Results 61 to 70 of about 169,266 (282)

Drugs Affecting 5-HT Systems [PDF]

, 2013
Seminar transcriptIt was in the very early hours of a February morning in 1977 that I first looked down the microscope and saw yellow fluorescence, characteristic of 5-hydroxytryptamine (5-HT) in frozen sections of Octopus brain. After struggling for two
Overy, C, Tansey, EM
core  

Harnessing the power of cell transplantation to target respiratory dysfunction following spinal cord injury. [PDF]

, 2017
The therapeutic benefit of cell transplantation has been assessed in a host of central nervous system (CNS) diseases, including disorders of the spinal cord such as traumatic spinal cord injury (SCI).
Charsar, Brittany A., Lepore, Angelo C., Urban, Mark W.   +2 more
core   +2 more sources

Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin‐Like Peptide in Bactrocera Dorsalis

Advanced Science, EarlyView.
This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li, Bao Dong, Zheng‐Lin Ren, Xue‐Guang Zhu, Quan Lei, Yoonseong Park, Jin‐Jun Wang, Hong‐Bo Jiang   +7 more
wiley   +1 more source

Understanding the molecular pharmacology of the serotonergic system : using fluoxetine as a model [PDF]

, 2011
Objectives: Serotonin is a monoamine neurotransmitter that is widely distributed in the body and plays an important role in a variety of psychological and other body functions such as mood, sexual desire and function, appetite, sleep, memory and learning,
Mifsud, Janet, Sghendo, Lino
core   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important [PDF]

, 2015
Kynurenine pathway, the quantitatively main branch of tryptophan metabolism, has been long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to ...
CURTO, MARTINA, FAZIO, FRANCESCO, Lionetto, L, MARTELLETTI, Paolo, Mitsikostas, Dd   +4 more
core   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Astrocytic transporters in Alzheimer's disease [PDF]

, 2016
Astrocytes play a fundamental role in maintaining the health and function of the central nervous system. Increasing evidence indicates that astrocytes undergo both cellular and molecular changes at an early stage in neurological diseases, including ...
Abdul, Ahmed, Alexander, Alexander, Almeida, Amara, Aroeira, Assal, Augustin, Banerjee, Bareggi, Bates, Beart, Beaugé, Beckstrøm, Bjørnsen, Blakely, Boehm-Cagan, Boehm-Cagan, Bolaños, Borden, Bouvier, Bowen, Boycott, Boyden, Brekke, Bridges, Broccardo, Brown, Burkhalter, Busch, Bussière, Butterfield, Cahoy, Carageorgiou, Casper, Chauhan, Chen, Chen, Chen, Chen, Chiang, Cirrito, Coco, Colton, Crambert, Cudkowicz, Cunnane, Dallas, Danbolt, Dawson, De Strooper, Dickey, Dienel, Dolińska, Dong, Duerson, Dunlop, Eulenburg, Figueiredo, Fontana, Fotiadis, Francis, Fu, Fuller, Gannon, Garcia-Alloza, Genda, Gottesman, Graham, Hafiane, Halestrap, Hanu, Harada, Hardie, Hardy, Harik, Harris, Hartz, Hattori, Haydon, Heneka, Hermenegildo, Hewett, Hill, Hirrlinger, Hirst, Hollingworth, Hsu, Hu, Hu, Huang, Huang, Huey, Hynd, Imfeld, Inazu, Israel, Jacob, Jankowsky, Jensen, Jeynes, Jiang, Juopperi, Kandimalla, Kaplan, Kapogiannis, Katz, Katz, Kepe, Kim, Kim, Kim, Kim, Kirischuk, Koch, Kondo, Kong, Kong, Krencik, Krencik, Kristensen, Kruh, Kulijewicz-Nawrot, Kunugi, Kurella, Köfalvi, Lam, Lee, Lee, Lee, Lent, Lewerenz, Lewerenz, Li, Li, Li, Liu-Seifert, Lombardo, Luurtsema, Malynn, Maragakis, Maragakis, Maragos, Marner, Marroni, Masliah, Masliah, Massie, McGrail, Mehta, Mercier, Mergenthaler, Merlini, Mesci, Michikawa, Middeldorp, Mirbolooki, Moechars, Mohler, Mookherjee, Mooradian, Morrissette, Mosconi, Mosconi, Mosconi, Moseley, Mota, Mueckler, Nakagawa, Niccoli, Nies, Nijland, Oddo, Ohnishi, Olabarria, Olabarria, Oliveira, Oliveira, Orr, Orre, Palmer, Palmer, Pellerin, Pellerin, Pellerin, Peng, Pierre, Pirttimaki, Polanski, Pow, Pow, Raiteri, Rambo, Ramirez, Richerson, Rodriguez-Vieitez, Rose, Rose, Rothstein, Sakae, Sato, Savolainen, Schallier, Schousboe, Schousboe, Schwab, Sevigny, Shih, Shih, Simpson, Simpson, Simpson, Sofroniew, Son, Soontornmalai, Soucek, Sultana, Suzuki, Sweadner, Tadi, Tajeddinn, Tajeddinn, Takahashi, Tanaka, Tang, Thöne-Reineke, Timmer, Tomi, Tong, Tsang, Upton, Van Dam, van Neerven, Vandenberg, Vannucci, Vemula, Verkhratsky, Verkhratsky, Verkhratsky, Verkhratsky, Verret, Vitvitsky, Vlassenko, Vogelgesang, Volterra, Volterra, White, Wildsmith, Wilkin, Williams, Winkler, Wolf, Woltjer, Wright, Wu, Yagi, Yamashita, Yang, Ye, Yernool, Yuede, Zhang, Zhou, Zlomuzica, Zumkehr   +265 more
core   +2 more sources