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Schizophrenia and neurotrophin‐3 alleles
Acta Psychiatrica Scandinavica, 1997Studies of brain anatomy and premorbid functioning indicate that schizophrenia may be of neurodevelopmental origin. In the neurotrophic factor neurotrophin‐3 (NT‐3) gene, the A3/147‐bp allele in a dinucleotide repeat polymorphism located in the promoter region was found to be associated with schizophrenia in a Japanese study. Another NT‐3 polymorphism (
A. Tylec+6 more
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Neurotrophin-3 Improves Functional Constipation
American Journal of Gastroenterology, 2003Neurotrophin-3 (NT-3) is a neurotrophic factor involved in the growth, development, and function of the nervous system. In preliminary studies, s.c. recombinant methionyl-human NT-3 enhanced transit throughout the GI tract and increased stool frequency in normal and constipated subjects.
James M. Gordon+11 more
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NEUROTROPHIN‐3 EXPRESSION IN HUMAN PANCREATIC CANCERS
The Journal of Pathology, 1997Some neurotrophic factors stimulate process outgrowth in peripheral and/or central nerve fibres. There is no published report that has focused on the expression of neurotrophic factors in human pancreatic cancer except basic fibroblast growth factor.
H Kitagawa+11 more
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Neurotrophin‐3 gene polymorphism associated with schizophrenia
Acta Psychiatrica Scandinavica, 1994The recent possible neurodevelopmental etiology of schizophrenia makes the neurotrophin‐3 (NT‐3) gene an interesting candidate locus. We studied the allelic distributions of dinucleotide repeat polymorphism at the NT‐3 gene locus in 70 patients with schizophrenia and in 70 controls. A highly significant difference between the two groups was observed at
Rimmei Fukuda+8 more
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A crucial role for neurotrophin-3 in oligodendrocyte development
Nature, 1994The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 promote the survival of subpopulations of vertebrate neurons in vitro, but so far only nerve growth factor has been demonstrated to be essential for normal neuronal development; no neurotrophin has previously been shown to function in normal ...
Barres, B. A.+5 more
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Neurotrophin–3 is required for proper cerebellar development
Nature Neuroscience, 1999Neurotrophin–3 (NT–3) is a member of the neurotrophin family, which includes nerve growth factor (NGF), brain–derived neurotrophic factor (BDNF) and neurotrophin–4/5 (NT–4/5). These factors are crucial for development of the peripheral nervous system1, but not the central nervous system (CNS), except that NT–3 and BDNF have been implicated in the ...
Brian Bates+6 more
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Neurotrophin 3 is increased in the spontaneously hypertensive rat
Journal of Hypertension, 2001To determine whether the noradrenergic sympathetic hyperinnervation in the spontaneously hypertensive rat (SHR), a genetic model of essential hypertension, is associated with changes in neurotrophin 3 (NT3) concentrations.NT3 levels were measured using a sensitive enzyme-linked immunosorbent assay (ELISA) in the superior cervical ganglia (SCG), heart ...
Robert A. Rush, Shu Hua Zhang
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Sensory ganglia require neurotrophin-3 early in development [PDF]
ABSTRACT The role played by neurotrophin-3 during the development of quail sensory ganglia was investigated using a mono-clonal antibody that specifically blocks the biological activity of this neurotrophin. Neutralisation of neu-rotrophin-3 was initiated during completion of gangliogen-esis.
Gaese, F., Kolbeck, R., Barde, Y. A.
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