Results 171 to 180 of about 16,647,982 (293)

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

Combined brain-derived neurotrophic factor and neurotrophin-3 treatment is preferred over either one separately in the preservation of the auditory nerve in deafened guinea pigs. [PDF]

Front Mol Neurosci, 2022
Vink HA, Ramekers D, Thomeer HGXM, Versnel H.   +3 more
europepmc   +1 more source

A New Role for Neurotrophin-3 [PDF]

The American Journal of Pathology, 1998
Vladimir A. Botchkarev, Pia Welker, Kathryn M. Albers, Natalia V. Botchkareva, Martin Metz, Gary R. Lewin, Silvia Bulfone-Paus, Eva M.J. Peters, Gerd Lindner, Ralf Paus   +9 more
openaire   +1 more source

Growth Standards for Children With Smith–Magenis Syndrome (SMS)

American Journal of Medical Genetics Part A, Volume 200, Issue 3, Page 569-578, March 2026.
ABSTRACT Smith–Magenis syndrome (SMS, OMIM 182290) is a complex syndromic diagnosis marked by neurobehavioral differences and distinct facial dysmorphisms, caused by haploinsufficiency of the retinoic acid‐1 (RAI1) gene either by a pathogenic sequence variant or deletion at chromosome 17p11.2 involving a portion or all of this gene.
Julie Hoover‐Fong, John McGready, Leah Fleming, Kerry Schulze, Folami Duncan, Alexis Leonard, Marie Christine de Blois Boucard, Danilo Moretti‐Ferreira, Andrea L. Gropman, Wendy J. Introne, Ann C. M. Smith   +10 more
wiley   +1 more source

Neurotrophin-3 gene polymorphism in schizophrenia and its relation with diseases severity and cognitive dysfunction.

J Neurosci Rural Pract, 2023
Keshri N, Nandeesha H, Rajappa M, Menon V.   +3 more
europepmc   +1 more source

Is the 10‐Year Trajectory of Physical Activity Associated With the Incidence of Mild Cognitive Impairment in Older Adults?

Psychogeriatrics, Volume 26, Issue 2, March 2026.
ABSTRACT Objective To identify leisure‐time physical activity trajectories in older adults and examine their association with the incidence of mild cognitive impairment (MCI) over a decade. Methods This longitudinal study used data from the EpiFloripa Aging Cohort Study (2009–2019). The sample included older adults of both sexes, aged 60 years or older,
Joel de Almeida Siqueira Junior, Francisco Timbó de Paiva Neto, Carla Elane Silva Santos, Lucas Gomes Alves, Eleonora d'Orsi, Cassiano Ricardo Rech   +5 more
wiley   +1 more source

Risperidone Reduces Matrix Metalloproteinase-9 and Increases Neurotrophin-3 in Schizophrenia Spectrum of Disorder. [PDF]

Indian J Clin Biochem, 2022
Chenniappan R, Nandeesha H, Kattimani S, Goud AC, Thiagarajan D.   +4 more
europepmc   +1 more source

Human Dorsal Root Ganglia Neuronal Cell Line to Study Nociceptive Signaling: A New Pipeline for Pain Therapy

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
The nociceptive properties of differentiated human HD10.6 cells were characterized by multiple approaches (A). Peripheral sensitization was induced within HD10.6 cells in response to an inflammatory cocktail (B), modeling nociceptors in a chronic pain state.
Sara A. Dochnal, Yixing Du, Daniella Bandari, Kaue Franco Malange, Jack Bryant, Julia Borges Paes Lemes, Abby Whitford, Anna R. Cliffe, Prashant Mali, Kim Dore, Yury I. Miller, Tony L. Yaksh   +11 more
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, Volume 16, Issue 2, Page 252-267, February 2026.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Highlights of the FEBS3+ meeting Exploring molecular frontiers

FEBS Open Bio, Volume 16, Issue 2, Page 240-242, February 2026.
FEBS+ meeting Exploring molecular frontiers, held in Pula, Croatia, in autumn 2024 was jointly organized by the Croatian, Finnish, and Swedish Member Societies of the Federation of European Biochemical Societies (FEBS). The congress covered a wide variety of different biochemical themes, some of the highlights of which are presented in this ‘In the ...
Morana Dulić, Hannu Koistinen, Ronnie Berntsson   +2 more
wiley   +1 more source