Results 41 to 50 of about 3,321,798 (216)
Serotonin—Its Synthesis and Roles in the Healthy and the Critically Ill
International Journal of Molecular Sciences, 2021 Serotonin (5-hydroxytryptamine, 5-HT) plays two important roles in humans—one central and the other peripheral—depending on the location of the 5-HT pools of on either side of the blood-brain barrier.
M. Káňová, P. Kohout
semanticscholar +1 more source
Mechanism of Allosteric Modulation of the Cys-loop Receptors
Pharmaceuticals, 2010 The cys-loop receptor family is a major family of neurotransmitter-operated ion channels. They play important roles in fast synaptic transmission, controlling neuronal excitability, and brain function.
Paul Whiteaker +2 more
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Distribution of Nitric Oxide-Producing Cells along Spinal Cord in Urodeles
Frontiers in Cellular Neuroscience, 2014 Nitric oxide is a unique neurotransmitter, which participates in many physiological and pathological processes in the organism. There are little data about the neuronal nitric oxide synthase immunoreactivity in the spinal cord of amphibians.
Mayada A Mahmoud +3 more
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Structure and Dynamics of the M3 Muscarinic Acetylcholine Receptor
Nature, 2012 Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subtypes (
A. Kruse +13 more
semanticscholar +1 more source
Smart Contrast Agents for Magnetic Resonance Imaging
CHIMIA, 2016 By visualizing bioactive molecules or biological parameters in vivo, molecular imaging is searching for information at the molecular level in living organisms.
Célia S. Bonnet, Éva Tóth
doaj +1 more source
Current Advances in Allosteric Modulation of Muscarinic Receptors
Biomolecules, 2020 Allosteric modulators are ligands that bind to a site on the receptor that is spatially separated from the orthosteric binding site for the endogenous neurotransmitter.
Jan Jakubik, Esam E. El-Fakahany
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ADMET and Druglikeness Calculations of Sarin, Soman, and Their Hypothetical Derivatives
Iraqi Journal of Industrial Research, 2022 Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) represents a numerical classification of any chemical to be a drug candidate with promising therapeutic efficacy with minimum toxicity or sensitivity depending on its chemical ...
Kafa Khalaf Hammud
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Neurotransmitter targeting in the treatment of depression.
Journal of Clinical Psychiatry, 2013 Residual symptoms are a common hindrance to daily life for patients with major depressive disorder. Even after antidepressant treatment has led patients to meet remission criteria, almost all patients have at least 1 symptom that remains unresolved ...
P. Blier
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Antioxidants, 2023 Oxidative catabolism of monoamine neurotransmitters by monoamine oxidases (MAOs) produces reactive oxygen species (ROS), which contributes to neuronal cells’ death and also lowers monoamine neurotransmitter levels.
Ahmed H. E. Hassan +14 more
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Neurotransmitter CART as a New Therapeutic Candidate for Parkinson’s Disease
Pharmaceuticals, 2013 Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. To date, there is no effective treatment that halts its progression. Increasing evidence indicates that mitochondria play an important role in the development of PD.
P. Mao +4 more
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