Results 261 to 270 of about 183,502 (305)

Neurotrophic effects of antidepressant drugs

Current Opinion in Pharmacology, 2004
The past decade has witnessed a growing interest in the trophic effects of antidepressant drugs. Antidepressants stimulate the production and signaling of plasticity-related proteins such as neurotrophins and cAMP response element binding protein, and neurotrophin signaling appears to be both sufficient and necessary for antidepressant action in ...
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Phospholipids fromBombycis corpus and their neurotrophic effects

Archives of Pharmacal Research, 2003
Three phospholipids (4-6) and three aromatic amines (1-3) were obtained from the methanol extract of Bombycis corpus. Based on spectral data, their structures have been elucidated as nicotiamide (1), cytidine (2), adenine (3), 1-O-(9Z-octadecenoyl)-2-O-(8Z,11Z-octadecadienoyl) sn-glycero-3-phosphorylcholine (4), 1,2-di-O-hexadecanoyl-sn-glycero-3 ...
Hak Cheol, Kwon, I Yeon, Jung, Se Yeon, Cho, Ock Ryun, Cho, Min Cheol, Yang, Sung Ok, Lee, Jin Young, Hur, Sun Yeou, Kim, Jong Beom, Yang, Kang Ro, Lee   +9 more
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Opioids and neurotrophic effects

Current Opinion in Anaesthesiology, 1994
Exogenous or endogenous opioids act via opioid receptors to influence the expression of opioid genes, and may alter the short- or long-term expression of both opioid and non-opioid genes. Progress has been made towards understanding the cellular control mechanisms of opioid gene expression and this has in turn formed the basis for recent developments ...
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Neurotrophic effects of central nicotinic receptor activation

2000
A growing number of data have shown that compounds interacting with neuronal nicotinic acetylcholine receptors (nAChRs) have, both in vivo and in vitro, the potential to be neuroprotective and that treatment with nAChR agonists elicit long-lasting improvement of cognitive performance in a variety of behavioural tests in rats, monkeys and humans ...
N, Belluardo, G, Mudo, M, Blum, G, Amato, K, Fuxe   +4 more
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Neurotrophic effects on the vascular bed

Acta Medica Scandinavica, 1983
ABSTRACTAfter defining truly “neurotrophic” influences, and giving examples from the many studies of such influences on the somatomotor system, current research concerning sympathetic neurotrophic effects on the vascular bed is discussed. Tissue‐culture studies have made it clear that, particularly in early growth phases, local trophic influences are ...
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BMP2 shows neurotrophic effects including neuroprotection against neurodegeneration

NeuroReport, 2014
In this study, we found that BMP2 exerts neurotrophic effects, including a neuroprotective effect against nocodazole-induced neuritic degeneration, on neuronal cells. We also found that BMP2-induced neurotrophic effects are directly involved in Smad-dependent signaling as well as PI3K/PTEN-Akt-mTOR signaling. Moreover, BMP2-induced neurotrophic effects
Aybike, Saglam, Sukbum, Kim, Kwangwook, Ahn, Insuk, Oh, Kwan-Hee, Lee   +4 more
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Neurotrophic effect of Semaphorin 4D in PC12 cells

Biochemical and Biophysical Research Communications, 2003
Semaphorins provide crucial attractive and repulsive cues involved in axon guidance during neural development. Out of them, Semaphorin 4D (Sema4D) is enriched in the nervous and immune tissues, and acts as proliferative and survival factors of peripheral lymphocytes in the immune system, but is poorly understood in the nervous system.
Shiho, Fujioka, Kenta, Masuda, Marcia, Toguchi, Yoshiharu, Ohoka, Takayoshi, Sakai, Tatsuo, Furuyama, Shinobu, Inagaki   +6 more
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Neuroprotective and neurotrophic effects of Lanthionine Ketimine Ester

Neuroscience Letters, 2018
Lanthionine ketimine ethyl ester (LKE) is a synthetic derivative of the naturally occurring amino acid lanthionine ketimine. We previously showed that LKE reduced clinical signs in a mouse model of multiple sclerosis (MS) associated with reductions in axonal damage; however, whether LKE has direct beneficial actions on mammalian neuronal cells was not ...
Natalia, Marangoni, Kathy, Kowal, Zane, Deliu, Kenneth, Hensley, Douglas L, Feinstein   +4 more
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Neurotrophic effects of PACAP in the cerebellar cortex

Peptides, 2007
In the rodent cerebellum, PACAP is expressed by Purkinje neurons and PAC1 receptors are present on granule cells during both the development period and in adulthood. Treatment of granule neurons with PACAP inhibits proliferation, slows migration, promotes survival and induces differentiation.
Béatrice, Botia, Magali, Basille, Aurélie, Allais, Emilie, Raoult, Anthony, Falluel-Morel, Ludovic, Galas, Valérie, Jolivel, Olivier, Wurtz, Hitoshi, Komuro, Alain, Fournier, Hubert, Vaudry, Delphine, Burel, Bruno J, Gonzalez, David, Vaudry   +13 more
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A novel neurotrophic pyrimidine compound MS-818 enhances neurotrophic effects of basic fibroblast growth factor

Journal of Neuroscience Research, 1998
MS-818 (2-piperadino-6-methyl-5-oxo-5, 6-dihydro (7H) pyrrolo [2,3-d]pyrimidine maleate), a newly synthesized heterocyclic pyrimidine derivative, promotes neurite outgrowth in neuronal cell lines. The survival-promoting effect of MS-818 on cultured neurons isolated from mouse cortices was examined.
N, Sanjo, K, Owada, T, Kobayashi, H, Mizusawa, A, Awaya, M, Michikawa   +5 more
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