A radiolabeled drug tracing method to study neurotrophin-3 retention and distribution in the cochlea after nano-based local delivery [PDF]
MethodsX, 2020 Hearing loss is the most common sensory deficit worldwide with no approved therapeutics for treatment. Local neurotrophin delivery into the cochlea has shown great potential in protecting and repairing the sensory cells important for hearing.
Patrick Lam +7 more
doaj +2 more sources
Degenerative Lumbosacral Spinal Stenosis Alters Neurotrophin-3 and -4 Expression: Impact of Metabolic and Behavioral Factors [PDF]
Current Issues in Molecular BiologyDegenerative lumbosacral spinal stenosis (DLSS) is a progressive condition characterized by narrowing of the spinal canal and subsequent neural compression, often leading to chronic pain and disability.
Małgorzata Sobańska +4 more
doaj +2 more sources
Clinical Medicine Insights: Pathology, 2009 Neurotrophic factors are a group of proteins that act as paracrine and autocrine growth factors. They are involved in the regulation of morphogenesis and development of several tissues.
Alessandra Casciaro +5 more
doaj +2 more sources
Neurotrophin-3 and FLT3 Tyrosine Kinase Receptor in Perinatal Life [PDF]
Mediators of Inflammation, 2005 Our aim is to determine—in 30 healthy full-term infants and their mothers—circulating levels of neurotrophin-3 (NT-3) (important for antenatal and postnatal brain development and implicated in the immune response) and FLT3 tyrosine kinase receptor (FLT3)
Ariadne Malamitsi-Puchner +4 more
doaj +4 more sources
Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates. [PDF]
Biol Psychiatry, 2019 An early-life anxious temperament (AT) is a risk factor for the development of anxiety, depression, and comorbid substance abuse. We validated a nonhuman primate model of early-life AT and identified the dorsal amygdala as a core component of AT's neural circuit. Here, we combine RNA sequencing, viral-vector gene manipulation, functional brain imaging,
Fox AS +16 more
europepmc +6 more sources
Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. [PDF]
, 2020 One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an injury has constituted a difficult clinical challenge.
Anderson, Aileen J +8 more
core +1 more source
Frontiers in Endocrinology, 2021 Neurotrophin-3 (NT3), through activation of its tropomyosin-related kinase receptor C (TrkC), modulates neuronal survival and neural stem cell differentiation.
María Bové +26 more
doaj +1 more source
Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary Report
Balkan Medical Journal, 2015 Background: Allergic rhinitis is a common inflammatory nasal mucosal disease characterized by sneezing, watery nasal discharge, nasal obstruction and itching.
Onur İsmi +6 more
doaj +1 more source
Endogenous neurotrophin-3 promotes neuronal sprouting from dorsal root ganglia
Neural Regeneration Research, 2015 In the present study, we investigated the role of endogenous neurotrophin-3 in nerve terminal sprouting 2 months after spinal cord dorsal root rhizotomy.
Xu-yang Wang +8 more
doaj +1 more source
Drosophila Neurotrophins Reveal a Common Mechanism for Nervous System Formation [PDF]
, 2008 Neurotrophic interactions occur in Drosophila, but to date, no neurotrophic factor had been found. Neurotrophins are the main vertebrate secreted signalling molecules that link nervous system structure and function: they regulate neuronal survival ...
Aberle +136 more
core +4 more sources