Results 81 to 90 of about 156,401 (247)
Integrating Preclinical and Clinical Models of Negative Urgency [PDF]
, 2019 Overwhelming evidence suggests that negative urgency is robustly associated with rash, ill-advised behavior, and this trait may hamper attempts to treat patients with substance use disorder.
Argyriou, Evangelia +2 more
core +2 more sources
Molecular Quantum (MolQ) Communication Channel in the Gut-Brain Axis Synapse [PDF]
IEEE Transactions on Molecular, Biological, and Multi-Scale
Communications (2024)The gut-brain axis is the communication link between the gut and the brain. Although it is known that the gut-brain axis plays a pivotal role in homeostasis, its overall mechanism is still not known. However, for neural synapses, classical molecular communication is described by the formation of ligand-receptor complexes, which leads to the opening of ...
arxiv +1 more source
Long-Lived States of Methylene Protons in Achiral Molecules [PDF]
arXiv, 2022 It is shown that long-lived states (LLS) involving pairs of methylene protons in nuclear magnetic resonance (NMR) can be readily excited in common molecules that contain two or more neighboring CH$_2$ groups. Accessing such LLS does not require any isotopic enrichment, nor does it require any stereogenic centers to lift the chemical equivalence of CH ...
arxiv
Current and Future Treatments in Alzheimer Disease: An Update
Journal of Central Nervous System Disease, 2020 Disease-modifying treatment strategies for Alzheimer disease (AD) are still under extensive research. Nowadays, only symptomatic treatments exist for this disease, all trying to counterbalance the neurotransmitter disturbance: 3 cholinesterase inhibitors
Konstantina G Yiannopoulou +1 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2016 Chronic tendinopathy is a painful common condition affecting athletes as well as the general population undergoing to tendon overuse. Although its huge prevalence, little is known about tendinopathy pathogenesis, and even cloudier is its treatment ...
Sebastiano Vasta +5 more
doaj +1 more source
The role of the neuromodulator adenosine in alcohols actions. [PDF]
, 1997 The interaction between the neuromodulator adenosine and adenosine receptors on the surface of neurons modifies the neurons responses to neurotransmitters.
Diamond, Ivan, Dohrman, D, Gordon, A
core
Ca2+ transients are not required as signals for long-term neurite outgrowth from cultured sympathetic neurons [PDF]
, 1990 A method for clamping cytosolic free Ca2+ ([Ca2+]i) in cultures of rat sympathetic neurons at or below resting levels for several days was devised to determine whether Ca2+ signals are required for neurite outgrowth from neurons that depend on Nerve ...
Murrell, R D +3 more
core +2 more sources
Structure and Function of the Benzodiazepine Receptor
CHIMIA, 1987 Benzodiazepine tranquilizers are the most frequently therapeutically used psychotropic agents since their introduction in I960. Since 1974 research on the mechanism of action of agents acting on the specific benzodiazepine receptors (BZR) has been one ...
Willy E. Haefely
doaj +1 more source
Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]
, 2019 Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core
Quantitative pharmacologic MRI: Mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice [PDF]
, 2011 The use of pharmacologic MRI (phMRI) in mouse models of brain disorders allows noninvasive in vivo assessment of drug-modulated local cerebral blood volume changes (ΔCBV) as one correlate of neuronal and neurovascular activities.
Demyanenko, Andrey V. +5 more
core +2 more sources