Results 41 to 50 of about 119,386 (177)

Platelet Function in Mood Disorders: Interplay, Clinical Implications, and Future Perspectives – A Narrative Review

Heart and Mind
Mood disorders, encompassing major depressive disorder and bipolar disorder, present complex etiologies involving neuroanatomical, neurotransmitter, and inflammatory mechanisms.
Ni He, Hanxiu Liu, Jing Liu, Xiqiang Wang, Junkui Wang, Hengwei Xu, Zhongwei Liu   +6 more
doaj   +1 more source

Blockade of Intranigral and Systemic D3 Receptors Stimulates Motor Activity in the Rat Promoting a Reciprocal Interaction among Glutamate, Dopamine, and GABA

Biomolecules, 2019
In vivo activation of dopamine D3 receptors (D3Rs) depresses motor activity. D3Rs are widely expressed in subthalamic, striatal, and dendritic dopaminergic inputs into the substantia nigra pars reticulata (SNr).
Marina Rodríguez-Sánchez, Rodrigo Erick Escartín-Pérez, Gerardo Leyva-Gómez, José Arturo Avalos-Fuentes, Francisco Javier Paz-Bermúdez, Santiago Iván Loya-López, Jorge Aceves, David Erlij, Hernán Cortés, Benjamín Florán   +9 more
doaj   +1 more source

Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. [PDF]

PLoS ONE, 2011
Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning.
Andrew C Hemmert, Tamara C Otto, Roberto A Chica, Monika Wierdl, Jonathan S Edwards, Steven M Lewis, Carol C Edwards, Lyudmila Tsurkan, C Linn Cadieux, Shane A Kasten, John R Cashman, Stephen L Mayo, Philip M Potter, Douglas M Cerasoli, Matthew R Redinbo   +14 more
doaj   +1 more source

Research Progress of PET Traces for Alzheimer’s Disease

Journal of Isotopes, 2014
Alzheimer’s disease (AD) is unknown cause progressive degenerative diseases of central nervous system. It is a serious threat to the health of the elderly people. The diagnosis is mainly based on pathological examination after death.
TANG Cai-hua1，2;HU Kong-zhen1;TANG Gang-hua1
doaj   +1 more source

Root Apex Transition Zone as Oscillatory Zone

Frontiers in Plant Science, 2013
Root apex of higher plants shows very high sensitivity to environmental stimuli. The root cap acts as the most prominent plant sensory organ; sensing diverse physical parameters such as gravity, light, humidity, oxygen and critical inorganic nutrients ...
Frantisek Baluska, Frantisek Baluska, Stefano Mancuso   +2 more
doaj   +1 more source

Evaluation of the efficacy of potential anesthetic agents on cuttlefish (Sepia pharaonis) juveniles

Aquaculture Reports, 2020
Anesthesia is often used to relieve stress and reduce mortality rates in aquaculture systems. Here, we assessed the efficacy of four anesthetic agents on cuttlefish (Sepia pharaonis) juveniles. Concentration-response trials were performed to evaluate the
Hua Yang, Yun Zhao, Weiwei Song, Yangfang Ye, Chunlin Wang, Changkao Mu, Ronghua Li   +6 more
doaj   +1 more source

A computational pipeline for a neurotransmitter-centric analysis of the effects of psychiatric medication on EEG spectral power

Frontiers in Psychiatry
IntroductionTraditional pharmaco-electroencephalography (EEG) studies have mainly examined the effects of psychotropic medications at the level of individual drugs or broad drug classes, limiting biological specificity and clinical translation.
Samar Samy Zekerallah, Anna Alexandra Maxion, Anna Alexandra Maxion, Jana Zweerings, Paula Teucher, Paula Teucher, Klaus Mathiak, Ekaterina Kutafina, Arnim Johannes Gaebler, Arnim Johannes Gaebler   +9 more
doaj   +1 more source

Cerebral low-molecular metabolites influenced by intestinal microbiota: a pilot study

Frontiers in Systems Neuroscience, 2013
Recent studies suggest that intestinal microbiota influences gut-brain communication. In this study, we aimed to clarify the influence of intestinal microbiota on cerebral metabolism. We analyzed the cerebral metabolome of germ-free (GF) mice and ex-germ-
Mitsuharu eMatsumoto, Ryoko eKibe, Takushi eOoga, Yuji eAiba, Emiko eSawaki, Yasuhiro eKoga, Yoshimi eBenno   +6 more
doaj   +1 more source

Current and Future Treatments in Alzheimer Disease: An Update

Journal of Central Nervous System Disease, 2020
Disease-modifying treatment strategies for Alzheimer disease (AD) are still under extensive research. Nowadays, only symptomatic treatments exist for this disease, all trying to counterbalance the neurotransmitter disturbance: 3 cholinesterase inhibitors
Konstantina G Yiannopoulou, Sokratis G Papageorgiou   +1 more
doaj   +1 more source

Psychobiotic Effects of Postbiotics in Depression, Psychosis and Mania [PDF]

Health Promotion Perspectives
Background: The gut microbiota significantly influences mental health through the gut-brain axis, modulating mood, cognition, and emotional regulation. While probiotics and prebiotics have been widely studied for their psychobiotic effects, postbiotics ...
Aziz Homayouni-Rad, Jalil Houshyar, Hossein Alikhah, Saba Kamalledin Moghadam, Zohreh Osouli, Ali Asgharzadeh, Vahideh Sarabi-Aghdam, Alireza Asghari   +7 more
doaj   +1 more source