Results 111 to 120 of about 16,647,982 (293)

Chinese herbal formula Tongluo Jiunao injection protects against cerebral ischemia by activating neurotrophin 3/tropomyosin-related kinase C pathway

open access: yesNeural Regeneration Research, 2015
The Chinese herbal formula Tongluo Jiunao, containing the active components Panax notoginseng and Gardenia jasminoides, has recently been patented and is in use clinically.
Peiman Alesheikh   +7 more
doaj   +1 more source

Interleukin-1 beta and neurotrophin-3 synergistically promote neurite growth in vitro

open access: yesJournal of Neuroinflammation, 2011
Pro-inflammatory cytokines such as interleukin-1 beta (IL-1β) are considered to exert detrimental effects during brain trauma and in neurodegenerative disorders.
F. Boato   +6 more
semanticscholar   +1 more source

Chronic Stress Induces Neurotrophin-3 in Rat Submandibular Gland

open access: yesYonsei Medical Journal, 2012
Plasma neurotrophin-3 (NT-3) levels are associated with several neural disorders. We previously reported that neurotrophins were released from salivary glands following acute immobilization stress. While the salivary glands were the source of plasma neurotrophins in that situation, the association between the expression of neurotrophins and the ...
Saruta, Juri   +7 more
openaire   +2 more sources

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

Neurotrophic Control of Puberty: From Molecular Signaling to Disorders of Pubertal Timing

open access: yesCurrent Issues in Molecular Biology
The onset of puberty is a critical developmental milestone regulated by complex neuroendocrine networks that integrate genetic, metabolic, and environmental cues.
Roberto Paparella   +13 more
doaj   +1 more source

Functional Role of Neurotrophin-3 in Synapse Regeneration by Spiral Ganglion Neurons on Inner Hair Cells after Excitotoxic Trauma In Vitro

open access: yesJournal of Neuroscience, 2011
Spiral ganglion neurons (SGNs) are postsynaptic to hair cells and project to the brainstem. The inner hair cell (IHC) to SGN synapse is susceptible to glutamate excitotoxicity and to acoustic trauma, with potentially adverse consequences to long-term SGN
Qiong Wang, S. Green
semanticscholar   +1 more source

Target-derived neurotrophic factors regulate the death of developing forebrain neurons after a change in their trophic requirements [PDF]

open access: yes, 2001
Many neurons die as the normal brain develops. How this is regulated and whether the mechanism involves neurotrophic molecules from target cells are unknown.
Asavaritikrai, P   +3 more
core   +1 more source

p75NTR Promotes Circadian‐Driven Mineralization During Tooth Development via CK2/PER2 Pathway

open access: yesCell Proliferation, EarlyView.
The diagram illustrates how the circadian rhythm regulates the p75NTR‐CK2‐PER2 axis, driving rhythmic biomineralisation during tooth development. ABSTRACT Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles.
Manzhu Zhao   +8 more
wiley   +1 more source

Protein synthesis at synaptic sites on dendrites [PDF]

open access: yes, 2001
Studies over the past 20 years have revealed that gene expression in neurons is carried out by a distributed network of translational machinery. One component of this network is localized in dendrites, where polyribosomes and associated membranous ...
Schuman, Erin M., Steward, Oswald
core   +1 more source

Diabetic kidney disease, biomarkers, and finerenone

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley   +1 more source

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