Results 91 to 100 of about 12,820,523 (360)

Therapeutic approaches with intravitreal injections in geographic atrophy secondary to age-related macular degeneration: current drugs and potential molecules [PDF]

, 2019
The present review focuses on recent clinical trials that analyze the efficacy of intravitreal therapeutic agents for the treatment of dry age-related macular degeneration (AMD), such as neuroprotective drugs, and complement inhibitors, also called ...
Cerini, Alberto, Greco A., La Cava M, Lambiase A, Limoli PG, Nebbioso M   +5 more
core   +1 more source

Treadmill Exercise Induced Functional Recovery after Peripheral Nerve Repair Is Associated with Increased Levels of Neurotrophic Factors

PLoS ONE, 2014
Benefits of exercise on nerve regeneration and functional recovery have been reported in both central and peripheral nervous system disease models. However, underlying molecular mechanisms of enhanced regeneration and improved functional outcomes are ...
Jae-sung Park, A. Höke
semanticscholar   +1 more source

An Innovative “Tooth‐On‐Chip” Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue

Advanced Healthcare Materials, EarlyView.
This work presents a “tooth‐on‐chip” device that mimics dental pulp tissue. By co‐culturing key cell types, it recreates vascular networks, stem cell niches, the odontoblast/dentine interface, and trigeminal innervation. This innovative platform provides a unique model of dental pulp structure and physiology, with significant potential for accelerating
Alessandro Cordiale, Deborah Stanco, Roberta Visone, Bernd Stadlinger, Pierfrancesco Pagella, Marco Rasponi, Thimios A. Mitsiadis   +6 more
wiley   +1 more source

Fumaric Acids Do Not Directly Influence Gene Expression of Neuroprotective Factors in Highly Purified Rodent Astrocytes

Brain Sciences, 2019
(1) Background: Dimethylfumarate (DMF) has been approved for the treatment of relapsing remitting multiple sclerosis. However, the mode of action of DMF and its assumed active primary metabolite monomethylfumarate (MMF) is still not fully understood ...
Kaweh Pars, Marina Gingele, Jessica Kronenberg, Chittappen K Prajeeth, Thomas Skripuletz, Refik Pul, Roland Jacobs, Viktoria Gudi, Martin Stangel   +8 more
doaj   +1 more source

Few‐Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell‐Like Phenotypes

Advanced Healthcare Materials, EarlyView.
Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar, Peifu Cheng, Tugce Dogruel, Maxsam Donta, Juhyung Jung, Naomi A. Asante, Donald S. Sakaguchi, Surya K. Mallapragada, Piran R. Kidambi, Metin Uz   +9 more
wiley   +1 more source

Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease

Neural Regeneration Research, 2014
Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson's disease.
S. Hegarty, G. O’Keeffe, A. Sullivan
semanticscholar   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

High-Intensity Interval Exercise Regulates Neurotrophic Factors and Astrocyte Activity in the Hippocampus and Cerebral Cortex [PDF]

운동과학
PURPOSE Exercise training is widely recognized as a complementary intervention that provides both therapeutic and preventive benefits for neurodegenerative diseases, given its strong association with brain health.
Junyoung Hong, Seon-Hee Kim, Jiyeon Kim, Chang Sun Kim, Dong-Ho Park, Hye Jung Kim, Sang Won Park, Jong-Won Kim, Young Hyun Jung, Seung Pil Yun   +9 more
doaj   +1 more source

Neurotrophic factors and hippocampal activity in PTSD. [PDF]

PLoS ONE, 2018
Although numerous studies have investigated the neurotrophic factors and hippocampal activity in posttraumatic stress disorder (PTSD) separately each other, it is unclear whether an association between neurotrophic factors and hippocampal activity is ...
Ümit Tural, Ahmet Tamer Aker, Emin Önder, Hatice Turan Sodan, Hatice Ünver, Gür Akansel   +5 more
doaj   +1 more source

The Role of Neurotrophic Factors Conjugated to Iron Oxide Nanoparticles in Peripheral Nerve Regeneration: In Vitro Studies

BioMed Research International, 2014
Local delivery of neurotrophic factors is a pillar of neural repair strategies in the peripheral nervous system. The main disadvantage of the free growth factors is their short half-life of few minutes.
O. Ziv-Polat, A. Shahar, Itay Levy, Hadas Skaat, S. Neuman, F. Fregnan, S. Geuna, C. Grothe, K. Haastert-Talini, S. Margel   +9 more
semanticscholar   +1 more source