Results 221 to 230 of about 12,648,804 (372)

Nobiletin Ameliorates Aβ1–42‐Induced Cognitive Disorder and Mitochondrial Dysfunction via Targeting the Key Circadian Regulator Bmal1

open access: yesFood Safety and Health, EarlyView.
Nobiletin (NOB) ameliorates Aβ‐induced Alzheimer’s pathology by restoring circadian rhythm via Bmal1. NOB rescues cognitive deficits, synaptic damage, and mitochondrial dysfunction in mice and neurons by enhancing Bmal1/Clock oscillations and downstream mitochondrial integrity, positioning circadian regulation as a therapeutic target for Alzheimer's ...
Huajing Gao   +9 more
wiley   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

open access: yesIbrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

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