Results 91 to 100 of about 189,919 (333)

Neurotrophic keratitis after micropulse transscleral diode laser cyclophotocoagulation. [PDF]

, 2019
PurposeTo report two cases of neurotrophic keratitis (NK) after micropulse transscleral cyclophotocoagulation (MP-TCP).ObservationsTwo patients with predisposing factors for decreased corneal sensation developed NK 1 month after MP-TCP. Both patients did
Han, Ying, Hsia, Yen C, Ou, Yvonne, Perez, Claudio I, Rose-Nussbaumer, Jennifer   +4 more
core   +1 more source

Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: Implication for neuroprotective therapies [PDF]

, 2013
Neuroprotective therapies based on brain-derived neurotrophic factor (BDNF) administration have been proposed for Huntington's disease (HD) treatment. However, our group has recently reported reduced levels of TrkB in HD mouse models and HD human brain ...
Alberch, J., Brito, V., Del Toro Ruiz, D., Gines, S., Giralt, A., Puigdellivol, M.   +5 more
core   +1 more source

Biomimetic Cell Membrane‐Coated Scaffolds for Enhanced Tissue Regeneration

Advanced Materials, EarlyView.
This review examines the development and use of cell membrane‐coated scaffolds in tissue engineering. Bioinspired phospholipid and glycocalyx coatings enhance anti‐fouling, anti‐thrombogenic, and selective molecular recognition properties. Native cell membrane coatings further support cell‐specific interactions, immune modulation, and reduced bacterial
Carmen Alvarez‐Lorenzo, Alejandro Ramirez‐Romero, Diana Peixoto, Maria Vivero‐Lopez, Isabel Rodríguez‐Moldes, Angel Concheiro   +5 more
wiley   +1 more source

Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 2: Where do we stand and where must we go next?

Neurobiology of Disease, 2017
The therapeutic potential of neurotrophic factors has been recognized for decades, with clinical trials in human neurodegenerative diseases extending back at least 25 years.
Raymond T. Bartus, Eugene M. Johnson, Jr.   +1 more
doaj   +1 more source

The GDNF-GFRα1 complex promotes the development of hippocampal dendritic arbors and spines via NCAM [PDF]

, 2016
The formation of synaptic connections during nervous system development requires the precise control of dendrite growth and synapse formation. Although glial cell line-derived neurotrophic factor (GDNF) and its receptor GFRα1 are expressed in the ...
Alsina, Fernando Cruz, Bonafina, Antonela, Fontanet, Paula, Irala, Dolores, Ledda, Maria Fernanda, Paratcha, Gustavo   +5 more
core   +2 more sources

Carbon Quantum Dots Assisted Virus Tracking: From Skin to Brain

Advanced Materials, EarlyView.
A novel carbon quantum dots‐dissolvable microneedle, CQDs‐dMN system, enables painless delivery and real‐time tracking of HSV‐1. The HSV‐1 is labeled with fluorescent CQDs and delivered to the skin dermis, minimizing damage compared to traditional methods.
Yaxiu Feng, Xiong Wang, Cien Chen, Di Wang, Changshun Hou, Yiran Wang, Huan Hu, Peiran Chen, LeiYing Qin, Qianya Wan, Xi Yao, Ming‐Liang He   +11 more
wiley   +1 more source

Neurotrophic growth factors for the treatment of amyotrophic lateral sclerosis: where do we stand ?

Frontiers in Neuroscience, 2010
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that results in progressive loss of motoneurons, motor weakness and death within 3-5 years after disease onset.
Alexandre Henriques, Alexandre Henriques, Alexandre Henriques, Claudia Pitzer, Armin Schneider   +4 more
doaj   +1 more source

Nanostructured Protein Surfaces Inspired by Spider Silk

Advanced Materials, EarlyView.
Harnessing recombinant spider silk technology, bioengineered spidroin variants enable the creation of functionalized nanostructured coatings with tunable affinity for specific targets, supporting a broad range of applications ‐ from antifouling surfaces and targeted drug delivery to advanced cell therapies and precision bio‐patterning via lithography ...
Martin Humenik, Thomas Scheibel
wiley   +1 more source

Astrocyte Interactions With Ti3C2Tx MXene Flakes: Insights Into Viability, Morphology, and Functionality

Advanced Materials Interfaces, EarlyView.
This study presents the first systematic evaluation of interactions between astrocytes and Ti3C2TX MXene flakes, a 2D nanomaterial with emerging neuroelectronic applications. Using a multimodal approach, including viability assays, morphometric analysis, and calcium imaging, this work demonstrates high biocompatibility and preserved function in ...
Dimitris Boufidis, Elizabeth N. Krizman, Cybelle M. Smith, Yihan Xie, Raghav Garg, John C. O'Donnell, Flavia Vitale, D. Kacy Cullen   +7 more
wiley   +1 more source

Vascular Endothelial Growth Factor (VEGF) Prevents the Downregulation of the Cholinergic Phenotype in Axotomized Motoneurons of the Adult Rat [PDF]

, 2018
Vascular endothelial growth factor (VEGF) was initially characterized by its activity on the vascular system. However, there is growing evidence indicating that VEGF also acts as a neuroprotective factor, and that its administration to neurons suffering ...
Acosta, Lourdes, Morcuende Fernández, Sara R., Pastor Loro, Ángel Manuel, Rodríguez de la Cruz, Rosa María, Silva Hucha, Silvia   +4 more
core   +1 more source