Results 161 to 170 of about 115,306 (252)

Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications

Neuroprotection, EarlyView.
Circadian dysregulation contributes to Alzheimer's disease through sleep disruption, clock‐gene dysfunction, neuroinflammation, impaired proteostasis, and metabolic imbalance. These alterations promote cognitive decline and disease progression, while circadian biomarkers and chronotherapeutic interventions offer opportunities for precision diagnosis ...
Bivek Singh, Filippo Pigazzani, Roberto Manfredini   +2 more
wiley   +1 more source

Reduced serum neurotrophic factors and monoamine neurotransmitters in epilepsy patients with comorbid depression. [PDF]

Front Neurol
Sun S, Han Y, Liu X, Yang L, Han T, Lin Y, Feng Y.   +6 more
europepmc   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Influence of Lactation Stage on Content of Neurotrophic Factors, Leptin, and Insulin in Human Milk. [PDF]

Molecules
Sinkiewicz-Darol E, Łubiech K, Adamczyk I.   +2 more
europepmc   +1 more source

Relationship between klotho, neurotrophic factors (BDNF, NGF, GDNF) and cognitive functions in patients with bipolar disorder. [PDF]

BMC Psychiatry
Çelebi Z, Yazıcı E, Güzel Erdoğan D, Davutoglu O, Yazıcı AB.   +4 more
europepmc   +1 more source

Effects of transcranial direct current stimulation on pain and function in patients with knee osteoarthritis: A systematic review and meta‐analysis

PM&R, EarlyView.
Abstract Objective The aim of this systematic review and meta‐analysis is to determine the effects of transcranial direct current stimulation (TDCS) on pain (considering the different types of pain measured) and function in adults with knee osteoarthritis (OA).
Noemí Moreno‐Segura, Sara Mollà‐Casanova, Elena Muñoz‐Gómez, Marta Inglés, Pilar Serra‐Añó   +4 more
wiley   +1 more source

Effect of exercise on brain-derived neurotrophic factors in middle-aged and older adults with type 2 diabetes mellitus: a systematic review and meta-analysis. [PDF]

Front Physiol
Li Z, Cui Z, Wang T, Zheng H, Li K, Yang C.   +5 more
europepmc   +1 more source

Stem cell–mediated neuroplasticity and psychological recovery in cancer survivors: Mechanisms, evidence, and translational challenges

Precision Medical Sciences, EarlyView.
Cancer therapies can trigger neuroinflammation and disrupted neuroplasticity, contributing to cognitive impairment and psychological distress in survivors. Stem cells (NSCs/MSCs) and their extracellular vesicles may restore neural niches via trophic support, immunomodulation, synaptic remodeling, and vascular repair, but require rigorous safety, dosing,
Xinyi Yang
wiley   +1 more source

IFN-β therapy rescues dysregulated IFN-stimulated proteins, serum cytokines, and neurotrophic factors in multiple sclerosis: Multiplex analysis of short-term and long-term IFN responses. [PDF]

PLoS One
Li L, Olcer M, Wang Z, Song Y, Ke J, Feng X, Reder AT.   +6 more
europepmc   +1 more source

Stem Cell‐Based Approaches for Neurotrophic Keratopathy: From Ocular Surface to Neuro‐Ophthalmology

Sensory Neuroscience, EarlyView.
ABSTRACT Neurotrophic keratopathy is an uncommon, but potentially sight‐threatening, corneal disorder that results from impaired trigeminal sensory innervation. The loss of corneal sensation disrupts epithelial stability, weakens wound healing, and may lead to persistent epithelial defects, stromal ulceration, and, in the most advanced cases, corneal ...
Matteo Capobianco, Marco Zeppieri
wiley   +1 more source