Results 21 to 30 of about 119,386 (177)

Disminución del número de neuronas que expresan GABA en la corteza cerebral de ratones infectados con rabia

Biomédica: revista del Instituto Nacional de Salud, 2007
Introducción. Algunos signos clínicos de la rabia y estudios experimentales previos sugieren que esta infección viral podría afectar al sistema GABAérgico. Objetivo. Evaluar el efecto de la infección con el virus de la rabia sobre la expresión de GABA en
Aura Caterine Rengifo, Orlando Torres-Fernández   +1 more
doaj   +1 more source

Cognitive Decline in Neuronal Aging and Alzheimer's Disease: Role of NMDA Receptors and Associated Proteins

Frontiers in Neuroscience, 2017
Molecular changes associated with neuronal aging lead to a decrease in cognitive capacity. Here we discuss these alterations at the level of brain regions, brain cells, and brain membrane and cytoskeletal proteins with an special focus in NMDA molecular ...
Jesús Avila, Jesús Avila, María Llorens-Martín, María Llorens-Martín, Noemí Pallas-Bazarra, Noemí Pallas-Bazarra, Marta Bolós, Marta Bolós, Juan R. Perea, Juan R. Perea, Alberto Rodríguez-Matellán, Alberto Rodríguez-Matellán, Félix Hernández, Félix Hernández   +13 more
doaj   +1 more source

Robot technology identifies a Parkinsonian therapeutics repurpose to target stem cells of glioblastoma

CNS Oncology, 2020
Aim: Glioblastoma is a heterogeneous lethal disease, regulated by a stem-cell hierarchy and the neurotransmitter microenvironment. The identification of chemotherapies targeting individual cancer stem cells is a clinical need.
Andres Vargas-Toscano, Dilaware Khan, Ann-Christin Nickel, Michael Hewera, Marcel Alexander Kamp, Igor Fischer, Hans-Jakob Steiger, Wei Zhang, Sajjad Muhammad, Daniel Hänggi, Ulf Dietrich Kahlert   +10 more
doaj   +1 more source

Blood platelet research in autism spectrum disorders: In search of biomarkers

Research and Practice in Thrombosis and Haemostasis, 2019
Autism spectrum disorder (ASD) is a clinically heterogeneous neurodevelopmental disorder that is caused by gene‐environment interactions. To improve its diagnosis and treatment, numerous efforts have been undertaken to identify reliable biomarkers for ...
Manisha Padmakumar, Eveline Van Raes, Chris Van Geet, Kathleen Freson   +3 more
doaj   +1 more source

Neurochemical Modulating Effect of Boswellia serrata Roxb. ex Colebr: A Preclinical Research

Pharmaceutical and Biomedical Research, 2022
Background: Boswellia serrata has been known for many decades and mentioned in the ancient Ayurvedic texts. Many previous studies have demonstrated its role in depression and anxiety in animal models.
Prabhakar Adake, Mahalaxmi S Petimani, Greeshma B Kotian   +2 more
doaj  

Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders

Behavioral Sciences, 2014
Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to modulate, dopaminergic and other neurotransmitter systems involved in the pathophysiology of various mental disorders.
Mona M Boules, Paul Fredrickson, Amber M Muehlmann, Elliott Richelson   +3 more
doaj   +1 more source

The Relationship Between Dopamine Neurotransmitter Dynamics and the Blood-Oxygen-Level-Dependent (BOLD) Signal: A Review of Pharmacological Functional Magnetic Resonance Imaging

Frontiers in Neuroscience, 2018
Functional magnetic resonance imaging (fMRI) is widely used in investigations of normal cognition and brain disease and in various clinical applications. Pharmacological fMRI (pharma-fMRI) is a relatively new application, which is being used to elucidate
Tyler J. Bruinsma, Vidur V. Sarma, Vidur V. Sarma, Yoonbae Oh, Yoonbae Oh, Dong Pyo Jang, Su-Youne Chang, Su-Youne Chang, Greg A. Worrell, Val J. Lowe, Hang Joon Jo, Hang Joon Jo, Hoon-Ki Min, Hoon-Ki Min, Hoon-Ki Min   +14 more
doaj   +1 more source

Quantitative Structure-Activity Relationship (QSAR) Studies and Molecular docking Simulation of Norepinephrine Transporter (NET) Inhibitors as Anti-psychotic Therapeutic Agents

Journal of the Turkish Chemical Society, Section A: Chemistry, 2020
The Norepinephrine transporter (NET) is a Na+/Cl- coupled neurotransmitter transporter responsible for reuptake of released norepinephrine (NE) into neural terminals in the brain, an important therapeutic agent used in the treatment of psychiatric ...
Sabitu Babatunde OLASUPO, Adamu UZAIRU, Gideon SHALLANGWA, Sani UBA   +3 more
doaj   +1 more source

Mechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology

Pharmaceutical Biology, 2022
Context Lily bulb and Rehmannia decoction (LBRD), consisting of Lilium henryi Baker (Liliaceae) and Rehmannia glutinosa (Gaertn) DC (Plantaginaceae), is a specialized traditional Chinese medicine formula for treating depression.
Xiansu Chi, Xiaoyan Xue, Jin Pan, Jiang Wu, Huishan Shi, Yong Wang, Yanting Lu, Zhe Zhang, Ke Ma   +8 more
doaj   +1 more source

Mechanism of Allosteric Modulation of the Cys-loop Receptors

Pharmaceuticals, 2010
The cys-loop receptor family is a major family of neurotransmitter-operated ion channels. They play important roles in fast synaptic transmission, controlling neuronal excitability, and brain function.
Paul Whiteaker, Yao Huang, Yongchang Chang   +2 more
doaj   +1 more source