Results 31 to 40 of about 119,386 (177)

Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases

Antioxidants, 2021
Neurotransmitter depletion and mitochondrial dysfunction are among the multiple pathological events that lead to neurodegeneration. Following our previous studies related with the development of multitarget mitochondriotropic antioxidants, this study ...
Daniel Chavarria, Ophelie Da Silva, Sofia Benfeito, Sandra Barreiro, Jorge Garrido, Fernando Cagide, Pedro Soares, Fernando Remião, Xavier Brazzolotto, Florian Nachon, Paulo J. Oliveira, José Dias, Fernanda Borges   +12 more
doaj   +1 more source

Neuromodulation techniques targeting neurotransmitter dysfunction: Innovation in treatments for Alzheimer’s disease

Neural Regeneration Research
Alzheimer’s disease is a neurodegenerative disorder characterized by progressive cognitive decline, synaptic dysfunction, and neurotransmitter imbalance.
Siyuan Jin, Bingqi Guo, Wensi Hao, Xin Su, Tingting Zhang, Chunyan Liu   +5 more
doaj   +1 more source

Emerging trends in pharmacological strategies for targeting neuroinflammation in depression [PDF]

Scripta Medica
The article discusses evolving pharmacological strategies for addressing the neuroinflammation in depression, highlighting its role in major depressive disorder.
Kumari Anshu, Sharma Rahul Kumar, Chopra Shivani, Chopra Hitesh   +3 more
doaj   +1 more source

Pathophysiology, Therapeutic Targets, and Future Therapeutic Alternatives in COPD: Focus on the Importance of the Cholinergic System

Biomolecules, 2023
Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by airway limitation and changes in airway structure. It has a high global burden of mortality and morbidity.
Felisbela Gomes, Shih-Lung Cheng
doaj   +1 more source

Distribution of Nitric Oxide-Producing Cells along Spinal Cord in Urodeles

Frontiers in Cellular Neuroscience, 2014
Nitric oxide is a unique neurotransmitter, which participates in many physiological and pathological processes in the organism. There are little data about the neuronal nitric oxide synthase immunoreactivity in the spinal cord of amphibians.
Mayada A Mahmoud, Gehan Hassan Fahmy, Marie Z MOFTAH, Ismail eSabry   +3 more
doaj   +1 more source

Clinical Efficacy and Therapeutic Mechanism of Acupuncture in the Treatment of Adolescent Depression

Journal of Integrative Neuroscience
Background: Pharmacological treatment for adolescent depression is limited in safety and efficacy. Acupuncture treatment for depression has been endorsed by the World Health Organization.
Jinlan Jiang, Baohua Ji, Wei Jin, Peiyun Zhang, Haoran Chen, Wenjie Cong, Xiaoqing Jin, Lihong Li   +7 more
doaj   +1 more source

Treatment of Erectile Dysfunction: Update

American Journal of Men's Health, 2007
Erectile dysfunction (ED) is the inability to achieve and maintain an erection. Erectile function is dependent upon complex interactions of neural and vascular pathways.
Rupesh Raina, Geetu Pahlajani, Ashok Agarwal, Craig D. Zippe   +3 more
doaj   +1 more source

Smart Contrast Agents for Magnetic Resonance Imaging

CHIMIA, 2016
By visualizing bioactive molecules or biological parameters in vivo, molecular imaging is searching for information at the molecular level in living organisms.
Célia S. Bonnet, Éva Tóth
doaj   +1 more source

Screening of neurotransmitter receptor modulators reveals novel inhibitors of influenza virus replication

Frontiers in Cellular and Infection Microbiology
Influenza presents a significant public health threat, as severe cases can lead to excessive inflammation and complications such as pneumonia or acute respiratory distress syndrome.
Yarou Gao, Ge Liu, Yirui Ma, Yue Su, Xiaoqin Lian, Lefang Jiang, Jiaxin Ke, Xingjian Zhu, Mingxin Zhang, Yang Yu, Qun Peng, Wei Zhao, Wei Zhao, Xulin Chen   +13 more
doaj   +1 more source

Current Advances in Allosteric Modulation of Muscarinic Receptors

Biomolecules, 2020
Allosteric modulators are ligands that bind to a site on the receptor that is spatially separated from the orthosteric binding site for the endogenous neurotransmitter.
Jan Jakubik, Esam E. El-Fakahany
doaj   +1 more source