Results 171 to 180 of about 186,825 (346)

Physics of Protein Aggregation in Normal and Accelerated Brain Aging

BioEssays, EarlyView.
Soluble monomeric proteins precipitate via nucleation into insoluble amyloids in response to age‐related exposures (e.g., microbes, nanoparticles). Persistent soluble‐to‐insoluble phase transition depletes the functional proteins. In normal aging, replacement matches loss; in accelerated aging, it does not.
Alberto J. Espay, Andrea Sturchio, Alberto Imarisio, Emily J. Hill, Brady Williamson, Kora Montemagno, Christian Hoffmann, Hugo Le Roy, Dragomir Milovanovic, Fredric P. Manfredsson   +9 more
wiley   +1 more source

Neurotrophic Factors in Experimental Cerebral Acanthamoebiasis. [PDF]

Int J Mol Sci, 2022
Łanocha-Arendarczyk N, Kot K, Baranowska-Bosiacka I, Kapczuk P, Łanocha A, Kosik-Bogacka DI.   +5 more
europepmc   +1 more source

Purification and Characterization of Neurotrophic Factor for Retinal Cholinergic Neurons Derived from Cultured Hippocampal Neurons.

, 1994
Tohru Yasukura, Kyoko Omori, Toshiko Mikami, Masafumi Inoue, M Uyama, Chiyoko Inagaki   +5 more
openalex   +1 more source

Memory Gate Controlled by Contexts: Potential Key Structure That Could Link Small Associative Failures With Severe Cognitive Disorders

BioEssays, EarlyView.
Memory gate (MG) hypothesis assumes a neural structure that connects inputs to appropriate contexts. Panel A shows an input (green) that, in the MG, does not match the context (red): memory does not recognize it. Panel B shows that, in the MG, the context (green) matches the input: memory recognizes the pattern.
Eduardo Mizraji, Juan Lin, Andrés Pomi
wiley   +1 more source

Effects of concurrent training and CoQ10 on neurotrophic factors and physical function in people with Multiple Sclerosis: a pilot study. [PDF]

Eur J Transl Myol, 2023
Hossein Haghighi A, Ahmadi A, Carotenuto A, Askari R, Nikkhah K, Bagherzadeh-Rahmani B, Sharabadi H, Souza D, Gentil P.   +8 more
europepmc   +1 more source

Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.

, 1991
Beat Knüsel, John Winslow, Arnon Rosenthal, Louis E. Burton, Derice P. Seid, Károly Nikolics, Franz Hefti   +6 more
openalex   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Neurotrophic Factors as Regenerative Therapy for Neurodegenerative Diseases: Current Status, Challenges and Future Perspectives. [PDF]

Int J Mol Sci, 2023
El Ouaamari Y, Van den Bos J, Willekens B, Cools N, Wens I.   +4 more
europepmc   +1 more source

Glial cell line-derived neurotrophic factor (GDNF) improves spatial learning in aged Fischer 344 rats [PDF]

, 1999
Mary Ann Pelleymounter, Mary Jane Cullen, Mary Baker, Denis Healy   +3 more
openalex   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source