Results 41 to 50 of about 3,535,923 (362)

Serotonin—Its Synthesis and Roles in the Healthy and the Critically Ill

International Journal of Molecular Sciences, 2021
Serotonin (5-hydroxytryptamine, 5-HT) plays two important roles in humans—one central and the other peripheral—depending on the location of the 5-HT pools of on either side of the blood-brain barrier.
M. Káňová, P. Kohout
semanticscholar   +1 more source

Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases

Antioxidants, 2021
Neurotransmitter depletion and mitochondrial dysfunction are among the multiple pathological events that lead to neurodegeneration. Following our previous studies related with the development of multitarget mitochondriotropic antioxidants, this study ...
Daniel Chavarria, Ophelie Da Silva, Sofia Benfeito, Sandra Barreiro, Jorge Garrido, Fernando Cagide, Pedro Soares, Fernando Remião, Xavier Brazzolotto, Florian Nachon, Paulo J. Oliveira, José Dias, Fernanda Borges   +12 more
doaj   +1 more source

Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice [PDF]

, 2005
BACKGROUND: Lantana camara L. (Verbenaceae), a widely growing shrub which is toxic to some animal species, has been used in the traditional medicine for treating many ailments.
Ojha, Sudarshan, Sagar, Lenika, Sehgal, Rajesh   +2 more
core   +2 more sources

The influence of non-neuronal cells on catecholamine and acetylcholine synthesis and accumulation in cultures of dissociated sympathetic neurons [PDF]

, 1974
The effects of several non-neuronal cell types on neurotransmitter synthesis in cultures of dissociated sympathetic neurons from the new-born rat were studied.
Chun, Linda L. Y., Patterson, Paul H.
core   +1 more source

Folic acid as a potential therapeutic agent for Alzheimer's disease: Effects on inflammatory cytokines, amyloid deposition, and neurotransmitter metabolism

Journal of Medical Biochemistry
Background: Alzheimer's disease (AD) is a degenerative disease of the central nervous system characterized by neuroinflammation and amyloid deposition. Folic acid (FA), a B vitamin, may improve the course of AD by modulating inflammation and neuroprotection.
Jing Shao-wei, Yanqiu Wang, Yang Liu, Yi Luo, Xiaoqing Wen, Yao Ma, Hong Zhu, G L Chen, X. Ouyang   +8 more
openalex   +2 more sources

Mechanism of Allosteric Modulation of the Cys-loop Receptors

Pharmaceuticals, 2010
The cys-loop receptor family is a major family of neurotransmitter-operated ion channels. They play important roles in fast synaptic transmission, controlling neuronal excitability, and brain function.
Paul Whiteaker, Yao Huang, Yongchang Chang   +2 more
doaj   +1 more source

Pathophysiology, Therapeutic Targets, and Future Therapeutic Alternatives in COPD: Focus on the Importance of the Cholinergic System

Biomolecules, 2023
Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by airway limitation and changes in airway structure. It has a high global burden of mortality and morbidity.
Felisbela Gomes, Shih-Lung Cheng
doaj   +1 more source

A Fast-Slow Analysis of the Dynamics of REM Sleep

, 2012
Waking and sleep states are regulated by the coordinated activity of a number of neuronal population in the brainstem and hypothalamus whose synaptic interactions compose a sleep-wake regulatory network.
Booth, Victoria, Diniz Behn, Cecilia G.
core   +1 more source

The binding of botulinum neurotoxins to different peripheral neurons [PDF]

, 2017
Botulinum neurotoxins are the most potent toxins known. The double receptor binding modality represents one of the most significant properties of botulinum neurotoxins and largely accounts for their incredible potency and lethality.
Rossetto, O.
core   +1 more source

Emerging trends in pharmacological strategies for targeting neuroinflammation in depression [PDF]

Scripta Medica
The article discusses evolving pharmacological strategies for addressing the neuroinflammation in depression, highlighting its role in major depressive disorder.
Kumari Anshu, Sharma Rahul Kumar, Chopra Shivani, Chopra Hitesh   +3 more
doaj   +1 more source