Results 71 to 80 of about 4,508,815 (293)

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Cerebral dopamine neurotrophic factor for spinal cord injury: Targeting JNK1 to relieve neuroinflammation and improve neural repair

Neural Regeneration Research
Previous studies have shown that endoplasmic reticulum stress induces neuronal apoptosis, necrosis, and pro-inflammatory microenvironment after spinal cord injury.
Yanxiao Xiang, Pengchao Du, Yayun Zhang, Hao Li, Songgang Wang, Xianlei Gao, Xin Pan, Hua Zhao   +7 more
doaj   +1 more source

Topical treatment with nerve growth factor for neurotrophic keratitis

, 2000
To evaluate the efficacy of nerve growth factor (NGF) in patients with neurotrophic ...
Bonini, S, Rama, P, Caprioglio, G, LAMBIASE, ALESSANDRO, Aloe, L., S Bonini   +5 more
core   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Brain-Derived Neurotrophic Factor in Chronic Periodontitis

Mediators of Inflammation, 2014
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family. Outside the nervous system, BDNF has been shown to be expressed in various nonneural tissues, such as periodontal ligament, dental pulp, and odontoblasts.
Jôice Dias Corrêa, Daniele Sirineu Pereira, Mila Fernandes Moreira Madeira, Celso Martins Queiroz-Junior, Danielle Glória Souza, Mauro Martins Teixeira, José Eustáquio Costa, Antônio Lúcio Teixeira, Tarcília Aparecida da Silva   +8 more
doaj   +1 more source

Modulation of Human Adipose Stem Cells’ Neurotrophic Capacity Using a Variety of Growth Factors for Neural Tissue Engineering Applications: Axonal Growth, Transcriptional, and Phosphoproteomic Analyses In Vitro

Cells, 2020
We report on a potential strategy involving the exogenous neurotrophic factors (NTF) for enhancing the neurotrophic capacity of human adipose stem cells (ASC) in vitro.
Katharina M. Prautsch, Alexander Schmidt, Viola Paradiso, Dirk J. Schaefer, Raphael Guzman, Daniel F. Kalbermatten, Srinivas Madduri   +6 more
doaj   +1 more source

Nerve growth factor and the neurotrophic factor hypothesis

, 1996
The discovery of nerve growth factor (NGF) over 40 years ago led to the formulation of the “Neurotrophic Factor Hypothesis”. This hypothesis states that developing neurons compete with each other for a limited supply of a neurotrophic factor (NTF ...
Mobley, William C, Li, Yiwen, Eric C. Yuen, Holtzman, David M, Yiwen Li, Charles L. Howe, David M. Holtzman, William C. Mobley, Howe, Charles L, Yuen, Eric C   +9 more
core   +1 more source

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source

Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells

, 1993
Ciliary neurotrophic factor was discovered based on its ability to support the survival of ciliary neurons, and is now known to act on a variety of neuronal and glial populations.
Joanne C. Conover, Mitchell P. Goldfarb, Nancy Y. Ip, Thomas M. DeChiara, Ip, Nancy Y., Yancopoulos, George D., Bates, Brian, Brian Bates, William T. Poueymirou, Goldfarb, Mitchell P., George D. Yancopoulos, Poueymirou, William T., Conover, Joanne C., DeChiara, Thomas M.   +13 more
core   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source