Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma. [PDF]
PLoS ONE, 2011 BACKGROUND: Frontline treatment of small cell lung carcinoma (SCLC) relies heavily on chemotherapeutic agents and radiation therapy. Though SCLC patients respond well to initial cycles of chemotherapy, they eventually develop resistance.
Ma Reina D Improgo +3 more
doaj +7 more sources
A computational pipeline for a neurotransmitter-centric analysis of the effects of psychiatric medication on EEG spectral power [PDF]
Frontiers in PsychiatryIntroductionTraditional pharmaco-electroencephalography (EEG) studies have mainly examined the effects of psychotropic medications at the level of individual drugs or broad drug classes, limiting biological specificity and clinical translation.
Samar Samy Zekerallah +9 more
doaj +2 more sources
Neurotransmitters in cancer: how receptor signaling and posttranslational modifications modulate tumor progression and offer new therapeutic targets [PDF]
Cell Communication and SignalingRecent studies highlight the multifaceted roles of neurotransmitters in tumor immunomodulation, offering novel avenues for increasing therapeutic efficacy.
Xuanyin Ding +9 more
doaj +2 more sources
Guiding AlphaFold to predict how Munc13-1 opens Syntaxin-1. [PDF]
FEBS Open BioThe syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Chattopadhyay M, Xu J, Rizo J.
europepmc +2 more sources
Antiepileptic potential of ganaxolone [PDF]
Vojnosanitetski Pregled, 2017 nema
Janković Slobodan, Lukić Snežana
doaj +1 more source
Creatine Activity as a Neuromodulator in the Central Nervous System [PDF]
Archives of Razi Institute, 2023 Creatine is a nutritional compound that potentially influences cognitive processing and neuroprotection. Recent evidence has demonstrated that similar to neurotransmitters, creatine is released in an excitotoxic and action potential-dependent manner and ...
G. H Meftahi, B Hatef, G Pirzad Jahromi
doaj +1 more source
Plastic reorganisation of human motor cortex [PDF]
Vojnosanitetski Pregled, 2012 nema
Ilić Tihomir V., Ilić Nela V.
doaj +1 more source
Total ganglioside ablation at mouse motor nerve terminals alters neurotransmitter release level [PDF]
, 2010 Neuronal membrane gangliosides, forming a large family of sialylated glycosphingolipids, have been hypothesized to play important roles in synaptic transmission.
Furukawa, K. +4 more
core +2 more sources
Reviewing the mechanism of propofol addiction
All Life, 2023 Propofol is widely used as a short-acting intravenous anaesthetic for the induction and maintenance of anaesthetic sedation. The application of propofol is expanding due to its advantages and the increasing demand for painless diagnosis and treatment ...
Tianhao Zhong +5 more
doaj +1 more source
Ontology acquisition and exchange of evolutionary product-brokering agents [PDF]
, 2004 Agent-based electronic commerce (e-commerce) has been booming with the development of the Internet and agent technologies. However, little effort has been devoted to exploring the learning and evolving capabilities of software agents.
Guan, SU, Zhu, F
core +6 more sources