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The Pharmacology of Neurotrophic Factors [PDF]
, 1995 Since the early discoveries of Rita Levi-Montalcini and coworkers [1] the field of neurotrophic factors has expanded dramatically, and has become a pharmacological subject. We are facing a great number of neurotrophic factors (NTFs) with defined biological actions and conceptual therapeutic potential.
Hans Thoenen, A. Claudio Cuello
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Sortilins in Neurotrophic Factor Signaling
2014The sortilin family of Vps10p-domain receptors includes sortilin, SorLA, and SorCS1-3. These type-I transmembrane receptors predominate in distinct neuronal tissues, but expression is also present in certain specialized non-neuronal cell populations including hepatocytes and cells of the immune system.
Glerup, S +2 more
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Neurotrophic factors in regeneration
Current Opinion in Neurobiology, 1991Nerve growth factor, fibroblast growth factor, and ciliary neurotrophic factor can protect selected populations of neurons from some of the degenerative changes that otherwise follow axonal injury or other insults. The function of diffusible neurotrophic factors in axonal regeneration is still unclear, however.
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Neurotrophic Factors in the Auditory Periphery
Annals of the New York Academy of Sciences, 1999ABSTRACT:Many of the neurotrophic factors promote the survival of developing peripheral sensory neurons, and they might be useful as therapeutic agents in the adult neuronal systems. During development, neurotrophin‐3 (NT‐3) and brain‐derived neurotrophic factor (BDNF) mRNAs are expressed in the auditory sensory epithelium, which composes the ...
Ulla Pirvola +3 more
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2008
The nervous system growth factors, or neurotrophic factors, comprise several families of proteins that influence neuronal survival, neuritic outgrowth, and cell function from embryonic development through old age. Given their extensive influences on neurons, neurotrophic factors represent candidate mechanisms for treating neurodegenerative and axonal ...
Eugene M. Johnson, Mark H. Tuszynski
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The nervous system growth factors, or neurotrophic factors, comprise several families of proteins that influence neuronal survival, neuritic outgrowth, and cell function from embryonic development through old age. Given their extensive influences on neurons, neurotrophic factors represent candidate mechanisms for treating neurodegenerative and axonal ...
Eugene M. Johnson, Mark H. Tuszynski
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Role of neurotrophic factors in depression
Current Opinion in Pharmacology, 2007Major depression is associated with reduced volumes in the hippocampus and prefrontal cortex, whereas antidepressant treatments promote several forms of neuronal plasticity, including neurogenesis, synaptogenesis and neuronal maturation, in the hippocampus. Several neurotrophic factors are associated with depression or antidepressant action.
Vootele Voikar +2 more
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Neurotrophic Factors in Neuromuscular Disease
Physical Medicine and Rehabilitation Clinics of North America, 2005Neurotrophic factors (NTFs) are small dimeric proteins essential for development, function, maintenance, and plasticity of the vertebrate nervous system [1]. NTFs include glial-derived neurotrophic factor (GDNF), insulin-like growth factor 1 and 2 (IGF-1/2), ciliary neurotrophic factor (CNTF), vascular endothelial growth factor (VEGF) and the ...
Michael D. Weiss, B. Jane Distad
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Neurotrophic Factors: An Overview
2017The neurotrophins are a family of closely related proteins that were first identified as survival factors for sympathetic and sensory neurons and have since been shown to control a number of aspects of survival, development, and function of neurons in both the central and peripheral nervous systems.
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Ciliary neurotrophic factor as an injury factor
Current Opinion in Neurobiology, 1993This article reviews recent evidence suggesting that endogenous ciliary neurotrophic factor may be involved in neural responses to injury, and discusses the possibility that ciliary neurotrophic factor could have therapeutic applications in a clinical setting.
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Other neurotrophic factors: Glial cell line‐derived neurotrophic factor (GDNF)
Microscopy Research and Technique, 1999Glial cell line-derived neurotrophic factor (GDNF) was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is a more potent survival factor for dopaminergic neurons and the noradrenergic neurons of the locus coeruleus than other ...
Hannu Sariola, Mart Saarma
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