Results 61 to 70 of about 3,321,798 (216)

Reliability of behavioral test with fish: How neurotransmitters may exert neuromodulatory effects and alter the biological responses to neuroactive agents

Science of The Total Environment, 2020
Toxic agents such as pharmaceuticals and pesticides are continuously dispersed especially in the aquatic environment, as a result of human use. Their presence in the environment presents serious concerns, since these compounds interfere with the normal function of the central nervous system (CNS), causing behavior alterations, whose consequences are ...
Sousa, Beatriz, Nunes, Bruno
openaire   +4 more sources

Structure and Function of the Benzodiazepine Receptor

CHIMIA, 1987
Benzodiazepine tranquilizers are the most frequently therapeutically used psychotropic agents since their introduction in I960. Since 1974 research on the mechanism of action of agents acting on the specific benzodiazepine receptors (BZR) has been one ...
Willy E. Haefely
doaj   +1 more source

Crystal Structure of Human Butyrylcholinesterase and of Its Complexes with Substrate and Products*

Journal of Biological Chemistry, 2003
Cholinesterases are among the most efficient enzymes known. They are divided into two groups: acetylcholinesterase, involved in the hydrolysis of the neurotransmitter acetylcholine, and butyrylcholinesterase of unknown function.
Y. Nicolet, O. Lockridge, P. Masson, J. Fontecilla-Camps, F. Nachon   +4 more
semanticscholar   +1 more source

Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016–2019)

Biomolecules, 2020
Acetylcholinesterase (AChE) is the key enzyme responsible for deactivating the ACh neurotransmitter. Irreversible or prolonged inhibition of AChE, therefore, elevates synaptic ACh leading to serious central and peripheral adverse effects which fall under
Alexandre A. de Castro, Letícia C. Assis, Flávia V. Soares, Kamil Kuca, Daniel A. Polisel, Elaine F. F. da Cunha, Teodorico C. Ramalho   +6 more
doaj   +1 more source

Liver Disease and Central Nervous System Dysfunction: Linking the Two - A Narrative Review

Journal of Education, Health and Sport
Introduction: Liver dysfunction can significantly impact the central nervous system (CNS), leading to neuropsychiatric complications such as hepatic encephalopathy (HE).
Maciej Tenderenda, Bartosz Buczkowski, Piotr Oleksy, Agnieszka Klecza, Aleksandra Broniak, Magdalena Reclik, Karol Zieliński, Aarushi Chourasia, Krzysztof Nowakowski, Martyna Chraścina   +9 more
doaj   +1 more source

Role of VEGF, Nitric Oxide and sympathetic neurotransmitters in the pathogenesis of tendinopathy: a review of the current evidences

Frontiers in Aging Neuroscience, 2016
Chronic tendinopathy is a painful common condition affecting athletes as well as the general population undergoing to tendon overuse. Although its huge prevalence, little is known about tendinopathy pathogenesis, and even cloudier is its treatment ...
Sebastiano Vasta, Alberto Di Martino, Biagio Zampogna, Guglielmo Torre, Rocco Papalia, Vincenzo Denaro   +5 more
doaj   +1 more source

Drosophila modifier screens to identify novel neuropsychiatric drugs including aminergic agents for the possible treatment of Parkinson’s disease and depression

Molecular Psychiatry, 2012
Small molecules that increase the presynaptic function of aminergic cells may provide neuroprotection in Parkinson’s disease (PD) as well as treatments for attention deficit hyperactivity disorder (ADHD) and depression.
H. Lawal, A. Terrell, H. Lam, Christine Djapri, J. Jang, Richard Hadi, Logan Roberts, Varun Shahi, Man-Ting Chou, Traci Biedermann, B. Huang, G. Lawless, N. Maidment, D. Krantz   +13 more
semanticscholar   +1 more source

Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide

F1000Research, 2018
Therapeutic medications for the treatment of depression have serious limitations, particularly delayed onset and low rates of efficacy. However, the discovery that a single subanesthetic dose of ketamine, a glutamate NMDA receptor channel blocker, can ...
R. Duman
semanticscholar   +1 more source

Convergence and divergence of neurotransmitter action in human cerebral cortex.

Proceedings of the National Academy of Sciences of the United States of America, 1989
The postsynaptic actions of acetylcholine, adenosine, gamma-aminobutyric acid, histamine, norepinephrine, and serotonin were analyzed in human cortical pyramidal cells maintained in vitro.
D. McCormick, A. Williamson
semanticscholar   +1 more source

Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management

Neuropsychiatric Disease and Treatment, 2010
Michele Fornaro, Matteo MartinoDepartment of Neuroscience, Section of Psychiatry, University of Genova, Genova, ItalyBackground: Subjective tinnitus is a frequent, impairing condition, which may also cause neurotransmitter imbalance at the cochlea ...
Michele Fornaro, Matteo Martino
doaj