Results 131 to 140 of about 186,825 (346)
Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo. [PDF]
Theo Hagg, Silvio Varon
openalex +1 more source
Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang+13 more
wiley +1 more source
Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen+13 more
wiley +1 more source
The therapeutic potential of neurotrophic factors has been recognized for decades, with clinical trials in human neurodegenerative diseases extending back at least 25 years.
Raymond T. Bartus+1 more
doaj
Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-βInduced Neuronal Death [PDF]
Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving an interaction of the phosphatase
Fernández, Ana M.+5 more
core
A wireless‐charging sustained oxygen release from conductive microgels (SOCO) served as an antenna and an on‐demand O2 release for nerve regeneration is developed. Introducing “electromagnetic messenger”, using external alternating magnetic field (AMF) to enhance catalytic oxygen release and electrical stimulation to promote the reconstruction of blood
Hoi Man Iao+15 more
wiley +1 more source
Characterization of a glial cell line persistently infected with borna disease virus (BDV): influence of neurotrophic factors on BDV protein and RNA expression [PDF]
Kathryn M. Carbone+3 more
openalex +1 more source
Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?
Despite advancements in implantable electrode technology, challenges persist in scaling up these devices to record most of the neuronal activity across the cortex. This review explores the limitations of both rigid and flexible probes, including tissue damage and foreign body response, while also discussing emerging biohybrid strategies.
Attila Kaszás+5 more
wiley +1 more source
Single‐Molecule Protein Profiling Using Nanopores and Dimeric Aptamer‐Modified DNA Carriers
We developed a nanopore‐based biosensor for single‐molecule protein profiling using aptamer‐modified DNA carrier dimerization strategy, enabling selective and ultrasensitive detection of proteins and protein complexes. This approach promises advances in early‐stage clinical diagnostics and precision medicine.
Xiaoyi Wang+4 more
wiley +2 more sources
This study identifies akermanite among six bioceramics and reveals its ability to enhance Schwann cell's proliferation, migration, and secretion. When combined with silk sericin, the composite conduit synergistically enhances Schwann cell‐mediated regenerative processes.
Qiangfei Su+10 more
wiley +1 more source