Results 181 to 190 of about 1,885 (233)

Activity and Heterogeneity of Astrocytes in Neurological Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 6, Issue 9, September 2025.
Astrocytes display heterogeneity in various neurological disorders and behavioral neuropsychiatric disorders. Astrocytes influence the progression of neurological diseases through neuroinflammation, oxidative stress, metabolic abnormalities, intercellular interactions, and a spectrum of other pathophysiological processes.
Shijie Mao, Rui Qiao, Qi Wang, Ling Shen, Daxing Li, Xinchen Huo, Jindou Wang, Kunxuan Liu, Wenjing Chen, Tianhao Zhu, Beicheng Zhang, Shuo Leng, Ying Bai   +12 more
wiley   +1 more source

Neurotrophin 3 in the esophageal smooth-to-skeletal muscle transdifferentiation and muscarinic-to-nicotinic acetylcholine receptor transition

, 2006
Heather E. Angka, Boris Kablar
openalex   +1 more source

Epithelial–Mesenchymal Transition in Cancer: Insights Into Therapeutic Targets and Clinical Implications

MedComm, Volume 6, Issue 9, September 2025.
This graphical abstract summarizes the effects of ionizing radiation (IR) on epithelial–mesenchymal transition (EMT), emphasizing critical processes such as DNA damage repair, tumor microenvironment interactions, and resistance mechanisms. It highlights EMT‐induced radioresistance regulators, such as TGF‐β, Wnt, Notch, ERK, and various miRNAs, as well ...
Dhasarathdev Srinivasan, Ranjith Balakrishnan, Ankush Chauhan, Jeevan Kumar, Dinesh Murugan Girija, Reena Shrestha, Rupendra Shrestha, Rajasekaran Subbarayan   +7 more
wiley   +1 more source

and Analysis of Neurotrophin‐3 Activation of Arf6 and Rac‐1

, 2008
Pedro F. Esteban, Paola Caprari, Hye‐Young Yoon, Paul A. Randazzo, Lino Tessarollo   +4 more
openalex   +2 more sources

Impact of Confounding Factors in Human Postmortem Brain Tissues on Gene Expression Profiles: A Comparison of Patients With Schizophrenia, Bipolar Disorder, and Nonpsychiatric Controls

Neuropsychopharmacology Reports, Volume 45, Issue 3, September 2025.
This study examined the impact of confounding factors on gene expression in postmortem brain tissue from individuals with psychiatric disorders. The expression was significantly associated with factors such as pH, RIN, PMI, and storage duration, highlighting the importance of accounting for these variables when interpreting transcriptomic data ...
Masataka Hatano, Atsuko Nagaoka, Kazusa Miyahara, Yuto Hosogai, Risa Shishido, Hideomi Hamasaki, Mizuki Hino, Akiyoshi Kakita, Hiroaki Tomita, Yasuto Kunii, Itaru Miura   +10 more
wiley   +1 more source

Conductive Nerve Conduits With Orientated Topological Structures From Ice‐Templating Technology

Smart Medicine, Volume 4, Issue 3, September 2025.
Conductive nerve conduits featuring oriented topological structures are engineered through ice‐templating technology, utilizing hydrogels and temperature gradients. Such conduits enhance peripheral nerve regeneration by integrating conductivity, aligned architecture, and growth factors, as demonstrated by improved motor recovery in rat models with ...
Hui Zhang, Kaichen Wang, Dongyu Xu, Shuangshuang Miao, Yanhong Dai, Panmiao Liu, Huan Wang   +6 more
wiley   +1 more source

Selective Effects of Acutely Administered N‐Acetyl‐Cysteine in Rodent Models of Nicotine‐Conditioned Behaviours

Addiction Biology, Volume 30, Issue 9, September 2025.
ABSTRACT Chronic nicotine administration leads to neuroadaptations, an important process in nicotine and tobacco dependence for which treatments are limited. The cysteine pro‐drug, N‐acetyl‐cysteine (NAC), is a promising glutamatergic agent that has shown some clinical efficacy in reducing nicotine use in humans.
Kelsey Stoddart, Michael Davies, Jamie Oughton, Emma Malcolm, Shakir D. AlSharari, Mohammed Shoaib   +5 more
wiley   +1 more source

Reorganization of Mitochondrial Function and Architecture in Response to Plant‐Derived Alkaloids: Anatabine, Anabasine, and Nicotine, Investigated in SH‐SY5Y Cells and in a Cellular Model of Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 31, Issue 9, September 2025.
The effects of tobacco alkaloids: anatabine, anabasine, and nicotine, were investigated in a model of mitochondrial stress, mimicking cellular pathology accompanying Parkinson's disease development. The alkaloids modulated mitochondrial function and alleviated the hallmarks of mitochondrial stress. However, they acted via slightly different mechanisms.
Dominika Malińska, Karolina Drabik, Bernadeta Michalska, Jarosław Walczak, Małgorzata Partyka, Monika Prill, Jędrzej Szymański, Paulina Patalas‐Krawczyk, Karolina Piecyk, Jerzy Duszyński, Mariusz R. Więckowski, Joanna Szczepanowska   +11 more
wiley   +1 more source

Involvement of Spinal Neurotrophin-3 in Electroacupuncture Analgesia and Inhibition of Spinal Glial Activation in Rat Model of Monoarthritis

, 2011
Wen‐Li Mi, Qi‐Liang Mao‐Ying, Xiaowei Wang, Xiu Li, Chang-Jiang Yang, Jianwei Jiang, Jin Yu, Jun Wang, Qiong Liu, Yanqing Wang, Gen-Cheng Wu   +10 more
openalex   +1 more source

The Microbiota‐Gut‐Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders

CNS Neuroscience &Therapeutics, Volume 31, Issue 9, September 2025.
The microbiota‐gut‐brain axis (MGBA) is a crucial regulator of neurological and neuropsychiatric disorders, with gut microbiota dysbiosis linked to various diseases. Gut microbiota changes can lead to neurodegenerative diseases like depression, autism, schizophrenia, Parkinson's, Alzheimer's, dementia, multiple sclerosis, epilepsy, anxiety, and autism ...
Md. Faysal, Mehrukh Zehravi, Baishakhi Sutradhar, Md Al Amin, Thukani Sathanantham Shanmugarajan, Uppuluri Varuna Naga Venkata Arjun, Susithra Ethiraj, Akiladevi Durairaj, Girija Dayalan, Shaik Khadeer Ahamad, Safia Obaidur Rab, Kannan Raman, Talha Bin Emran   +12 more
wiley   +1 more source