Results 291 to 300 of about 3,509,514 (361)
Development of anti-obesity agents: drugs that target neuropeptide and neurotransmitter systems
Expert Opinion on Investigational Drugs, 2008 Obesity results from an imbalance of energy intake and energy expenditure. While the prevalence of obesity is increasing and the negative impact on public health is being recognized, highly effective and safe therapy for obesity is not yet available.This review summarizes the current state of the art in the late-stage development area of anti-obesity ...
Tung M. Fong
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The Journal of Pharmacology and Experimental Therapeutics, 1998 Isolated monkey cerebral arteries denuded of the endothelium responded to transmural electrical stimulation (5 Hz for 40 sec) with relaxations that are mediated by nitric oxide (NO) synthesized from L-arginine. The relaxant response was slightly inhibited by duroquinone, a superoxide anion-generating agent.
Tomio Okamura +3 more
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Neuroendocrinology, 1974 The injection into the 3rd ventricle of betha-nechol, carbachol and noradrenaline provoked the release of antidiuretic hormone (ADH) in the hydrated male rat, as indicated by a decrease in urine flow and free-water clearance, with an increased urinary electrolyte concentration, osmolality and conductivity.
E.R. K uuml hn
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Journal of Molecular Structure: THEOCHEM, 2003 Abstract Recent insight has implicated the formation of β-amyloid fibril formation as a culpable process for the progression of Alzheimer's disease. Amyloid-β (Aβ) is a peptide naturally secreted by neurons in a random coil structure. It has been deduced that a conformational transition from a random coil to a β-pleated sheet is responsible for Aβ's ...
Luca F. Pisterzi +6 more
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Arzneimittel-Forschung, 1976 One of the phasic phenomena of REM (rapid eye movement) sleep, the ponto-geniculo-occipital (PGO) waves, are induced in cats by either depleting brain monoamines with the benzoquinolizine derivative Ro 4-1284 or inhibiting the synthesis of 5-hydroxy-tryptamine (5-HT) by p-chlorophenylalanine (PCPA). The effects of the most important psychotropic agents
W Haefely +3 more
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, 1976 Since the original discovery of Hokin and Hokin1 that the application of acetyIcholine in the presence of eserine to cerebral cortex slices of guinea pigs greatly stimulated their incorporation of 32pi into certain phospholipids, which were later shown to be chiefly Phla and PhA, several investigators have confirmed this observation in a wide variety ...
Ata A. Abdel‐Latif
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Changes in Neurotransmitter Values with Inhalational Agents
The Internet Journal of Anesthesiology, 2007 openalex +2 more sources
Neuropharmacology, 1984 The influence of naloxone (a narcotic antagonist), bicuculline (a GABA antagonist), phentolamine (an alpha-blocking agent), propranolol (a beta-adrenergic blocking agent), haloperidol (a dopaminergic blocking agent), methysergide (a serotonergic blocking agent) and atropine (a muscarinic blocking agent), on the antinociceptive effects induced by ...
Foong Foo-Wah
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General Pharmacology: The Vascular System, 1989 1. The comparative effects of verapamil and D-600, on isometric contractions produced by noradrenaline, acetylcholine, phenylephrine, clonidine, carbachol and high potassium, were studied in rat isolated seminal vesicle. 2. The aim was to see if verapamil and D-600 differed, in their selectivity, of blocking calcium, channels, and hence inhibition of ...
F. A. WALI, E. GREENIDGE
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