Results 141 to 150 of about 16,647,982 (293)

The TrkC-PTPσ complex governs synapse maturation and anxiogenic avoidance via synaptic protein phosphorylation

open access: yesThe EMBO Journal
The precise organization of pre- and postsynaptic terminals is crucial for normal synaptic function in the brain. In addition to its canonical role as a neurotrophin-3 receptor tyrosine kinase, postsynaptic TrkC promotes excitatory synapse organization ...
Husam Khaled   +14 more
doaj   +1 more source

Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration [PDF]

open access: yes, 2014
Introduction : The degenerate intervertebral disc (IVD) becomes innervated by sensory nerve fibres, and vascularised by blood vessels. This study aimed to identify neurotrophins, neuropeptides and angiogenic factors within native IVD tissue and to ...
Binch, Abbie L.A.   +6 more
core   +2 more sources

Contribution of Sympathetic Sensory Coupling to Craniofacial Nociception

open access: yesOrthodontics &Craniofacial Research, EarlyView.
ABSTRACT Stress and anxiety are associated with increased pain intensity in temporomandibular disorders (TMDs) patients. It is possible that this association is due to a direct interaction between the sympathetic and sensory nervous systems. This narrative review examines evidence for a potential sympathetic sensory interaction in deep craniofacial ...
Brian Edwin Cairns
wiley   +1 more source

Differential Regulation of the Expression of Nerve Growth Factor, Brain-Derived Neurotrophic Factor, and Neurotrophin-3 after Excitotoxicity in a Rat Model of Huntington's Disease

open access: yesNeurobiology of Disease, 1998
In the present study we have evaluated changes in nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin 3 (NT-3) mRNA expression induced by different glutamate receptor agonists injected into the neostriatum. Up-regulation of NGF
Josep M. Canals   +6 more
doaj   +1 more source

Sensory and Sympathetic Nerve Localization in Mouse Temporomandibular Joint and Knee Joint Neuro‐Musculoskeletal Tissues

open access: yesOrthodontics &Craniofacial Research, EarlyView.
ABSTRACT Objective Sympathetic‐sensory coupling is increasingly implicated in joint homeostasis and disease. Towards the long‐term goal of deciphering its role in temporomandibular disorders (TMDs), we characterised the spatial relationships of sympathetic and sensory nerves and their receptors in the mouse temporomandibular joint (TMJ) and trigeminal ...
Qianlin Ye   +4 more
wiley   +1 more source

Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells

open access: yesFrontiers in Immunology, 2017
Plasmacytoid dendritic cells (pDCs) regulate innate and adaptive immunity. Neurotrophins and their receptors control the function of neuronal tissue. In addition, they have been demonstrated to be part of the immune response but little is known about the
Joanna Bandoła   +19 more
doaj   +1 more source

Neurotrophin‐3 regulates mast cell functions in neonatal mouse skin

open access: yesExperimental Dermatology, 2004
Abstract:  Nerve growth factor (NGF) has long been recognized as an important mast cell (MC) growth factor. To explore whether other neurotrophins (NTs) of the NGF family, which are widely expressed in mouse skin, affect the numbers and/or functions of MCs we examined the effects of NT‐3 on neonatal skin MCs. We demonstrate that TrkC, the high affinity
Martin, Metz   +7 more
openaire   +4 more sources

Nitrate Prevents Sjögren's Disease by Modulating T Helper Cells via NF‐κB Pathway Suppression

open access: yesOral Diseases, EarlyView.
ABSTRACT Objective Sjögren's disease (SjD) is a chronic autoimmune disease characterized by abnormal T helper (Th) cell distribution in the salivary glands (SGs). Although nitrate can regulate immune responses and preserve SGs function, its preventive effects on SjD remain unexplored.
Conglin Du   +8 more
wiley   +1 more source

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