Results 91 to 100 of about 1,885 (233)

Conversion Surgery After Administration of a TRK Inhibitor for Unresectable Parotid Gland Secretory Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background The NTRK fusion gene is detected in most salivary gland secretory carcinomas. While tropomyosin receptor kinase (TRK) inhibitors are used for various solid tumors with the fusion gene, there are no reports regarding TRK inhibitor use for unresectable parotid gland carcinomas that subsequently shrink and become resectable.
Arisa Nagano, Takuma Matoba, Daisuke Kawakita, Kiyoshi Minohara, Sho Iwaki, Hiroshi Tsuge, Koji Tsukamoto, Sekai Kikuchi, Satsuki Nakano, Takayuki Murase, Yuichiro Tada, Shinichi Iwasaki   +11 more
wiley   +1 more source

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source

Developing Schwann Cells Acquire the Ability to Survive without Axons by Establishing an Autocrine Circuit Involving Insulin-Like Growth Factor, Neurotrophin-3, and Platelet-Derived Growth Factor-BB [PDF]

, 1999
Carola Meier, Eric Parmantier, Angela Brennan, Rhona Mirsky, Kristján R. Jessen   +4 more
openalex   +1 more source

Altered Brain Expression of Insulin and Insulin-Like Growth Factors in Frontotemporal Lobar Degeneration: Another Degenerative Disease Linked to Dysregulation of Insulin Metabolic Pathways

ASN Neuro, 2019
Background Frontotemporal lobar degeneration (FTLD) is the third most common dementing neurodegenerative disease with nearly 80% having no known etiology. Objective Growing evidence that neurodegeneration can be linked to dysregulated metabolism prompted
Connie J. Liou, Ming Tong, Jean P. Vonsattel, Suzanne M. de la Monte   +3 more
doaj   +1 more source

Epigenetic regulation in cognitive impairment: Focus on N6‐methyladenosine modification and its potential role in perioperative neurocognitive disorders

Ibrain, EarlyView.
N6‐methyladenosine (m6A), a key mammalian mRNA modification, affects cognition via gene regulation. This review explores its role in cognition and perioperative neurocognitive disorders (PNDs). Animal studies link m6A dysregulation to PND‐related mechanisms, but direct evidence is preliminary.
Ting Liu, Xiao‐Juan Yang, Lin Zhou, Mi Gan, Ting‐Ting He, Sen Hong, Yan‐Yan Feng, Gao Su, You‐Xiao Zhao, Ying Cao, Qing‐Fan Zeng   +10 more
wiley   +1 more source

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

Medicine Bulletin, EarlyView.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao, Mengdi Guo, Kehan Chen, Mei‐Ling Jiang, Lin‐ming Zhang, Lorenzo Di Cesare Mannelli, Cun‐jin Zhang   +6 more
wiley   +1 more source

Absence of Sensory Neurons before Target Innervation in Brain-Derived Neurotrophic Factor-, Neurotrophin 3-, and TrkC-Deficient Embryonic Mice [PDF]

, 1997
Daniel J. Liebl, Lino Tessarollo, Mary Ellen Palko, Luis F. Parada   +3 more
openalex   +1 more source

Intratumoral Nerve Phased Development: A Promising Therapeutic Target

Medicine Bulletin, EarlyView.
ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che, Hang Wang, Han Wang, Yi‐Zhou Jiang   +3 more
wiley   +1 more source

Allogeneic Bone Marrow‐Derived Mesenchymal Stem Cells for Parkinson's Disease: A Randomized Trial

Movement Disorders, EarlyView.
Abstract Background Neuroinflammation contributes to Parkinson's disease (PD) progression and motor dysfunction. Allogeneic human mesenchymal stem cells (allo‐hMSCs) may reduce neuroinflammation and improve motor symptoms. Objectives To evaluate the efficacy of repeated intravenous doses of 10 × 106/kg allo‐hMSCs in improving motor symptoms in patients
Mya C. Schiess, Jessika Suescun, Juan D. Martinez‐Lemus, Charles Green, Tia S. Thomas, Mohammad Shahnawaz, Emily Tharp, Nikunj B. Satani, Jerome G. Saltarrelli, Christopher Adams, Marie‐Francoise Doursout, Vanessa Thyne, Rula Abuamouneh, Elsa M. Rodarte, Sean I. Savitz, Timothy M. Ellmore   +15 more
wiley   +1 more source

Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development [PDF]

, 1996
Michael J. Donovan, Rebecca T. Hahn, Lino Tessarollo, Barbara L. Hempstead   +3 more
openalex   +1 more source