Results 31 to 40 of about 1,668,634 (294)
Formal Verification of Neural Agents in Non-deterministic Environments [PDF]
, 2020 We introduce a model for agent-environment systems where the agents are implemented via feed-forward ReLU neural networks and the environment is non-deterministic. We study the verification problem of such systems against CTL properties.
Akintunde, Michael E. +4 more
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Neural Regeneration ResearchAlzheimer’s disease is a neurodegenerative disorder characterized by progressive cognitive decline, synaptic dysfunction, and neurotransmitter imbalance.
Siyuan Jin +5 more
doaj +1 more source
Mechanism of Allosteric Modulation of the Cys-loop Receptors
Pharmaceuticals, 2010 The cys-loop receptor family is a major family of neurotransmitter-operated ion channels. They play important roles in fast synaptic transmission, controlling neuronal excitability, and brain function.
Paul Whiteaker +2 more
doaj +1 more source
Antioxidants, 2021 Neurotransmitter depletion and mitochondrial dysfunction are among the multiple pathological events that lead to neurodegeneration. Following our previous studies related with the development of multitarget mitochondriotropic antioxidants, this study ...
Daniel Chavarria +12 more
doaj +1 more source
Neurotransmitter-Loaded Nanocapsule Triggers On-Demand Muscle Relaxation in Living Organism
, 2018 This paper reports the on-demand artificial muscle relaxation using a thermosensitive liposome encapsulating γ-aminobutyric acid (GABA) inhibitory neurotransmitter. Muscle relaxation is not feasible in principle, although muscle contraction can be easily
Ferdinandus +15 more
core +1 more source
Peripheral neurotransmitter metabolic signatures in schizophrenia: a targeted metabolomics study
Frontiers in PsychiatryObjectiveTo investigate peripheral metabolic alterations in patients with schizophrenia using a two-stage metabolomic workflow of untargeted analysis and targeted re-analysis,explore the associated metabolic pathways, identify potential peripheral ...
Bing Han +11 more
doaj +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers +19 more
wiley +1 more source
A Targeted Therapeutic Rescues Botulinum Toxin-A Poisoned Neurons [PDF]
, 2008 Botulinum neurotoxin (BoNT), a Category A biothreat agent, is the most potent poison known to mankind. Currently no antidote is available to rescue poisoned synapses.
Radharaman Ray +6 more
core