Results 1 to 10 of about 1,885 (233)
Neurotrophin-3 Antibodies Disrupt the Normal Development of the Chick Retina [PDF]
The Journal of Neuroscience, 1996 When chick embryos are treated with a monoclonal antibody specifically blocking the activity of neurotrophin-3 (NT-3), the development of the retina is profoundly affected. Fewer axons are found in the optic nerve, and the retina shows abnormalities in all layers.
Paola Bovolenta +5 more
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High abundances of neurotrophin 3 in atopic dermatitis mast cell [PDF]
Journal of Occupational Medicine and Toxicology, 2009 Neurotrophin 3 (NT-3) is a member of the neurotrophin family, a group of related proteins that are known to regulate neuro-immune interactions in allergic diseases. Their cellular sources and role in the recruitment of mast cell precursors in atopic dermatitis have not been characterized in detail so far.Characterize NT-3 on a transcriptional and ...
Tanja C Fischer +4 more
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Neurotrophin‐3 and FLT3 Tyrosine Kinase Receptor in Perinatal Life [PDF]
Mediators of Inflammation, 2005 Our aim is to determine—in 30 healthy full‐term infants and their mothers—circulating levels of neurotrophin‐3 (NT‐3) (important for antenatal and postnatal brain development and implicated in the immune response) and FLT3 tyrosine kinase receptor (FLT3) (controlling hematopoiesis and found in the nervous tissue), in the fetal and neonatal life.
Konstantinos E. Nikolaou +4 more
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Neurotrophin‐3 receptors in the developing chicken retina [PDF]
European Journal of Biochemistry, 1993 Neurotrophin 3 (NT‐3) had specific high‐affinity receptors (HNT‐3R) in the developing chick retina at all ages between embryonic day (E) 4 and E14. The affinity of HNT‐3R for 125I‐NT‐3 did not change with the developmental state. A dissociation constant (kd) of 13 pM was obtained.
Rodríguez-Tebar, Alfredo +2 more
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Frontiers in Endocrinology, 2021 Neurotrophin-3 (NT3), through activation of its tropomyosin-related kinase receptor C (TrkC), modulates neuronal survival and neural stem cell differentiation.
María Bové +26 more
doaj +1 more source
Production and characterization of recombinant mouse neurotrophin‐3 [PDF]
European Journal of Biochemistry, 1992 Neurotrophin‐3 (NT‐3) is a neurotrophic factor that has recently been cloned on the basis of its structural similarity to other members of the nerve growth factor (NGF) gene family. In order to produce this protein, a recombinant vaccinia virus containing the coding region for mouse NT‐3 was constructed. Conditioned medium harvested from cells infected
Gotz, R. +3 more
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Frontiers in Cellular Neuroscience, 2021 Sensorineural hearing loss is irreversible and is associated with the loss of spiral ganglion neurons (SGNs) and sensory hair cells within the inner ear. Improving spiral ganglion neuron (SGN) survival, neurite outgrowth, and synaptogenesis could lead to
Judith S. Kempfle +10 more
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Crystallization and preliminary structural studies of neurotrophin‐3 [PDF]
Protein Science, 1994 AbstractNeurotrophin‐3 (NT‐3) has been crystallized in 2 forms. Orthorhombic crystals, space group P21212, diffracted to 2.8 Å and have cell dimensions a = 39.1 Å, b = 54.0 Å, and c = 65.5 Å. The second form is space group P43212, with cell dimensions a = b = 67.1 Å, and c = 107.9 Å. The tetragonal crystals diffract to 2.8 Å at room temperature and 2.5
Jennifer A. Kelly +3 more
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Introduction of a Neurotrophin-3 Transgene into Muscle Selectively Rescues Proprioceptive Neurons in Mice Lacking Endogenous Neurotrophin-3 [PDF]
Neuron, 1997 To clarify the role of muscle-derived neurotrophin-3 (NT-3) in the development of sensory neurons, we generated transgenic mice selectively overexpressing NT-3 in skeletal muscles under the control of a myogenin promoter (myo-NT-3 mice). The myo-NT-3 transgene was then bred into an NT-3 null mutant (-/-) line to generate myo-NT-3, NT-3(-/-) mice in ...
Lijuan Zhou +3 more
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Frontiers in Aging Neuroscience, 2022 Sevoflurane anesthesia induces cognitive impairment, which may lead to perioperative neurocognitive disorders (PND). However, the factors and molecular mechanism underlying this impairment remains unclear.
Lichi Xu +13 more
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