, dopamine and serotonin; and β-adrenergic receptor kinetics evaluated by (3H)-dihydroalprenolol binding to cortical membranes are described.
Laurence R. Meyerson +3 more
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Mini-Reviews in Medicinal Chemistry, 2008 Gamma hydroxybutyric acid (GHB), an endogenous constituent of the mammalian brain, acts as i) a neurotransmitter or neuromodulator, ii) a medicine used for the treatment of narcolepsy and alcoholism, and iii) a drug illicitly used for its psychotropic effects. GHB is thought to act as a specific GHB receptor agonist as well as a weak gamma-aminobutyric
M. Paola Castelli
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Nature New Biology, 1973
Basal Level of Neurotransmitter Synthesizing Enzymes and Effect of Cyclic AMP Agents on the Morphological Differentiation of Isolated Neuroblastoma ...
K. Prasad +5 more
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Basal Level of Neurotransmitter Synthesizing Enzymes and Effect of Cyclic AMP Agents on the Morphological Differentiation of Isolated Neuroblastoma ...
K. Prasad +5 more
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Life Sciences, 1974 Abstract The effects of norepinephrine, other catecholamines, α- and β- adrenergic receptor blocking agents and acetylcholine on the incorporation of 32Pi into phospholipids of the iris muscle of the rabbit were studied in vitro . There was a marked stimulation of 32Pi into phosphatidic acid (PhA), phosphatidyl inositol (PhI) and to a much ...
Ata A. Abdel‐Latif
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Neurotransmitter Interactions and Responsivity to Cholinomimetic Agents
, 1992 There is now overwhelming evidence for the involvement of forebrain cholinergic systems in Alzheimer’s disease and the cognitive processes that subserve learning and memory (Perry et al., 1978; Bigl et al., 1987; Koshimura et al., 1987; Doucette et al., 1986; Ichimiya et al., 1986; Saper et al., 1985;Whitehouse, 1986; McGeer et al., 1984; Mann et al ...
Vahram Haroutunian +2 more
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Neuroscience & Biobehavioral Reviews, 1994 Gamma-hydroxybutyrate (GHB) is a catabolite in brain of gamma-aminobutyrate (GABA) and is also found in nonneuronal tissues. It is present in the brain at about one thousandth of the concentration of its parent compound. High affinity and specific uptake, and energy dependent transport systems for GHB have been described in brain in addition to a class
C. Cash
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